Posted on 03/28/2022 2:32:21 PM PDT by nickcarraway
A Johns Hopkins Children’s Center-led study in mice and lab-grown cells finds sulforaphane could help prevent and treat illnesses caused by certain coronaviruses, including COVID-19.
Researchers at Johns Hopkins Children’s Center report evidence from lab experiments that a chemical derived from a compound found abundantly in broccoli and other cruciferous plants may offer a potentially new and potent weapon against the viruses that cause COVID-19 and the common cold. COVID-19 has already killed more than 6 million people worldwide, and studies have shown that common colds cost an estimated economic loss of $25 billion in the U.S. alone each year.
In a study described on March 18, 2022, in the Nature journal Communications Biology, the scientists showed that sulforaphane, a plant-derived chemical, known as a phytochemical, already found to have anti-cancer effects, can inhibit the replication of SARS-CoV-2, the coronavirus that causes COVID-19, and another human coronavirus in cells and mice.
While the results are promising, the researchers caution the public against rushing to buy sulforaphane supplements available online and in stores, noting that studies of sulforaphane in humans are necessary before the chemical is proven effective, and emphasizing the lack of regulation covering such supplements.
Sulforaphane’s natural precursor is particularly abundant in broccoli, cabbage, kale, and Brussels sprouts. First identified as a “chemopreventive” compound by a team of Johns Hopkins scientists decades ago, natural sulforaphane is derived from common food sources, such as broccoli seeds, sprouts, and mature plants, as well as infusions of sprouts or seeds for drinking. Previous studies, including those at Johns Hopkins Medicine, have shown sulforaphane to have cancer and infection-prevention properties by way of interfering with certain cellular processes.
“When the COVID-19 pandemic started, our multidisciplinary research teams switched our investigations of other viruses and bacteria to focus on a potential treatment for what was then a challenging new virus for us,” says Children’s Center microbiologist Lori Jones-Brando, Ph.D., an assistant professor of pediatrics at the Johns Hopkins University School of Medicine and the senior author of the paper. “I was screening multiple compounds for anti-coronavirus activity and decided to try sulforaphane since it has shown modest activity against other microbial agents that we study.” The researchers used purified, synthetic sulforaphane purchased from commercial chemical suppliers in their experiments.
In one experiment, the research team first exposed cells to sulforaphane for one to two hours before infecting the cells with SARS-CoV-2 and the common cold coronavirus, HCoV-OC43. They found that low micromolar (µM) concentrations of sulforaphane (2.4–31 µM) reduced the replication by 50% of six strains of SARS-CoV-2, including the delta and omicron variants, as well as that of the HCoV-OC43 coronavirus. The investigators also observed similar results with cells that had been previously infected with the viruses, in which the protective effects of sulforaphane were seen even with an already established virus infection.
The group also examined the effects of sulforaphane when combined with remdesivir, an antiviral medication used to shorten the recovery of hospitalized adults with COVID-19 infections. In their findings, remdesivir inhibited 50% of the replication of HCoV-OC43 and SARS-CoV-2 at 22 µM and 4 µM, respectively. Further, the research team reports that sulforaphane and remdesivir interacted synergistically at several combination ratios to reduce by 50% the viral burden in cells infected with HCoV-OC43 or SARS-CoV-2. In this context, synergism means that lower doses of both sulforaphane (for example, 1.6–3.2 µM) and remdesivir (for example, 0.5–3.2 µM), when combined, are more effective against the viruses than either applied alone.
“Historically, we have learned that the combination of multiple compounds in a treatment regimen is an ideal strategy to treat viral infections,” says Alvaro Ordonez, M.D., the first author of the paper and an assistant professor of pediatrics at the Johns Hopkins University School of Medicine. “The fact that sulforaphane and remdesivir work better combined than alone is very encouraging.”
The researchers then conducted studies in a mouse model of SARS-CoV-2 infection. They found that giving 30 milligrams of sulforaphane per kilogram of body weight to mice before infecting them with the virus significantly decreased the loss of body weight that’s typically associated with virus infection (7.5% decrease). Further, the pretreatment resulted in a statistically significant decrease in both the viral load, or amount of virus, in the lungs (17% decrease) and upper respiratory tract (9% decrease) as well as the amount of lung injury (29% decrease) compared with infected mice that were not given sulforaphane. The compound also decreased inflammation in the lungs, protecting the cells from a hyperactive immune response that seems to be one of the driving factors that has caused many people to die from COVID-19.
