" this paper reports proof of concept studies in which MR blockade using spironolactone and low dose dexamethasone (SpiDex) was given to PCR-confirmed COVID-19 patients... Further larger controlled studies of inpatients and outpatients are required not only for SARS-CoV-2 infection per se but also to determine if this treatment affects the incidence of Long COVID. " and the question being asked is,
" If it was possible to lower the peri-cellular ATP levels would this inhibit the release of the NLRP3 inflammasome and hence the inflammatory response?"
"Experiments using endothelial cells have shown that activation of the Mineralocorticoid Receptor stimulates the release of ATP, activates purinergic receptors, increases intracellular calcium and hence exocytosis of Weibel-Palade bodies (27). These contain the Von Willebrand Factor (VWF) and angiopoietin-2. These are markedly elevated in patients admitted to hospital with COVID-19 and very high levels are predictive of death. A previous paper suggested that the release of ATP by these cells is a key mechanism underlying the exocytosis of these molecules and hence the major complications of SARS-CoV-2 infection (Acute Respiratory Distress Syndrome and multiple microthrombi) (8)..."
"Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used as a part of transgender hormone therapy in transfeminine people."-wiki
Side effects - Anal leakage, no male wood, bleeding out of the ears and eyes, ceaseless faggotry, promiscuity, and favoring Communism...
Bkmk
A vaccine a day keep the COVID away.
Ya know what’ll keep Covid patients out of intensive care?
STAY HOME, get your rest, drink your fluids, proper vitamins - like you’ve done with EVERY OTHER time you’ve caught a bug in your lifetime.
What’s killing folks is that they’ve been ordered and conditioned to FEAR FOR THEIR VERY LIVES!!! - the past 2 years by the government and media… So folks get a cough and sniffles and RUN TO THE E.R.
These days, hospitals are a business; when you walk in, they see $$$.
Yeah, like they tried combining HCQ + zinc + Azrithomyacin ... with obscene dosages, so no treatments would be available to block the Emergency Use Agreement.
“A new drug cocktail is four times more effective at keeping Covid patients out of intensive care, initial tests have suggested.”
four times more effective than WHAT? ... sounds like a bad tv ad from the ‘60s for “little tiny time pills” or some such ...