Posted on 05/04/2021 7:58:04 AM PDT by ConservativeMind
At Baylor College of Medicine, Dr. David J. Durgan and his colleagues are dedicated to better understand hypertension, in particular the emerging evidence suggesting that disruption of the gut microbiota, known as gut dysbiosis, can have adverse effects on blood pressure.
…”Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone rat) model, is different from that in animals with normal blood pressure," said Durgan, assistant professor of anesthesiology at Baylor.
"This result told us that gut dysbiosis is not just a consequence of hypertension, but is actually involved in causing it," Durgan said. "This ground work led to the current study in which we proposed to answer two questions. First, can we manipulate the dysbiotic microbiota to either prevent or relieve hypertension? Second, how are the gut microbes influencing the animal's blood pressure?"
…"These results demonstrated that the alterations to the microbiota induced by fasting were sufficient to mediate the blood pressure-lowering effect of intermitting fasting."
The team discovered that the SHRSP hypertensive animals that were fed normally had lower bile acids in circulation than normotensive animals. On the other hand, SHRSP animals that followed an intermittent feeding schedule had more bile acids in the circulation.
"Supporting this finding, we found that supplementing animals with cholic acid, a primary bile acid, also significantly reduced blood pressure in the SHRSP model of hypertension," Durgan said.
Taken together, the study shows for the first time that intermittent fasting can be beneficial in terms of reducing hypertension by reshaping the composition of gut microbiota in an animal model. The work also provides evidence that gut dysbiosis contributes to hypertension by altering bile acid signaling.
(Excerpt) Read more at sciencedaily.com ...
Amazingly, supplementing with bile acid reduced blood pressure, regardless of bad bacteria. You can buy such supplements (perhaps something like Jarrow “Bile Acid Factors”).
Do note that chronic high blood pressure remodels vascular walls and other damage from soft and hard calcium plaques can semi-permanently keep blood pressure higher than normal. There are approaches to reduce soft and hard plaques separate from this study’s scope.
Interesting - so excess acid in the stomach (bile) makes its way into the bloodstream and somehow lowers blood pressure. (Maybe acting as a “cleaning agent” in the blood and thinning it out?
The stomach does not produce any bile.
The bile duct, which comes after and separate from the stomach, releases it.
I can change my gut microbiota by eating pickled eggs and drinking beer.
Wife does not particularly like it afterwards though.
Follow this guy on Twitter.
I don't know where he finds all the research papers that he does.
I am a heart patient who had bypass surgery in 2017. My cardiologist has been telling me for the last few years that researchers were discovering that gut bacteria was suspected of having a big impact on heart disease. Last month, when I went to the pharmacy to pick up meds, my family doctor had called in a prescription for a probiotic. I assumed the verdict is in on gut bacteria influencing heart disease. I think I have an appointment later this month with my family doctor and this will be a topic of discussion.
Not a doctor, but I think the pancreas produces the bile and it is stored in the gall bladder. Don’t quote me for a medical book, though. . . .
This is a game changer!...................
Me too!....................... My wife eats them too!...........
Bile ducts carry bile from the liver to the gall bladder, then also from the gall bladder to the small intestine.
I was researching HCL with Pepsin...which hub has to take (and I’ve started taking) and one article mentions how it can help heart health...fwiw
Liver produces bile.
Gallbladder stores and concentrates bile.
Bile enters duodenum along with stuff from pancreas immediately below stomach.
Eighth grade anatomy and physiology.
Interestingly, these mice have high blood pressure due to a kidney issue, according to Wikipedia.
https://en.m.wikipedia.org/wiki/Spontaneously_hypertensive_rat
So fasting or bile addition mitigates a common form of high blood pressure.
Look into kefir
You could try a supplement or fasting now and see how that helps.
It would be a harmless test. Your doctor won’t likely know about this study.
Absolutely! Kefir is great for the gut. Can resolve heartburn and indigestion in the process.
So easy to get some grains online, then make and serve yourself a cup of it daily. Even the name “kefir” supposedly comes from the Turkish word for “feels good”, because of how it makes you feel good after you eat/drink it.
Should have known. The 8th grade was a lifetime ago- 1970
I dramatically improved my metabolic health by eating only one low carb meal per day. My numbers went from the doctor scolding me to her now asking me questions about how I did it. In spite of my success, she still tells me I eat too much cholesterol.
no kidding - 63 here.
I was still trying to find out how many baseball cards I could attach to the spokes of my bike to make that neat sound.
Good for you!
We have to have 1,000 - 1,500 mg of cholesterol a day or we will have to make it ourselves in our liver.
It’s hard to eat foods with 1,500 mg of cholesterol a day. That’s 7.5 - 8 eggs.
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