“What we found is that sulforaphane is antiviral against HCoV-OC43 and SARS-CoV-2 coronaviruses while also helping control the immune response,” Ordonez says. “This multifunctional activity makes it an interesting compound to use against these viral infections, as well as those caused by other human coronaviruses.”
The team plans to conduct studies in humans to evaluate if sulforaphane can be effective in preventing or treating these infections.
“Despite the introduction of vaccines and other medications that can have side effects, effective antiviral agents are still necessary to prevent and treat COVID-19, particularly considering the potential effects of new coronavirus variants arising in the population,” Jones-Brando says. “Sulforaphane could be a promising treatment that is less expensive, safe, and readily available commercially.”
Reference: “Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice” by Alvaro A. Ordonez, C. Korin Bullen, Andres F. Villabona-Rueda, Elizabeth A. Thompson, Mitchell L. Turner, Vanessa F. Merino, Yu Yan, John Kim, Stephanie L. Davis, Oliver Komm, Jonathan D. Powell, Franco R. D’Alessio, Robert H. Yolken, Sanjay K. Jain and Lorraine Jones-Brando, 18 March 2022, Communications Biology. DOI: 10.1038/s42003-022-03189-z
Along with Jones-Brando and Ordonez, other Johns Hopkins Medicine authors of the paper include C. Korin Bullen, Andres F. Villabona-Rueda, Elizabeth A. Thompson, Mitchell L. Turner, Vanessa F. Merino, Yu Yan, John Kim, Stephanie L. Davis, Oliver Komm, Jonathan D. Powell, Franco R. D’Alessio, Robert H. Yolken and Sanjay K. Jain.
The study was funded by the National Institutes of Health, Mercatus Center, the Center for Infection and Inflammation Imaging Research at the Johns Hopkins University School of Medicine and the Stanley Medical Research Institute.
Jones-Brando, Ordonez, Yolken and Jain are co-inventors on a pending patent application (USPA 22 719 #63/142,598), “Methods for inhibiting coronaviruses using sulforaphane” filed by The Johns Hopkins University. All other authors have no competing interests
It’s not so bad in a capsule.
Eating plenty of broccoli helps with the social-distancing thing.
I’m gonna die then.
It apparently has sulforaphane in it.
My question is why doesn't everyone think broccoli tastes and smells like rotten garbage, or do people actually like the taste and smell of rotten garbage?
George HW Bush didn’t like broccoli, and now he’s dead. Coincidence?
Covid has shown that the Modern western allopathic model of medicine has not only lost the fine art of hands on root cause diagnosis but also is corrupt beyond our wildest imagination at every level and no longer serves best interest of your health and well-being. Naturopathic physicians have been promoting sulforaphane for at least a year now. We need to legalize and license naturopathic practitioners in every state. There’s simply no good reason not to, and every good reason to do so. AMA will, of course, object.
I don’t like rotten garbage, but I love broccoli.
I like Broccoli, especially the dude that directed the Bond films.
The new female Broccoli not so much.
Why do they always find these things in Broccoli, cauliflower, brussel sprouts, etc.? Yuck!
Supertasters like you and me perceive it that way. Genetic.
“ She’s choppin’ broccoli!”
Beat me to it
I’m fine with broccoli, but I would rather die of covid than eat Brussels sprouts.
I love broccoli, but it does smell awful while cooking. (Yes, I get the joke re: my screen name....) Usually with these “discoveries” you have to eat an 18 wheeler load a day to get the effect. I’ll take the supplement if it’s available and affordable. (By which I mean if it isn’t immediately banned. Gotta keep the sheep vulnerable to the next phase of The Reset!)
“George HW Bush didn’t like broccoli, and now he’s dead. Coincidence?”
LOL!!
Oohh…roasted halved Brussels Sprouts with balsamic glaze, crispy outside, piping hot. Yum!
I’d rather eat another Cruciferous Vegetable, Brussels Sprouts, with lots of butter, salt & pepper.
My favorite veggie! OK, potatoes are first and corn is 2nd. My favorite green vegetable. Love broccoli. Yum.
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