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Penn Study Details Robust T-Cell Response to mRNA COVID-19 Vaccines—a More Durable Source of Protection
Penn Medicine News ^ | 16 Aug 2021 | Penn Medicine News staff

Posted on 08/22/2021 5:58:40 AM PDT by blueplum

PHILADELPHIA—Messenger-RNA (mRNA) vaccines against the coronavirus that causes COVID-19 provoke a swift and strong response by the immune system’s T cells—the heavy armor of the immune system—according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania. Although recent studies of vaccines tend to focus on the antibody response, the T-cell response is also an important and potentially more durable source of protection—yet little has been reported so far on the T-cell response to COVID-19 vaccines.

In the new study, which appears in the journal Immunity, the Penn Medicine researchers analyzed the T-cell responses in 47 healthy people who received two doses of the Moderna and Pfizer/BioNTech mRNA vaccines.

(Excerpt) Read more at pennmedicine.org ...


TOPICS: Chit/Chat; Health/Medicine
KEYWORDS: chinavirusvaccine; coronavirus; covid19; immunity; mrna; pandemic; tcell; vaccine; vaccines
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Here's the Study

and the 35-page preproof here:
scrollable pdf here

Unlike antibodies, T-cells were shown to be robust regardless of age (see line 299 to end of paragraph in the pre-proof)

1 posted on 08/22/2021 5:58:40 AM PDT by blueplum
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To: blueplum

Penn State.

The same joint that employs Michael Mann.

Snort.


2 posted on 08/22/2021 6:00:17 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: blueplum

I’m not getting something here. If that’s true, why are there so many breakthrough infections?


3 posted on 08/22/2021 6:01:04 AM PDT by Pearls Before Swine
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To: Pearls Before Swine

Consider the source.


4 posted on 08/22/2021 6:01:36 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: blueplum

Natural immunity is durable and robust.

The vax is failing and Pfizer is under 40% effectiveness.
Look at Israel. The vaxed are stacking up at the hospitals and dying.

This study can not apply to the vax. T-cell immunity is durable for natural immunity.

This study is suspect.


5 posted on 08/22/2021 6:02:13 AM PDT by romanesq (TRUSTY THE PLAN! ChiCom Joe is the Plan? Que magnificent! 👹)
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To: mewzilla

Come on, that’s intellectually lazy. Have you even read the research?


6 posted on 08/22/2021 6:02:22 AM PDT by Fury
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To: mewzilla

Actually this is from Penn University (Ivy League), not Penn State


7 posted on 08/22/2021 6:03:29 AM PDT by Sir_Humphrey ( I wiIl not be pushed, filed, stamped, indexed, briefed, debriefed, or numbered! My life is my own!)
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To: mewzilla

47 people isn’t a low sample; it’s an insignificant sample.

The question is why would they publish t? Propaganda.


8 posted on 08/22/2021 6:04:07 AM PDT by romanesq (TRUSTY THE PLAN! ChiCom Joe is the Plan? Que magnificent! 👹)
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To: Fury

Come on, read teh articles? You know that usually isn’t done around here.


9 posted on 08/22/2021 6:05:50 AM PDT by Sir_Humphrey ( I wiIl not be pushed, filed, stamped, indexed, briefed, debriefed, or numbered! My life is my own!)
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To: Sir_Humphrey
I stand corrected! And, no prob! They're no better.

Penn got $258 million in foreign money, and there may be more it hadn’t disclosed

10 posted on 08/22/2021 6:06:52 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: blueplum

47 people doesn’t really seem like a good study


11 posted on 08/22/2021 6:07:04 AM PDT by frogjerk (I will not do business with fascists)
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To: blueplum

Not necessarily true

https://freeworldnews.tv/watch?id=611eba01f4d8bd5dc714cb9b


12 posted on 08/22/2021 6:07:51 AM PDT by stanne
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To: blueplum

Cytokine storms and T cell counts may offer clues on how to treat COVID-19

MARCH 2020

Inflammatory immune response can cause T cells to become depleted, affecting patient outcomes in coronavirus cases and leaving them prone to secondary infection

https://www.eurekalert.org/news-releases/737027

Cytokine storms may affect the severity of COVID-19 cases by lowering T cell counts, according to a new study published in Frontiers in Immunology. Researchers studying coronavirus cases in China found that sick patients had a significantly low number of T cells, a type of white blood cell that plays a crucial role in immune response, and that T cell counts were negatively correlated with case severity.

Interestingly, they also found a high concentration of cytokines, a protein that normally helps fight off infection. Too many cytokines can trigger an excessive inflammatory response known as a cytokine storm, which causes the proteins to attack healthy cells. The study suggests that coronavirus does not attack T cells directly, but rather triggers the cytokine release, which then drives the depletion and exhaustion of T cells.


13 posted on 08/22/2021 6:09:19 AM PDT by tired&retired (Blessings )
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To: Fury

Reading is a bit of an issue with me this morning. Eye problems.

But keep reading.

Penn is no better.

I ALWAYS consider the source.


14 posted on 08/22/2021 6:09:35 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: blueplum

If thats the case then why the need for booster? They plan to give everyone boosters this fall regardless of when they got their initial dose(s), most getting it with their flu shot. And they are planning to push the seasonal swine flu shot this year harder than ever before, even more than 2009.


15 posted on 08/22/2021 6:10:08 AM PDT by Thunder90 (All posts soley represent my own opinion.)
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To: blueplum

The results also showed that the T-cell response in the weeks after mRNA vaccination includes T-cell types normally elicited by natural infection—and in general, natural viral infection is known to be capable of inducing T-cell protection that lasts years and even decades.

And yet the employer vaccine mandates typically make zero provision for natural immunity induced by previous infection. And the CDC remains mum on the topic if not dismissive.


16 posted on 08/22/2021 6:10:55 AM PDT by Flick Lives (We may or may not have reached herd immunity, but we've definitely achieved herd stupidity.)
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To: mewzilla
How the CCP Infiltrates American Universities They’ve given millions of dollars in undisclosed donations.

Penn mentioned.

17 posted on 08/22/2021 6:12:09 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: Pearls Before Swine

I’m going to guess it’s because t-cells are only part of the immune equation? If antibody production is hampered by age or frailness, the immune system will have an overall harder time, like trying to run with a sprained ankle, than if everything is working at the same level? Just guessing, tho.


18 posted on 08/22/2021 6:13:43 AM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: mewzilla

Something else to keep in mind...

There are plenty of American companies and universities that had boots on the ground in Wuhan in late 2019 and early 2020...

Nobody saw anything...?

Nobody said anything...?

Inquiring minds want to know.


19 posted on 08/22/2021 6:13:56 AM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: romanesq

Summary of study does not say if there was a control group or whether those studied were controlled by social class. Without control group it is likely T cells are produced without the Vax. And if the study was done of people who do not smoke, drink alcohol or are diabetic, it is useless. Blood sugar and insulin is a wild card that can change the body response to anything. I wonder who paid for the study?


20 posted on 08/22/2021 6:14:17 AM PDT by WLusvardi (Drudge Fudges)
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