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There's a Reason 90% of Drugs Fail Clinical Trials, And We Can Fix It
https://www.sciencealert.com ^ | February 24, 2022 | DUXIN SUN

Posted on 02/25/2022 5:47:24 AM PST by Red Badger

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1 posted on 02/25/2022 5:47:24 AM PST by Red Badger
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To: Red Badger

This is a similar issue to cybersecurity in new product development. We’ve been working for years to inject a security mindset into the development process from the beginning, but too often we still see new products, esp. on the web, that are full of holes in order to speed to market. I’m glad to see the problem isn’t unique to IT.


2 posted on 02/25/2022 5:51:09 AM PST by rarestia (“A nation which can prefer disgrace to danger is prepared for a master, and deserves one.” -Hamilton)
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To: Red Badger

I’m not taking anything made after 2000.
I’m going to turn into a hippie and use plants…


3 posted on 02/25/2022 5:52:15 AM PST by EEGator
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To: rarestia

When you get it all secure, let us know, and we’ll un-corrupt the government. ;)


4 posted on 02/25/2022 5:54:02 AM PST by Empire_of_Liberty
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To: Red Badger

The idea of nasal Covid vaccines comes to mind that would break the infection cycle.


5 posted on 02/25/2022 5:55:18 AM PST by Brian Griffin
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To: Empire_of_Liberty

Try as I might for the last 10 years, few developers actually listen. They’re under tight deadlines to get things out into their pipelines, and security is often a stumbling block for them. Sad, really, and a big reason why I’ll likely be employed until I’m on death’s door.


6 posted on 02/25/2022 6:03:14 AM PST by rarestia (“A nation which can prefer disgrace to danger is prepared for a master, and deserves one.” -Hamilton)
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To: Red Badger

“side effects are too strong”

That has been my observation with so many modern drugs. Unless the med is supposed to cure a critical medical condition or save a life, the problems caused by side effects can outweigh it’s benefits.


7 posted on 02/25/2022 6:06:54 AM PST by antidemoncrat (somRead more at: https://economicti Astronomers see white dwarf 'switch on and off' for first time)
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To: Red Badger

Or you could develop a completely new drug and call it a miracle “vaccine” with practically no testing and absolutely no idea what the long term effects will be.

And then pay off or marginalize anyone who points out that your miracle vaccine not only doesn’t work, but many thousands of people will be permanently injured or even killed by it.


8 posted on 02/25/2022 6:11:43 AM PST by Blood of Tyrants (Inside every liberal is a blood-thirsty fascist yearning to be free of current societal constraints.)
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To: Red Badger

After the vax nonsense he needs to stfu.


9 posted on 02/25/2022 6:13:46 AM PST by bk1000 (Banned from Breitbart)
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To: Red Badger

Drugs are usually patented early in the development process. A long clinical trial cuts a significant portion of the patent life of the drug. But safety and efficacy are top priorities. It would be nice to see the process streamlined.


10 posted on 02/25/2022 6:22:51 AM PST by Huskrrrr (Alinsky, you magnificent Bastard, I read your book!)
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To: Red Badger

Good observations, but they’re not factoring in the drug companies’ GREED and DISHONESTY. Once those two items are added to the equation, it starts to make sense. I mean, not MAKE SENSE, but it’s more understandable.

The last time I saw a doctor was in 2003 or 2004. I don’t take any prescription medications. I’ve worked in too many clinics and hospitals and stopped trusting the system a long time ago. Do you think I’m nuts? I’ve outlasted a lot of people who heaped scorn on me for not running to the doctor for every little thing. I don’t see people having a good time out there on all these medications and procedures that doctors try to talk you into.

Before my mom started yelling at me about vaccinations she told me with a little laugh, “I had a hip replacement and now I can’t walk anymore!”

I do take vitamins and herbs and some over-the-counter things like Benadryl, aspirin, fiber supplement - really simple stuff. I’ve been taking garlic every day for many years.

I got Mr K (not the one on this forum) to start taking garlic: When I first met him he had a bald place on the top of his head about the size of an audio CD. His hair started growing back and there’s no longer a bald spot - some of the hair even grew back its original color. (He looks like Dr Von Helsing! or Beethoven, sort of.)

And you know I’m NOT the picture of excellent health but on the other hand I’m not laying out hundreds of dollars a month for the ten or twenty pharmaceuticals doctors would have me taking at my age - I mean, they give this stuff to EVERYBODY and you’re supposed to be happy and grateful to have to take like 30 pills a day. And I would be vaccinated and all that happy h0rsesh1t. I think it’s at least probable that one of the reasons I’m still flapping today is the LACK of medical intervention.

The pandemic illustrates this point quite admirably: The most effective treatments and prophylaxis against the SARS-CoV2 are SIMPLE medicines that have been around for A LONG TIME.


11 posted on 02/25/2022 6:34:06 AM PST by Scarlett156 (Vaping is for homosexuals. )
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To: Red Badger

Drug developers are still spending a lot of time and money on the holy grail of pharmacology - female viagra.


12 posted on 02/25/2022 6:37:54 AM PST by Jim Noble (Who saves the nation breaks no law)
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To: Scarlett156
I’m not laying out hundreds of dollars a month for the ten or twenty pharmaceuticals doctors would have me taking at my age

Amen. Nor are you suffering any of the side effects of those drugs.
Listening to the drug commercials on TV is like watching a horror movie.
13 posted on 02/25/2022 6:41:26 AM PST by oh8eleven (RVN '67-'68)
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To: Red Badger
It takes 10 to 15 years and around US$1 billion to develop one successful drug. Despite these significant investments in time and money, 90 percent of drug candidates in clinical trials fail.

