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Drug cocktail that could be a saviour: New Covid treatment is FOUR TIMES more effective at keeping patients out of intensive care, tests suggest
Daily Mail UK ^ | 28 November 2021 | By HEALTH AND SCIENCE REPORTER FOR THE DAILY MAIL

Posted on 11/29/2021 12:09:32 AM PST by blueplum

A new drug cocktail is four times more effective at keeping Covid patients out of intensive care, initial tests have suggested.

While the steroid dexamethasone was the first drug to be licensed for treating the virus, trials indicate that combining it with heart failure medication spironolactone yields better results.

...The treatment works by ‘turning off’ the impact the virus has on the body, rather than targeting the virus itself.

(Excerpt) Read more at dailymail.co.uk ...


TOPICS: Chit/Chat; Health/Medicine; Science
KEYWORDS: ccpvirus; covid; covid19; dexamethasone; inflamationpathways; siredwards; spidex; spironolactone; treatment
the paper is titled "Follow Your Nose: A Key Clue to Understanding and Treating COVID-19" and you can find it HERE

" this paper reports proof of concept studies in which MR blockade using spironolactone and low dose dexamethasone (SpiDex) was given to PCR-confirmed COVID-19 patients... Further larger controlled studies of inpatients and outpatients are required not only for SARS-CoV-2 infection per se but also to determine if this treatment affects the incidence of Long COVID. " and the question being asked is,

" If it was possible to lower the peri-cellular ATP levels would this inhibit the release of the NLRP3 inflammasome and hence the inflammatory response?"

"Experiments using endothelial cells have shown that activation of the Mineralocorticoid Receptor stimulates the release of ATP, activates purinergic receptors, increases intracellular calcium and hence exocytosis of Weibel-Palade bodies (27). These contain the Von Willebrand Factor (VWF) and angiopoietin-2. These are markedly elevated in patients admitted to hospital with COVID-19 and very high levels are predictive of death. A previous paper suggested that the release of ATP by these cells is a key mechanism underlying the exocytosis of these molecules and hence the major complications of SARS-CoV-2 infection (Acute Respiratory Distress Syndrome and multiple microthrombi) (8)..."

1 posted on 11/29/2021 12:09:32 AM PST by blueplum
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To: blueplum
LOL. Good luck with that.

"Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used as a part of transgender hormone therapy in transfeminine people."-wiki

2 posted on 11/29/2021 2:22:23 AM PST by StAnDeliver (Each of you have at least ONE of these in your 401k: Pfizer, Moderna, AstraZeneca, J&J, and MERCK)
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To: blueplum

Side effects - Anal leakage, no male wood, bleeding out of the ears and eyes, ceaseless faggotry, promiscuity, and favoring Communism...


3 posted on 11/29/2021 3:31:59 AM PST by EEGator
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To: blueplum

Bkmk


4 posted on 11/29/2021 3:47:21 AM PST by sauropod (Meanie Butt Daddy - No you can't)
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To: EEGator

Can’t tell if you left off the /s, so just in case...

Millions of people take aldactone for hypertension, every day, for years, without experiencing the rare side effects you list.

The proposed use of the drug as an adjunct to dexamethasone (which has already saved hundreds of thousands of lives in COVID) is for FIVE DAYS, never to be repeated.


5 posted on 11/29/2021 3:54:00 AM PST by Jim Noble (The nation cannot be saved until the GOP is destroyed)
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To: Jim Noble

I thought it was obvious that I was joking.

I’m pretty sure “ceaseless faggotry” isn’t a side effect of any medication...


6 posted on 11/29/2021 3:57:59 AM PST by EEGator
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To: blueplum

A vaccine a day keep the COVID away.


7 posted on 11/29/2021 3:58:14 AM PST by McGruff
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To: EEGator

“Ceaseless faggotry” appears to be a prerequisite for journalism school these days, though.


8 posted on 11/29/2021 4:00:59 AM PST by MortMan (You better bring yours, when you come to take mine. - Creed Fisher)
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To: MortMan

9 posted on 11/29/2021 4:11:31 AM PST by EEGator
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To: StAnDeliver

It is a potassium sparing diuretic as well so potassium levels will have to be carefully monitored. Would not be a good mix with Remdesivir!


10 posted on 11/29/2021 5:19:32 AM PST by mdmathis6 (Having the Conch shell is no longer recognized by Dem "Flies" as giving one authority to speak.)
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To: blueplum

Ya know what’ll keep Covid patients out of intensive care?

STAY HOME, get your rest, drink your fluids, proper vitamins - like you’ve done with EVERY OTHER time you’ve caught a bug in your lifetime.

What’s killing folks is that they’ve been ordered and conditioned to FEAR FOR THEIR VERY LIVES!!! - the past 2 years by the government and media… So folks get a cough and sniffles and RUN TO THE E.R.

These days, hospitals are a business; when you walk in, they see $$$.


11 posted on 11/29/2021 6:46:46 AM PST by joethedrummer (We can’t vote our way out of this, folks..)
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To: EEGator

Democrats ask, “So what’s the downside”?


12 posted on 11/29/2021 8:05:36 AM PST by BipolarBob (Save the gay whales. They're an endangered species.)
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To: blueplum
trials indicate that combining it with heart failure medication spironolactone yields better results.

Yeah, like they tried combining HCQ + zinc + Azrithomyacin ... with obscene dosages, so no treatments would be available to block the Emergency Use Agreement.

13 posted on 11/29/2021 8:59:46 AM PST by RideForever (One of the CoVID naturally immune control group)
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To: blueplum

“A new drug cocktail is four times more effective at keeping Covid patients out of intensive care, initial tests have suggested.”

four times more effective than WHAT? ... sounds like a bad tv ad from the ‘60s for “little tiny time pills” or some such ...


14 posted on 11/29/2021 2:27:34 PM PST by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: catnipman

poor headline. 4x more effective than dexamethasone alone in hospitalized non-icu

the ‘Spidex’ cocktail, just 5.4 per cent were admitted to intensive care compared to 19.6 per cent of those taking dexamethasone alone.


15 posted on 11/29/2021 3:20:23 PM PST by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: blueplum

“poor headline”

not JUST the headline: i quoted an actual sentence in the article ...


16 posted on 11/29/2021 7:35:34 PM PST by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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