Posted on 02/04/2022 3:28:05 PM PST by Brookhaven
Grapefruits contain a compound that leads to significantly increased levels of medication in your bloodstream. While most medications are safe to use with grapefruit, there are a few that can have serious side effects when absorbed at higher than usual levels.
Several studies have shown that CBD is similar to furanocoumarin (grapefruit) in its ability to inhibit or decrease the activity, of CYPs. While there haven’t been enough studies to determine what the implications of CBD’s CYP-inhibiting effects are, it’s clear that CBD interacts with CYPs in a significant way.
If you’ve never had to worry about grapefruit intake, then you shouldn’t have to worry about CBD interacting with any of your medications. (Just continue to be mindful of your serving size and monitor whether it’s delivering the functional benefits you’re looking for!)
If you have concerns about grapefruit or CBD interacting with your medications, check with your doctor or pharmacist to see if any of the medications you’ve been prescribed are known to interact with furanocoumarins. If the answer is yes but you still want to use CBD, stick with topical CBD or work with your doctor to find the right low dose of CBD that works for you.
(Excerpt) Read more at lazarusnaturals.com ...
i like martha stewart gummies. I have no idea if they do any good but I eat them anyway.
Do you have any idea how grapefruit interacts with the adrenal genetic variations. Seems like I remember p450 being involved with one of the Adrenal Hyperplasia issues
Sertraline also has a warning about Grapefruit products.
its called:
cytochrome P450 oxidoreductase deficiency
good luck getting Drs to check to figure exactly what you have. I was just told -oh hey..you have adrenal hyperplasia...nothing we can do about it.
So, get a prescription for the dose of med that will increase to your desired dosage when you have your grapefruit or juice. Win-win.
You misunderstood the effect of inhibiting P450. If the intended "net" dose of a medication is 50 mg, the actual dose provided will be 100 mg assuming the P450 will degrade half of the dosage provided. If you consume grapefruit juice, the P450 is inactivated. The 100 mg dose arrives undegraded. You have just overdosed by a factor of 2x.
Not the first thing I've misunderstood! Thanks.
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