Hmmm. I was aware of the rough timeline and costs associated with bringing new drug therapies to market. I did not realize the failure rate was that high.

Given this track record, when it comes to the covid-19 vaccines something is very definitely amiss.

I have no doubt truckloads of cash were spent.

10 to 15 years? These were developed in days (Moderna is particularly proud of how rapidly they developed theirs), tested over the span of mere weeks and approved after just a few years.

All this while 2 of the 3 are utilizing brand new, never before put to widespread use mRNA technology. Obviously corners were cut, procedures ignored or modified. Note, those procedures were put in place to help ensure the safety of the products brought to market. They were learned "the hard way" and they have not been followed in this case.

90% failure rate? Well, the FDA seems to be running either an out-of-character 25% failure rate, or even an astounding 0% failure rate with covid vaccines. I know of 4 that were submitted for approval, 3 are approved, and the 4th is not yet completely out of the running.

Amazing that vaccines developed in such a rush with new technologies could experience such previously unheard of success rates. It's almost like they aren't allowed to fail...

Ok, yes, lightning does strike once in a while. But what is more likely, that vaccines rushed through development, using new technologies, just happen to have been nearly universally successful? Or is it more likely that most, probably even all of these should have failed clinical trials. That they did not can be attributed to rule breaking, corner-cutting, and a flat out dis-interest in following procedures or considering negative data.

If the truth ever comes out people are going to prison over this. Though I doubt we'll ever know the complete story behind this BS. Maybe if enough people start experiencing serious long term side effects there will be enough interest by people with integrity to dig into this fiasco and learn the truth.

14 posted on 02/25/2022 7:07:23 AM PST by ThunderSleeps (Vaccine mandates: they are not about health, they are about obedience.)
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To: oh8eleven

I hate saying things like that about medicines that I know a lot of people can’t live without. But on the other hand, me talking trash about the medical drugs industry isn’t why nobody trusts them anymore - they’re the ones who did that. They did it to themselves.

Almost every medication I remember internal medicine/family practice doctors I’ve worked for giving to people over age 50 has been found to do something bad to you over time - and they give them to EVERYBODY and you’re supposed to take them EVERY DAY. Like Metformin. They were giving that out like candy - very expensive candy - to all kinds of people. And it’s pretty bad, I guess. Anticholinergic medications are another that comes to mind: They are shown over time to cause cognitive impairment. (So you’ll have a heart/bladder problem AND dementia, too!)

If it wasn’t so blatantly obvious at this point that we’re being lied to and played - and in some cases conveniently killed off - then I would just be another conspiracy theorist who likely has a grudge at some doctor. (I DO have a grudge against a medical practitioner, in fact - but it’s over a stalking issue that started when I worked in his office a long time ago.) The pharmaceuticals industry cynically thinks that we are all A) stupid and B) lazy - that is, we are all so lazy that we don’t bother to take care of ourselves, thinking that the doctor will have a pill or treatment that will fix us. Just take the pills, and all will be well!

Drug commercials are just another reason I am glad we don’t have TV.


15 posted on 02/25/2022 7:11:14 AM PST by Scarlett156 (Vaping is for homosexuals. )
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To: antidemoncrat
That has been my observation with so many modern drugs. Unless the med is supposed to cure a critical medical condition or save a life, the problems caused by side effects can outweigh it’s benefits.

That's always been the challenge of pharmaceutical science and the practice of medicine--weighing the risk/benefits for each disease state. Risking death for a drug that helps patients with ED may be considered extreme; risking death for a patient with pancreatic cancer? That's an entirely different risk calculus.

16 posted on 02/25/2022 7:16:21 AM PST by Lou L (Health "insurance" is NOT the same as health "care")
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To: Jim Noble
Drug developers are still spending a lot of time and money on the holy grail of pharmacology - female viagra.

I support this goal.

17 posted on 02/25/2022 7:24:45 AM PST by BipolarBob (The roar of the masses could be "Let's Go Brandon".)
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To: Jim Noble
female viagra.

That thing exists, it's called Chad. And Chad isn't worried about female Viagra, he gets more than he can handle.

Women (and non Chads) want a female Viagra so they can feel about the guy who brings out the garbage and is dependable the way thy feel about the Chad. DTF.

Female psychology is interesting, if nothing else.

18 posted on 02/25/2022 7:54:30 AM PST by riri (Hope is not a strategy at this point- Sam Andrews)
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To: Scarlett156
I got Mr K (not the one on this forum) to start taking garlic: When I first met him he had a bald place on the top of his head about the size of an audio CD. His hair started growing back and there’s no longer a bald spot - some of the hair even grew back its original color. (He looks like Dr Von Helsing! or Beethoven, sort of.)

OK, now you got my attention.
19 posted on 02/25/2022 7:59:38 AM PST by Old Yeller (A nation of sheep, produces a government of wolves.)
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To: Red Badger

“ On average, about 4,500 drugs and devices are pulled from U.S. shelves each year. The recalled products have U.S. Food and Drug Administration (FDA) approval and in many cases, are widely ingested, injected or implanted before being recalled.”

Being approved is only part of the story.

But the FDA is more worried someone may take too much vitamin C and get the runs.


20 posted on 02/25/2022 8:11:50 AM PST by aMorePerfectUnion (Fraud vitiates everything.)
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