Ivermectin: Modes of action against SARS-CoV-2 virus replication (Mody et al)
Posted on 05/19/2021 12:37:15 PM PDT by SeekAndFind
New insights into the mode of action of ivermectin against the novel SARS coronavirus.
The previously discussed, WHO-sponsored meta-analysis of ivermectin against covid-19 has now been published as a preprint. It found a highly significant 75% reduction in covid mortality, based on randomized controlled trials only, and will be continually updated with additional trial results.
To date, the mode of action of ivermectin against SARS-CoV-2 has remained somewhat of a mystery. Early studies indicated that ivermectin may inhibit viral protein transportation. But a new US-Canadian study, published in Nature Communications Biology, found that ivermectin is highly effective (>90%) in inhibiting the main enzyme (3CLpro) involved in the replication of SARS-CoV-2 and other RNA viruses (see the chart above).
Another study, submitted to the Journal of Structural Chemistry, found that ivermectin is binding to the spike protein of SARS-CoV-2 and thus may act as a generic antibody. This might explain why ivermectin appears to be highly effective even as a prophylaxis against SARS-CoV-2 infection.
Nevertheless, many patients, and even doctors, continue to be denied access to low-cost and safe ivermectin, especially in Western countries. Others are paying obscenely overcharged prices, visit dubious online merchants, or resort to animal-grade products. If ivermectin is not available locally, it may instead be bought from certified Indian pharmaceutical exporters on Indiamart. However, please note that some countries may not allow its importation.
100 tablets of 12mg ivermectin, enough to treat up to 50 people, cost about $50. And even if SARS-CoV-2 continues to mutate, ivermectin, targeting its replication, should remain effective. The same applies to other early treatment drugs targeting virus entry, replication, or disease progression.
Note: Patients are asked to consult a doctor.
Ivermectin: Modes of action against SARS-CoV-2 virus replication (Mody et al)
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No questions asked at my TSC. They have plenty on hand. They do keep the Ivermectin locked in a glass case with other medicines. There are signs on the case saying the CDC and FDA does not recognize Ivermectin yadayadayada...
Lots of horses around here so no one bats an eye.
According the expiration date it looks like the shelf life is good for two years.
the REAL problem with 1.8% ivermectin horse-paste is that NONE of the manufacturers specify what the other 98.2% ingredients are....
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I agree... that’s a good point and after all, even though one assumes that the manufacturer wouldn’t put anything in that would be harmful to horses (and by extension, humans), that still doesn’t touch the fact that it wasn’t manufactured specifically for humans and thus the ‘human standards’ are not applied.
No questions asked at my TSC.
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Thanks for the information... my other response next to this one was to catnipman about what’s all in the product (standards for horse products are not the same as human products). I guess this all comes down to what’s available and whether my own doctor will give me a prescription. As I said earlier, I only want to have a supply on standby just in case....
How do you get paste into a syringe?
It’s not a needle syringe, more like a long tube with a plunger. Kind of like a caulking gun.
Ping for later
“wasn’t manufactured specifically for humans”
not knowing the other ingredients is the big stopper for me ... best to chuck some extra bucks and get ivermectin via insulinhub.com or see if one can get indiamart.com to work or even one of the U.S. frontline doc groups ...
I can also buy it in my local Walmart, back in the pet department.
I have been buying it there (as well as Tractor Supply) for years, as I use it for my dogs’ heartworm prevention. Basically a couple cents per dose, as opposed to $25 for the Heartguard from the vet. The box and tubes of med are small, so you have to look for them.
My wife and I didn’t start taking it ourselves until last October.
DISCLAIMER - It tastes like CRAP. Now I know why I must trick my dogs into eating it.
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FWIW
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