Posted on 10/19/2021 1:36:11 PM PDT by ConservativeMind
A large proportion of the damaging chemical changes which occur in the body's cells due to diabetes and obesity could be prevented by a naturally occurring molecule, a new study suggests.
In type 2 diabetes, when glucose stays in the blood it is not used as fuel for energy and can instead lead to toxic molecules forming.
Scientists at Nottingham Trent University investigated how this "metabolic stress," resulting from prolonged exposure to high levels of glucose and fat, damages proteins in the blood and cells and prevents them from working properly.
The researchers, writing in the journal Free Radical Biology and Medicine, also studied the effect of "carnosine," a molecule found in human skeletal tissue and consumed in the diet through meat and fish. It can also be taken as a nutritional supplement.
By comparing with the blood of healthy individuals, the team was able to identify disease-associated changes in patients with obesity, type 2 diabetes and gestational diabetes.
Further laboratory work then investigated the extent to which carnosine was able to prevent similar damaging protein modifications in cells and tissues linked to the control of glucose.
The researchers found that carnosine prevented 65–90% of these damaging chemical changes and protected the functional properties of affected cells.
The researchers say that despite the cells being compromised, carnosine was able to preserve cellular function by soaking up the toxic molecules.
"We found that carnosine is able to protect cells that are responsible for controlling blood sugar levels. This increases sensitivity to glucose and also results in greater insulin release.
"While further studies are required, this work has confirmed our hypothesis that carnosine could offer significant therapeutic potential against type 2 diabetes."
(Excerpt) Read more at medicalxpress.com ...
It can reduce blood pressure, so anyone on medicines should review if there could be an issue. I’ll put in a link to more information.
I have been taking carnosine for more than a year, but I can’t directly chalk up my health improvements to just that, but more recent changes roughly coincided with a doubling of it (along with a few other tweaks).
What Is Carnosine? A Potential Antioxidant for Disease Prevention and Beyond:
https://draxe.com/nutrition/carnosine/
ping
More proof that eating good quality beef is good for you.
I dunno... Better run it by Fauci first.
Those of us with type 2....this could be a game-changer!
Dang straight!
Off to do some reading....
The Type 2 game has already been changed with low carb/keto time restricted eating and weekly fasting of 24-48 hours duration.
I belong to a couple of fasting groups and they are filled with people who have reversed Type 2 and are off metformin or insulin.
What is the dose that you take.
500 mg, twice a day, for carnosine.
We also increased our choline and betaine intake to get additional methylation factors, among other tweaks, around that same time, so I don’t know what has been more helpful.
My wife has only recently been able to go an entire day without eating, under keto/low carb. We’ve been doing keto/low carb, but she still had to eat three meals a day, or she got headaches. Her headaches from lack of eating had always occurred, since she was a child.
Anyone find the effective carnosine dosage and frequency used by this study?
It’s highly likely that the problem is dehydration combined with low sodium/potassium/magnesium.
Keto/low carb diets are both naturally dehydrating and salts depleting. Especially when you are eating whole foods rather than high sodium packaged convenience foods.
I generally put a few grains of pink rock salt under my tongue throughout the course of my fasting periods. I still struggle with drinking enough water and remembering to salt my food, since I was trained out of that by standard medical advice. Low sodium, low fat dietary advice was killing me and is still killing others.
But I am off all meds except my BP med which has been reduced to a half tab of a 25mg tab as I continue to lose weight. I hope to be off of it by spring.
I found some of the research details here: http://irep.ntu.ac.uk/id/eprint/42070/1/CHARLIE.LAVILLA%20JR%202020%20excl3rdpartycopyright.pdf
Excerpts follow:
"carnosine treatment (100-200mg/kg) reduced hyperglycaemia, and normalised dyslipidaemia in a streptozotocin diabeticinduced model "
"a diet such as a portion of beef, pork or chicken daily could provide approximately 250 mg per day of carnosine "
yeah I take the choline and betaine too.
What’s your dosage?
Lecithin: 1 1/2 - 2 tablespoons [2-3% is choline, so 15 grams gives 375 mg]
Citicoline: two 250 mg capsules [21.4% is choline, so 500 mg gives 107 mg]
Alpha-GPC: two 300 mg capsules [40.3% is choline, so 600 mg gives 242 mg]
A single egg yolk has 147 mg of choline, which appears to be the densest choline food.
The minimum daily intake was set by the Institute of Medicine for choline to 550 mg for men and 425-550 mg for women. Upper Tolerable Limits are 3,500 mg a day for adults. (Courtesy of Consumerlab.com)
Only citicoline and Alpha-GPC readily cross the blood brain barrier. Other forms need to be converted through a multi-step process to make it there.
TMAO is temporarily increased by double by eating egg yolks, but it immediately goes back down. Phosphatidyl choline [13.7% is choline] appears to be a good source, but choline bitartrate [41.1% is choline] is a bad source, raising TMAO about double in a month of taking 411 mg a day.
For the lecithin, we use NOW Foods Sunflower Lecithin
For the Alpha-GPC, we use Nutricost.
For the citicoline, we are trying Naturebell.
For the carnosine, we use both Doctor's Best capsules and Bulk Supplements bulk powder.
I still wonder if people get type 2 diabetes because they are fat, or get fat because they have type 2 diabetes.
Well, I’d say we push the envelope with sugars/carbs to the point that our insulin can’t dump the calories into muscle or fat fast enough. This overstresses the whole body, which continues to break down in small amounts, everywhere, including the very processes meant to shuttle energy around.
We no longer have to be constantly physical, burning calories. We also have cheap, available carbs that become a more fun choice than veggies and fruits for taste and cost. We used to grow a lot of the food we used in gardens, too.
We were not meant for what has become.
It is slightly pricey, but it is said to prevent cataracts.
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