Skip to comments.GlyNAC improves multiple defects in aging to boost strength and cognition in older humans (Some defects “reversed to the levels found in young adults” - eGFR up 15%, IL-6 down 77%, TNFa down 40%, Fasting Insulin down 55%, etc.)
Posted on 05/17/2022 7:53:57 PM PDT by ConservativeMind
A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione—could improve many age-associated defects in older humans.
The results of this study show that older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. The benefits declined after stopping supplementation for 12 weeks. GlyNAC supplementation was well tolerated during the study period.
Animal studies conducted in the Sekhar lab have shown that restoring glutathione levels by providing GlyNAC reverses glutathione deficiency, reduces oxidative stress and fully restores mitochondrial function in aged mice.
"We worked with eight older adults 70 to 80 years of age, comparing them with gender-matched younger adults between 21 and 30 years old," Sekhar said. "We measured glutathione in red-blood cells, mitochondrial fuel-oxidation, plasma biomarkers of oxidative stress and oxidant damage, inflammation, endothelial function, glucose and insulin, gait-speed, muscle strength, exercise capacity, cognitive tests, gene-damage, glucose-production and muscle-protein breakdown rates and body composition. Before taking GlyNAC, all these measurements were abnormal in older adults when compared with those in younger people."
The older participants took GlyNAC for 24 weeks, and then stopped it for 12 weeks.
"We are very excited by the results," Sekhar said. "After taking GlyNAC for 24 weeks, all these defects in older adults improved and some reversed to the levels found in young adults." The researchers also determined that older adults tolerated GlyNAC well for 24 weeks. The benefits, however, declined after stopping GlyNAC supplementation for 12 weeks.
(Excerpt) Read more at medicalxpress.com ...
This is available as a supplement from Nestle (over a $1 a day), which bought the rights to the patent, but you can make this from 600 mg of glycine (capsule or powder) and 600 mg of N-Acetyl Cysteine (NAC), taken together, without other supplements, each day. The cost to make it yourself can be as low as 12 cents a day.
This is a really amazing elixir, made from two conditional amino acids we apparently can’t make enough of as we age. It also wasn’t known these amino acids did so much to make mitochondria work, or work again, if the cells had entered senescence.
Everyone should be considering this supplement.
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
Thanks for all of the health pings.
Is that supplement even available?
“Everyone should be considering this supplement.”
I’m waiting on whatever makes Biden sound like a competent person. Granted, he never was, so a supplement that turns back the clock will only get us a younger idiot in his case.
You can make it having a 600 mg NAC capsule and a 1/4 teaspoon of glycine powder or a 600 mg capsule of glycine.
Why should they be taken without other supplements? Absorption issues? And how long should the time interval be, regarding other supplements?
Does anyone have any thoughts about just using glutathione?
We get these two amino acids, but instead of NAC, it’s l-cysteine, from meat and other foods. For some reason, getting it from those sources makes it unavailable to benefit us the same way, or everyone would stay young from just eating meat and dairy, in my humble opinion.
Try it all together if you want. The participants had their GlyNAC dose at prescribed times, by itself, to my understanding, as part of the study, but it might work, otherwise.
I’d give it at least a half hour. That’s what I do.
Thank you, Jane.
I have been taking this combination for a long time along with other supplements. Unfortunately, it doesn’t do anything for my bad left hip as well as my left knee. But I guess you just can’t win them all.
It’s more expensive and it appears to not get everywhere it’s needed, from prior things I’ve read.
I consider this a valuable post. Thank you.
it’s just glycine, an amino acid, plus n-acetylcysteine, which can be bought inexpensively from swansonvitamins ...
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