Posted on 04/13/2022 5:45:28 AM PDT by Red Badger
Edible, fluorescent tags can suss out fake medications.
Recent developments such as the explosion of online pharmacies and supply chain issues have made it easier for counterfeiters to profit from fake or adulterated medications. Now, researchers reporting in ACS Central Science have created edible tags with fluorescent silk proteins, which could be placed directly on pills or in a liquid medicine. The codes within the tags can be read by a smartphone app to verify the source and quality of these pharmaceuticals.
Online pharmacies have taken off in recent years, delivering many types of medications directly to consumers’ homes. Some of these businesses are legitimate, but others operate illegally, supplying counterfeit drugs that are substandard, incorrectly labeled, or laced with unwanted components. In addition, global supply chain problems have made it easy for fake medications to infiltrate the market. To instill trust in consumers, pharma companies label the outside packaging of their products with bar codes, QR codes, holograms, and radio frequency identifiers, allowing distributors and retailers to manage products throughout the supply chain. Yet there aren’t equivalent codes for consumers to verify the source of individual pills or liquid doses inside a container.
Researchers have developed fluorescent synthetic materials, such as microfibers and nanoparticles, as tracking codes, but the substances are potentially unsafe to consume. So, Seong-Wan Kim, Young Kim and colleagues wanted to see whether silk, which is an edible and “generally recognized as safe” material, could be placed directly onto medications and made to fluoresce, helping consumers make sure their purchases are what they claim to be.
Edible Fluorescent Silk Tags Can Suss Out Fake Medications
Silkworms can produce edible, fluorescent silk cocoons (left side of left image); the proteins from the cocoons can be used in codes (right) to verify the authenticity of medications. Credit: Adapted from ACS Central Science 2022, DOI: 10.1021/acscentsci.1c01233
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The researchers genetically modified silkworms to produce silk fibroins — edible proteins that gives silk fibers their strength — with either a cyan, green or red fluorescent protein attached. They dissolved the fluorescent silk cocoons to create fluorescent polymer solutions, which they applied onto a thin, 9-mm-wide film of white silk in a seven-by-seven grid. Shining blue violet, blue, and green light onto the grid revealed the 3D cyan, green and red square patterns, respectively.
Using optical filters over the phone’s camera, an app the team designed can scan the fluorescent pattern, decoding the digitized key using a deep learning algorithm and opening up a webpage, which could host information about the drug’s source and authenticity. And because some liquid medications are alcohol-based, the researchers placed a coded silk film in a clear bottle of Scotch whisky, and found that the fluorescent code was still readable with the app.
Finally, the researchers showed that the fluorescent silk proteins are broken down by gastrointestinal enzymes, suggesting that the silk codes are not only edible but also can be digested by the body. The researchers say that placing these edible code appliqués onto pills or in liquid doses could empower patients and their care providers to avoid the unintentional consumption of fake treatments.
Reference: “Edible Matrix Code with Photogenic Silk Proteins” 13 April 2022, ACS Central Science.
DOI: 10.1021/acscentsci.1c01233
The authors acknowledge funding from the Cooperative Research Program for Agriculture Science & Technology Development from Rural Development Administration of the Republic of Korea, the U.S. Air Force Office of Scientific Research and the Trask Innovation Fund from Purdue University.
Counterfeiters could create edible tags with fluorescent silk proteins, which could be placed directly on pills or in a liquid medicine.
Anything to protect big pharma’s profits.
Even so-called legitimate pharmaceuticals may have counterfeit or otherwise illegitimate and hazardous content, such as mercury, fetal cells and/or graphene-oxide.
As long as my statin meds continue to be laced with opioids...I ain’t complaining. My arteries may be clogging up...but I feel GREAT!
About 10 years ago my sister was on a heart med. Had started on the brand name but had to switch to generic. AFter the switch she said it felt like it wasn’t working. Talked to the pharmacist who assured her it was the same.
A bit later it came out that the generic supplied to several pharmacies was a fake.
I had the same thing happen with BP meds from India.
They were just crap ........................
Yeah, just because the pharmacist says it’s not fake, doesn’t mean anything!
This app would be great. Got to be expensive and suspect, also.
Where can one get this ‘app’?? What is it called?? Anyone??
https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c01233
I don’t think it has been released yet................
Thanks for the link
Get the ones with embedded RFID tags.
Rumor has it that they’ve been tested on certain vaccines already.
Luciferase in injections?
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