Posted on 05/04/2021 7:58:04 AM PDT by ConservativeMind
At Baylor College of Medicine, Dr. David J. Durgan and his colleagues are dedicated to better understand hypertension, in particular the emerging evidence suggesting that disruption of the gut microbiota, known as gut dysbiosis, can have adverse effects on blood pressure.
…”Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone rat) model, is different from that in animals with normal blood pressure," said Durgan, assistant professor of anesthesiology at Baylor.
"This result told us that gut dysbiosis is not just a consequence of hypertension, but is actually involved in causing it," Durgan said. "This ground work led to the current study in which we proposed to answer two questions. First, can we manipulate the dysbiotic microbiota to either prevent or relieve hypertension? Second, how are the gut microbes influencing the animal's blood pressure?"
…"These results demonstrated that the alterations to the microbiota induced by fasting were sufficient to mediate the blood pressure-lowering effect of intermitting fasting."
The team discovered that the SHRSP hypertensive animals that were fed normally had lower bile acids in circulation than normotensive animals. On the other hand, SHRSP animals that followed an intermittent feeding schedule had more bile acids in the circulation.
"Supporting this finding, we found that supplementing animals with cholic acid, a primary bile acid, also significantly reduced blood pressure in the SHRSP model of hypertension," Durgan said.
Taken together, the study shows for the first time that intermittent fasting can be beneficial in terms of reducing hypertension by reshaping the composition of gut microbiota in an animal model. The work also provides evidence that gut dysbiosis contributes to hypertension by altering bile acid signaling.
(Excerpt) Read more at sciencedaily.com ...
You have a few years on me. 1963 was the year I started to school.
I remember my Mother having the radio on in the kitchen while I ate breakfast. Seems like I heard “She Wore Blue Velvet” every morning . . . Bobby Vinton, right?
bmp
I went on a keto diet a couple years ago; lost about 25 pounds, in a month or 6 weeks, if I recall. Told my doctor about it; he was impressed, especially with my lower A1C. Now I hear him instructing other patients about the importance of low carb and keto diets, whereas his former instructions consistent mostly of telling patients to try eating less. (Of course, I’m sure he has other patients who told him about their experiences with a keto diet).
Yeah, if you fast long enough, your blood pressure gets real low — like zero
bfl
“(spontaneously hypertensive stroke-prone rat)”
How does this relate to the proverbial notion of
skinny rats living longer? I need some rat pictures
to satisfy my scientific curiosity so as to verify my thoughts.
I’ve done keto a few times and still get about 58% of calories from fat, mostly good. Just read up yesterday on the “Fasting Mimicking Diet.” A quick search for “FMD gut bacteria” looks like good news. Also look at autophagy as a benefit of fasting.
thank you
#4 I can change my gut microbiota by eating pickled eggs and drinking beer.
Looks like you are making pickled beer.... : )
You're a true alchemist. "Pull my finger and I'll make everybody disappear."
A poet and didnt know it.
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