Antioxidant drug (supplement?) reverses process responsible for heart attacks and strokes (32-56% reduction in plaques)

Medical XPress / University of Reading / Journal of the American Heart Association ^ | Sept. 9, 2021 | Feroz Ahmad et al

[ConservativeMind]

An antioxidant drug reverses atherosclerosis and could be used to prevent heart attacks and strokes due to clots.

Atherosclerosis is the build-up of fatty deposits in the arteries. When a type of fat called LDL cholesterol becomes oxidized and builds up to form plaques in the artery walls, inflammation and damage increase which can cause the plaques to rupture and cause blood to clot.

These clots can block vital arteries that allow blood to flow to the heart, causing a heart attack, or to the brain causing a stroke.

Previously, researchers at the University of Reading discovered that LDL cholesterol can be oxidized in acidic small 'bags' called lysosomes in immune cells within the artery wall.

Now, Professor David Leake and his team have found that the antioxidant drug, cysteamine, has the power to switch off, and even reverse, this damaging process.

Cysteamine works by accumulating in the lysosomes and stops the oxidation of LDL cholesterol. It is already known to be safe in humans where it's used to treat a rare lysosomal disease called cystinosis.

When the researchers looked at mice with atherosclerosis, those treated with cysteamine had a 32 to 56 percent reduction in the size of atherosclerotic plaques depending on the part of the aorta—the largest artery in the body—that was examined.

Cysteamine decreased the amount of oxidized fat by 73 percent and increased the stability of the atherosclerotic areas. It decreased the proportion of inflammatory white blood cells by 55 percent and increased the area made up of smooth muscle cells by 85 percent, ultimately reducing the chance of plaques rupturing and causing a blood clot.

[ConservativeMind]

Folks, the patented drug, “cysteamine,” is something our bodies make from something else our body makes, “pantetheine,” which is available as a supplement. Pantetheine is the immediate precursor form, which breaks down into simple cysteamine (the drug) and pantothenic acid (Vitamin B5).

If this sounds useful for you, as it does for me, look into pantetheine!

[ConservativeMind]

“Cysteamine is a chemical compound that can be biosynthesized in mammals, including humans, by the degradation of coenzyme A. The intermediate pantetheine is broken down into cysteamine and pantothenic acid. It is the biosynthetic precursor to the neurotransmitter hypotaurine.

https://en.m.wikipedia.org/wiki/Cysteamine

[ETCM]

For later

[Norski]

Possibly to take Taurine.

[Veto!]

I read a book called “Wheat Belly” by Doctor William Davis, a cardiologist, several years ago. He said that if you gave up wheat, your LDL would go down.

I gave it up and my LDL went down 40 points in 2 months. My doc is happy and so am I. Never ever miss wheat. I eat potatoes for starch.

No drugs necessary. Go read the book—your library probably has it. If not, AMZ does: https://smile.amazon.com/Wheat-Belly-Revised-Updated-Weight/dp/1984824945/ref=sr_1_2?crid=1IBE62T2O4YKK&dchild=1&keywords=wheat+belly+revised+and+expanded+edition&qid=1631234783&sprefix=wheat+bell%2Caps%2C239&sr=8-2

[packagingguy]

It seems thiol functional groups are really powerful antioxidants. Lipoic acid and n-acetylcyteine come to mind. Good find.

[ConservativeMind]

Pantethine, the supplement, is two molecules of pantetheine linked by a disulfide bridge.

https://en.m.wikipedia.org/wiki/Pantethine

[Deaf Smith]

Is Pantethine sold under the Equate brand?

[Magic Fingers]

BKMK

[6ppc]

Bookmark

[RummyChick]

My heart scan looked really great. Just a little plaque in one artery.

No idea why it is better than it should be but i do sporadically take this vitamin.

[Bobalu]

Interesting...

[grobdriver]

Bookmark.

[crz]

Pomegranate. And Cumin.

[sauropod]

Bkmk

[perfect_rovian_storm]

Probably not. The Walmart brand that it would be sold under would be Spring Valley, not Equate, but I haven’t seen it there. I doubt it’s widely used enough to make it onto the shelf at Walmart.

[RummyChick]

Might help with covid. Saw a study talking about this drug and glutathione redox

[TChad]

pantethine bump

[FrankRizzo890]

Bookmark

[Bloody Sam Roberts]

Never ever miss wheat. I eat potatoes for starch.

Nor do I but I miss potatoes. Type 2 diabetic. Potatoes are verboten in anything but small amounts. I strive to keep them off the plate. Lots of protein and lots of veg. But man...I sure do miss a good pot of boneless country style rids with potatoes and sauerkraut...stewed in a Dutch oven for 4 hours.

[sigh...]