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Molecule could prevent damaging cell changes caused by type 2 diabetes and obesity (Carnosine “significantly” helped)
Medical XPress / Free Radical Biology and Medicine ^ | Oct. 19, 2021 | Charlie Jr Lavilla et al

Posted on 10/19/2021 1:36:11 PM PDT by ConservativeMind

A large proportion of the damaging chemical changes which occur in the body's cells due to diabetes and obesity could be prevented by a naturally occurring molecule, a new study suggests.

In type 2 diabetes, when glucose stays in the blood it is not used as fuel for energy and can instead lead to toxic molecules forming.

Scientists at Nottingham Trent University investigated how this "metabolic stress," resulting from prolonged exposure to high levels of glucose and fat, damages proteins in the blood and cells and prevents them from working properly.

The researchers, writing in the journal Free Radical Biology and Medicine, also studied the effect of "carnosine," a molecule found in human skeletal tissue and consumed in the diet through meat and fish. It can also be taken as a nutritional supplement.

By comparing with the blood of healthy individuals, the team was able to identify disease-associated changes in patients with obesity, type 2 diabetes and gestational diabetes.

Further laboratory work then investigated the extent to which carnosine was able to prevent similar damaging protein modifications in cells and tissues linked to the control of glucose.

The researchers found that carnosine prevented 65–90% of these damaging chemical changes and protected the functional properties of affected cells.

The researchers say that despite the cells being compromised, carnosine was able to preserve cellular function by soaking up the toxic molecules.

"We found that carnosine is able to protect cells that are responsible for controlling blood sugar levels. This increases sensitivity to glucose and also results in greater insulin release.

"While further studies are required, this work has confirmed our hypothesis that carnosine could offer significant therapeutic potential against type 2 diabetes."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: carnitine; carnosine; diabetes
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Foods can provide small amounts of carnosine, such as meats, but supplementation is the most common approach.

It can reduce blood pressure, so anyone on medicines should review if there could be an issue. I’ll put in a link to more information.

I have been taking carnosine for more than a year, but I can’t directly chalk up my health improvements to just that, but more recent changes roughly coincided with a doubling of it (along with a few other tweaks).

1 posted on 10/19/2021 1:36:11 PM PDT by ConservativeMind
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To: ConservativeMind

What Is Carnosine? A Potential Antioxidant for Disease Prevention and Beyond:

https://draxe.com/nutrition/carnosine/


2 posted on 10/19/2021 1:36:32 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

ping


3 posted on 10/19/2021 1:55:10 PM PDT by ducttape45 ("Righteousness exalteth a nation; but sin is a reproach to any people." Proverbs 14:34)
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To: ConservativeMind

More proof that eating good quality beef is good for you.


4 posted on 10/19/2021 1:55:14 PM PDT by BiglyCommentary
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To: ConservativeMind

I dunno... Better run it by Fauci first.


5 posted on 10/19/2021 2:04:29 PM PDT by HeadOn (Love God. Lead your family. Be a man.)
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To: ConservativeMind

Those of us with type 2....this could be a game-changer!


6 posted on 10/19/2021 2:15:06 PM PDT by maineman ( UN-Vaxxed Patriot living behind enemy lines on the coast of Maine.)
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To: maineman

Dang straight!

Off to do some reading....


7 posted on 10/19/2021 2:41:33 PM PDT by Adder ("Can you be more stupid?" is a question, not a challenge.)
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To: maineman

The Type 2 game has already been changed with low carb/keto time restricted eating and weekly fasting of 24-48 hours duration.

I belong to a couple of fasting groups and they are filled with people who have reversed Type 2 and are off metformin or insulin.


8 posted on 10/19/2021 2:44:15 PM PDT by Valpal1
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To: ConservativeMind

What is the dose that you take.


9 posted on 10/19/2021 2:55:04 PM PDT by ckilmer
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To: ckilmer

500 mg, twice a day, for carnosine.

We also increased our choline and betaine intake to get additional methylation factors, among other tweaks, around that same time, so I don’t know what has been more helpful.


10 posted on 10/19/2021 3:06:38 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Valpal1

My wife has only recently been able to go an entire day without eating, under keto/low carb. We’ve been doing keto/low carb, but she still had to eat three meals a day, or she got headaches. Her headaches from lack of eating had always occurred, since she was a child.


