Posted on 05/11/2022 9:15:57 AM PDT by Red Badger
While immortality might forever be out of reach, a long, healthy retirement is the stuff dreams are made of.
To that end, a recent study suggests that the kinds of memory problems common in old age can be reversed, and all it takes is some cerebrospinal fluid harvested from the young. In mice, at least.
If this is sounding a little familiar, you might be thinking of a similar series of studies done back in the mid-2010s, which found that older mice could be generally 'rejuvenated' with the blood of younger animals – both from humans and from mice. The FDA even had to warn people to stop doing it.
This new study instead examined the links between memory and cerebrospinal fluid fluid (CSF), and the results show considerable promise, even providing a mechanism for how it works, and highlighting a potential growth factor that could mimic the results.
"We know that CSF composition changes with age, and, in fact, these changes are used routinely in the clinic to assess brain health and disease biomarkers," Stanford University neurologist Tal Iram told ScienceAlert.
"However, we don't know well how these changes affect the function of the cells in the aging brain."
To investigate, the researchers, led by Iram, took older mice (between 18–22 months old) and gave them light shocks on the foot, at the same time as a tone and flashing light were activated. The mice were then split into groups, and either given young mouse CSF (from animals 10 weeks old) or artificial CSF.
In experiments like this, if the mice 'freeze' when they see the tone and light, it means they're remembering the foot shock, and are preparing for it to happen again.
In this study, three weeks after the foot shocks were conducted (which the team called "memory acquisition"), the researchers tested the mice, finding that the animals that had been given the CSF from young mice showed higher-than-average freezing rates, suggesting they had better memory.
This was followed up by a battery of other experiments to test the theory, which revealed that certain genes (that are different in young-versus-old CSF) could be used to get the same response. In other words, without needing to extract someone's brain fluid.
"When we took a deeper look into gene changes that occurred in the hippocampus (a region associated with memory and aging-related cognitive decline), we found, to our surprise, a strong signature of genes that belong to oligodendrocytes," Iram told ScienceAlert.
"Oligodendrocytes are unique because their progenitors are still present in vast numbers in the aged brain, but they are very slow in responding to cues that promote their differentiation. We found that when they are re-exposed to young CSF, they proliferate and produce more myelin in the hippocampus."
In the mice, an infusion of a fibroblast growth factor called FGF17 was able to boost oligodendrocyte progenitor cells in a similar way to the CSF injection.
Oligodendrocytes are particularly helpful because they produce myelin, a material that covers and insulates neuron fibers. The infusion of FGF17 was itself able to help the older mice increase memory ability.
A diagram showing the results in the cell. (Nature)
While this field of research has a very very long way to go before we can use such insights to increase memory in older humans, the findings are exciting, and hopefully future studies following these leads can help us live out our retirement without having to resort to the body fluids of young whippersnappers.
"Iram and colleagues have broken ground in the field of brain health and aging by discovering that young CSF contains a factor that aids memory recall in older mice," write researchers Miriam Zawadzki & Maria K. Lehtinen from Boston Children's Hospital in an accompanying News and Views piece.
"Not only does the study imply that FGF17 has potential as a therapeutic target, but it also suggests that routes of drug administration that allow therapeutics to directly access the CSF could be beneficial in treating dementia. Any such treatments will be hugely helpful in supporting our aging population."
The research has been published in Nature.
Where will Soros and Hillary get baby brain fluid?
Q never said anything like that.
The QAnon internet speculators may have. They’re just a mixed bag of internet conspiracy people coming up with anything
new gov law- all older folks must receive brain fluid from younger liberals in far left universities-
Senate voting on:
Selective sex abortions
Abortion on demand. No limits.
Taxpayers and Health Insurance must fund.
Bug Jack Barron.😳
Ukraine is the Fetal stem cell TREATMENT center of the entire world. Where do Fetal stem cells come from? https://stemcell-ukraine.com/
how very transylvanian. a “fountain of youth.”
they sure seem hot to penetrate the brain/blood barrier. now that their mrna jab has failed horribly, are they looking for new justification?
https://www.physiciansforlife.org/stem-cells-abortion-baby-parts-a-the-ukraine/
Article from 2007, read and get some insight into the abortion industry.
Thinking the same thing. Soros, Nazi Pelosi, Klaus, etc. have been doing this at level 2.0 for a while now.
excerpt from article
He found that all Ukrainian women are advised to abort because preborn children are excellent sources of organs and stem cells.
Dr. Lazaryev found that the abortion rate in Ukraine is much, much higher than the official figures would suggest — in fact, about 1.2 million annually in a nation with a population of about 46 million, or more than six times higher than the abortion rate in the United States.
As Dr. Lazaryev says, “The only thing which protects unborn life in Ukraine is the courage of pregnant women.”
Continuing his investigations, Dr. Lazaryev found that women were paid $200 to $300 — three month’s salary — to carry their pregnancies to a very late stage and to deliver the babies alive in a kind of forced premature birth. This procedure allows the living baby’s organs to be harvested while they are still as fresh as possible.
Dr. Lazaryev also found that every region of Ukraine has twin institutions. One does the late-term ‘artificial deliveries,’ and the other dismembers the live-born baby and passes the parts on to other buyers, who screen the material and then sell it at a huge markup to the worldwide network of “clinics” like the Institute for Regenerative Medicine.
Abortion clinics located in the poorest parts of Donetsk and Kharkov sell aborted babies to middlemen, who ship the sad little bodies to cities like Moscow, where there are more than 50 beauty parlors using fetal injections.
I believe all babies and little children will go with us in the rapture, and I think the rapture is coming very soon.
Agree with both 100%.
In the first “Left Behind” book it was interesting in the beginning that one of the ladies on the plane was pregnant. A couple seconds later she wasn’t.
Thank you for exposing it to the light.
No, but they do a lot of hair sniffing.
Agree
Does it work on old democRATS like Crime Boss Joey Ice Cream?
ADRENOCHROME baby!!
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.