Posted on 06/16/2021 8:11:10 PM PDT by ConservativeMind
New findings from Cleveland Clinic researchers show for the first time that the gut microbiome impacts stroke severity and functional impairment following stroke. The results, published in Cell Host & Microbe, lay the groundwork for potential new interventions to help treat or prevent stroke.
The research was led by Weifei Zhu, Ph.D., and Stanley Hazen, M.D., Ph.D., of Cleveland Clinic's Lerner Research Institute. The study builds on more than a decade of research spearheaded by Dr. Hazen and his team related to the gut microbiome's role in cardiovascular health and disease, including the adverse effects of TMAO (trimethylamine N-oxide)—a byproduct produced when gut bacteria digest certain nutrients abundant in red meat and other animal products.
"In this study we found that dietary choline and TMAO produced greater stroke size and severity, and poorer outcomes in animal models," said Dr. Hazen, chair of the Department of Cardiovascular & Metabolic Sciences and director of Cleveland Clinic's Center for Microbiome & Human Health. "Remarkably, simply transplanting gut microbes capable of making TMAO was enough to cause a profound change in stroke severity."
Previously, Dr. Hazen and his team discovered that elevated TMAO levels can lead to the development of cardiovascular disease. In clinical studies involving thousands of patients, they have shown that blood levels of TMAO predict future risk of heart attack, stroke and death -findings that have been replicated around the world. Earlier studies, also led by Drs. Zhu and Hazen, were the first to show a link between TMAO and enhanced risk for blood clotting.
The team found that a gut microbe enzyme critical to TMAO production called CutC drove heightened stroke severity and worsened outcomes.
(Excerpt) Read more at medicalxpress.com ...
Hawaii has some of the longest life expectancy’s
in the USA. If you Health nuts knew how and what
we eat, drink, and carry on you’d be shocked.
Enjoy your dull Veggie/Vegan lives.
Your problem is you worry too much about
death and not enough about living.
Aloha.
I found a study that compares life expectancy’s on Hawaii by zip code. There was a wide variance, from 72’s to high 80’s.
The reasons given for the variance was everything from places to exercise (lack of sidewalks lowered life expectancy) to access to fresh fruits and vegetables vs. fast food restaurants and access to health care.
I wonder if eating kimchee would infuse the gut with heart health probiotics that would overcome the formation of trimethylamine N-oxide?
Mice.
Do mice normally eat cooked red meat?
Veggies help balance the gut bacteria away from the TMAO problem, so adding others should be helpful, too.
"including the adverse effects of TMAO (trimethylamine N-oxide)—a byproduct produced when gut bacteria digest certain nutrients abundant in red meat and other animal products."Did the fake meat industry fund this study? /s
If you can stand kimchee, yes it is excellent source of probiotics. Yogurt isn’t quite that good but it tastes yummy. All yogurt has good-for-you probiotics but Nancy’s Probiotic Yogurt is best. I eat. yogurt every day so just use regular stuff.
LOL. See #26.
“quality sleep, low stress”
After the last year and a half? Yeah, I’ll get right on that.
Or intermittent fasting.
For the last three years, I eat almost nothing BUT meat, fish, eggs, and some dairy.
No veg, no fiber, and I’ve reversed prediabetes, my T is WAY UP, and I’ve lost 55 pounds.
I’m 74, 6’1” and weigh 182. I had the coronary calcium heart scan last year and I have a very low score of 6.
Check out JohnnyP:
https://imgur.com/a/xcVwYHq
https://imgur.com/ukLcfHY
Forget kimchee, take kefir.
The whole anti-meat hysteria is simply junk science. They mix in processed meats with good quality meats and then damn all meat. Good quality beef has a lot of critical and essential nutriments that are are very hard to get from veggie sources.
This is garbage junk research.
https://www.marksdailyapple.com/what-is-tmao/
Excerpt:
Okay, so anything that contains choline or carnitine will increase TMAO, which should in theory increase your risk of heart disease. Right? Let’s go down the list.
Dietary TMAO Precursors and Their Effects On Health
Eggs. The best source of TMAO-precursor choline in our diet—eggs—should absolutely skyrocket TMAO levels. Except it doesn’t happen.
Three eggs a day has no effect on TMAO levels, even as it increases choline levels and HDL cholesterol.
Okay, so maybe the choline slipped past the TMA-producing gut bacteria in that study, but what about if you quickly switch people from eating oatmeal for breakfast to eating eggs. Surely bad things will happen, right?
No. Eating eggs instead of oatmeal has no effect on TMAO levels. It increases carotenoid and choline levels, though.
Liver. Okay, liver has to do the trick. It has high levels of both carnitine and choline. But no: feeding liver (among other foods) to men fails to increase TMAO levels above control.
Carnitine. Forget meat. What if you go straight to the offensive precursor itself and give actual human women a big daily dose of carnitine for, I don’t know, 24 weeks? Surely it will do something bad.
Nope. TMAO skyrockets, an indication that these ladies’ gut bacteria are converting carnitine to TMA and TMAO, but serum C-reactive protein, interleukin-6, L-selectin, P-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and lipid profile markers are completely unaffected. If gut bacterial conversion of carnitine to TMAO is the preeminent risk factor for heart disease, you’d think some of these ladies’ cardiovascular risk factors would have responded. They had half a year to respond. They did not.
Okay, but maybe there’s lag time between TMAO increases and deleterious changes to health. Nope. They followed those same ladies after cessation of carnitine supplementation. Their TMAO levels dropped, but their health markers stayed the same. No change.
And here’s a study where they used carnitine to increase TMAO levels in patients on dialysis. Not only did nothing bad happen, but the carnitine even reduced markers of vascular injuries. Higher TMAO, better health.
Seafood. As I mentioned earlier, fish and shellfish come pre-contaminated with the TMAO precursor TMA. It’s what gives the characteristic fishy odor, and it definitely gets converted to TMAO. In fact, a human study from a few years ago found that feeding people fish spiked TMAO levels by 60 times. A more recent study even concluded that elevated TMAO levels are a reliable marker for cod intake. The more fish you eat, the more TMAO your body will process.
If you’re going to claim that TMAO is dangerous and causes heart disease, you’ll have to make the case that fish is dangerous and causes heart disease. All the evidence we have points in the opposite direction—that fish and shellfish are protective against heart disease.
“I hope I’m covering all my bases. “
“Add exercise to forestall chronic cardio vascular disease.”
As long as you are not doing these things to appease a nagging spouse. Then it has a reverse influence.
Yogurt contains probiotics.
~~~~~~~~~~~~~~~~~
https://www.jpost.com/health-science/could-a-cup-of-yogurt-cure-your-case-of-covid-19-664976
When this article came out, I switched to kefir. I had been putting yogurt on my breakfast cereal forever but I think that kefir is better (and handier since it just gets poured on).
There is plenty of money in probiotics and prebiotics
Hawaii’s numbers are skewed upward by longer lived chinese and japanese—who are likely not red meat eaters. Nor are they particularly fat. Hawaii’s numbers are skewed downward by native hawaiians who eat about like the people in Kentucky and are just as fat.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226016/
most yogurt in stores has huge amounts of sugar—usually at least one or two teaspoons of sugar.
what’s the sugar content of Nancy’s Probiotic Yogurt?
You are a fine looking dude and I hope to be as healthy as you at your age.
Your coronary calcium score is incredible!
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