11 posted on 10/19/2021 3:13:10 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
Molecule could prevent damaging cell changes caused by type 2 diabetes and obesity (Carnosine “significantly” helped)

Anyone find the effective carnosine dosage and frequency used by this study?

12 posted on 10/19/2021 3:26:07 PM PDT by JesusIsLord
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To: ConservativeMind

It’s highly likely that the problem is dehydration combined with low sodium/potassium/magnesium.

Keto/low carb diets are both naturally dehydrating and salts depleting. Especially when you are eating whole foods rather than high sodium packaged convenience foods.

I generally put a few grains of pink rock salt under my tongue throughout the course of my fasting periods. I still struggle with drinking enough water and remembering to salt my food, since I was trained out of that by standard medical advice. Low sodium, low fat dietary advice was killing me and is still killing others.

But I am off all meds except my BP med which has been reduced to a half tab of a 25mg tab as I continue to lose weight. I hope to be off of it by spring.


13 posted on 10/19/2021 3:26:22 PM PDT by Valpal1
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To: JesusIsLord
Anyone find the effective carnosine dosage and frequency used by this study?

I found some of the research details here: http://irep.ntu.ac.uk/id/eprint/42070/1/CHARLIE.LAVILLA%20JR%202020%20excl3rdpartycopyright.pdf

Excerpts follow:

"carnosine treatment (100-200mg/kg) reduced hyperglycaemia, and normalised dyslipidaemia in a streptozotocin diabeticinduced model "

"a diet such as a portion of beef, pork or chicken daily could provide approximately 250 mg per day of carnosine "

14 posted on 10/19/2021 3:38:57 PM PDT by JesusIsLord
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To: ConservativeMind

yeah I take the choline and betaine too.

What’s your dosage?


15 posted on 10/19/2021 3:50:45 PM PDT by ckilmer
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To: ckilmer
Per day:

Lecithin: 1 1/2 - 2 tablespoons [2-3% is choline, so 15 grams gives 375 mg]
Citicoline: two 250 mg capsules [21.4% is choline, so 500 mg gives 107 mg]
Alpha-GPC: two 300 mg capsules [40.3% is choline, so 600 mg gives 242 mg]

A single egg yolk has 147 mg of choline, which appears to be the densest choline food.

The minimum daily intake was set by the Institute of Medicine for choline to 550 mg for men and 425-550 mg for women. Upper Tolerable Limits are 3,500 mg a day for adults. (Courtesy of Consumerlab.com)

Only citicoline and Alpha-GPC readily cross the blood brain barrier. Other forms need to be converted through a multi-step process to make it there.

TMAO is temporarily increased by double by eating egg yolks, but it immediately goes back down. Phosphatidyl choline [13.7% is choline] appears to be a good source, but choline bitartrate [41.1% is choline] is a bad source, raising TMAO about double in a month of taking 411 mg a day.

16 posted on 10/19/2021 4:42:02 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ckilmer
For the betaine, we take about 750 - 1,000 mg a day in a scoop from powder (Nutricost).

For the lecithin, we use NOW Foods Sunflower Lecithin

For the Alpha-GPC, we use Nutricost.

For the citicoline, we are trying Naturebell.

For the carnosine, we use both Doctor's Best capsules and Bulk Supplements bulk powder.

17 posted on 10/19/2021 4:49:52 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I still wonder if people get type 2 diabetes because they are fat, or get fat because they have type 2 diabetes.


18 posted on 10/19/2021 4:55:20 PM PDT by dsc (Their swords and every terrible implement of the soldier are the birthright of Americans.)
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To: dsc

Well, I’d say we push the envelope with sugars/carbs to the point that our insulin can’t dump the calories into muscle or fat fast enough. This overstresses the whole body, which continues to break down in small amounts, everywhere, including the very processes meant to shuttle energy around.

We no longer have to be constantly physical, burning calories. We also have cheap, available carbs that become a more fun choice than veggies and fruits for taste and cost. We used to grow a lot of the food we used in gardens, too.

We were not meant for what has become.


19 posted on 10/19/2021 5:20:51 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

It is slightly pricey, but it is said to prevent cataracts.


20 posted on 10/19/2021 5:34:45 PM PDT by matthew fuller (The Satanic Trinity- Obama, Soros and the Chinese Communist Party-FUBO44&46. )
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