Posted on 06/28/2021 11:43:29 AM PDT by Red Badger
Proton pump inhibitors (PPIs) — a commonly used type of antacid medication — improved blood sugar control in people with diabetes.
Antacids improved blood sugar control in people with diabetes but had no effect on reducing the risk of diabetes in the general population, according to a new meta-analysis published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Type 2 diabetes is a global public health concern affecting almost 10 percent of people worldwide. Doctors may prescribe diet and lifestyle changes, diabetes medications, or insulin to help people with diabetes better manage their blood sugar, but recent data points to common over-the-counter antacid medicines as another way to improve glucose levels.
“Our research demonstrated that prescribing antacids as an add-on to standard care was superior to standard therapy in decreasing hemoglobin A1c (HbA1c) levels and fasting blood sugar in people with diabetes,” said study author Carol Chiung-Hui Peng, M.D., of the University of Maryland Medical Center Midtown Campus in Baltimore, Md.
“For people without diabetes, taking antacids did not significantly alter their risk of developing the disease,” said study author, Huei-Kai Huang M.D., of the Hualien Tzu Chi Hospital in Hualien, Taiwan.
The researchers performed a meta-analysis on the effects of proton pump inhibitors (PPIs) — a commonly used type of antacid medication — on blood sugar levels in people with diabetes and whether these medications could prevent the new onset of diabetes in the general population.
The analysis included seven studies (342 participants) for glycemic control and 5 studies (244, 439 participants) for risk of incident diabetes.
The researchers found antacids can reduce HbA1c levels by 0.36% in people with diabetes and lower fasting blood sugar by 10 mg/dl based on the results from seven clinical trials. For those without diabetes, the results of the five studies showed that antacids had no effect on reducing the risk of developing diabetes.
“People with diabetes should be aware that these commonly used antacid medications may improve their blood sugar control, and providers could consider this glucose-lowering effect when prescribing these medications to their patients,” said study author Kashif Munir, M.D., associate professor in the division of endocrinology, diabetes, and nutrition at the University of Maryland School of Medicine in Baltimore, Md.
Reference: “Effects of Proton Pump Inhibitors on Glycemic Control and Incident Diabetes: A Systematic Review and Meta-analysis” by Carol Chiung-Hui Peng, Yu-Kang Tu, Gin Yi Lee, Rachel Huai-En Chang, Yuting Huang, Khulood Bukhari, Yao-Chou Tsai, Yunting Fu, Huei-Kai Huang and Kashif M Munir, 30 June 2021, The Journal of Clinical Endocrinology & Metabolism. DOI: 10.1210/clinem/dgab353
Other authors of the study include: Yuting Huang and Khulood Bukhari of the University of Maryland Medical Center Midtown Campus in Baltimore, Md.; Yu-Kang Tu of the National Taiwan University and the Taipei Medical University in Taipei, Taiwan; Gin Yi Lee of the Danbury Hospital in Danbury, Conn.; Rachel Huai-En Chang of the Johns Hopkins Bloomberg School of Public Health in Baltimore, Md.; Yao-Chou Tsai of the Taipei Medical University; Yunting Fu of the University of Maryland in Baltimore, Md.
The manuscript received no external funding
Types of PPIs There are many names and brands of PPIs. Most work equally as well.
Side effects may vary from drug to drug.
Omeprazole (Prilosec)
Esomeprazole (Nexium)
Lansoprazole (Prevacid)
Rabeprazole (AcipHex)
Pantoprazole (Protonix)
Dexlansoprazole (Dexilant)
Zegerid (omeprazole with sodium bicarbonate)
I've been taking acid-reflux medications for over 30 years. Nexium, and now Lansoprazole twice a day for several years. Was diagnosed with Type II diabetes in 2000, and been on oral medications since then. A1c has been fine. And my Endocrinologist has never mentioned that the Lansoprazole helps lower my blood sugar. The one medication that has helped my A1c the most is Jardiance. I also lost 16 pounds over the past two years. Didn't really diet, just reduced my intake.
I’ve got Barrett’s esophagus too, and will be on Lansoprazole, for life. I’ll be 74 next month. Nobody else in my family ever had GERD. They were all smokers. I wasn’t. Three died of lung cancer. One of a stroke. And one from heart attack. They were all between the ages of 74 and 51 when they died.
My Barrett’s was bad and progressing to cancer (dysplasia kept getting worse) so my doc got me into a study on cryo-ablation and that worked. I have no barrettes now for five years, give or take (based on annual endoscopies). But to my anatomy is still just bad, I will be on the PPI for life. I’m in my 50s and I’ve already been on it for 14 years or so. I am very concerned about the long term effects. I couldn’t imagine taking that stuff just to control blood sugar.
I’d had real bad heartburn during my 2nd and last pregnancy in 1970-71. It never went away. I went over 20 years with heartburn that I treated with Rolaids. My family doctor at the time wasn’t interested in prescribing me anything. As time went on, I was constantly eating the Rolaids to get rid of the heart burn. I finally changed doctors, and the new one prescribed Nexium for me. I couldn’t believe that a medication could help me so much. Had a gastroscopy last Thursday, and my Barrett’s hasn’t progressed at all, so I don’t have to have another one for three years...which is fine with me.
Glad to hear it. They say with most people it doesn’t progress beyond just Barrets. For a few it goes to low grade dysplasia. For a tiny fraction it goes to high grade dyspasia. And then it’s cancer. I had low grade dysplasia but it was a 9cm long segment of my esophagus which is gigantic so my doc was like ‘yeah, you are going to get cancer from this.’ Then she took care of it. :-)
Glad to hear that. A lot of people don't realize that untreated heartburn can cause cancer of the esophagus.
“It’s the strong stomach acid that causes Barrett’s esophagus that is pre-cancerous, and can kill you.”
It’s the overeating like a pig that causes Barrett’s esophagus that is pre-cancerous, and can kill you.
Funny, my Gastroenterologist said my acid reflux was caused because the lower esophageal sphincter that keeps the acid from coming back up was damaged during pregnancy and childbirth. I'm a 74 year old female who has never, and still doesn't "eat like a pig" as you call it.
Factors related to Barrett's: Family history, smoking, more common among white men, age, being obese, chronic heart burn and acid reflux.
A small piece of raw ginger is good for stomach issues and nose drainage.
No side affects for me.
Stay away from PPIs as though your life depends on it.
Free advice.
PPIs
PPIs?
I couldn’t survive without them unless I had a feeding tube.
Sorry, I see it is defined in the article. Oops!
Since proton pump inhibitors can reduce gastric acid to an unhealthy level, it doesn’t sound like it’s worth taking for a less than 0.33 decrease on a1C’s.
https://www.webmd.com/heartburn-gerd/news/20160608/proton-pump-inhibitor-health-risks#1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463334/
Pepcid is safe and effective, without all the adverse effects.
Or a low carb high fat diet. Good fat of animal origin.
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