I’m not taking anything made after 2000.
I’m going to turn into a hippie and use plants…
About the only thing you can not reasonably make is antibiotics and steroids.
Mild pain killers are also hard to make. Never understood why people in those Apocalypse stories are always so delighted by finding opiates. I can whip up some "knock you for a loop" pain killers in no time.
What is hard is coming up with something like ibuprofen that will take care of aches and pains without leaving you looping or tossing your cookies.