Posted on 02/10/2021 7:48:22 PM PST by SeekAndFind
The results of the so called STOIC clinical trial run by Oxford University and testing budesonide have just been published as a pre-print on medrxiv.
The study concludes that “Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery following early COVID-19 infection.”
“We have demonstrated that the inhaled glucocorticoid, budesonide, given for a short duration, may be an effective treatment of early COVID-19 disease in adults. This effect, with a relative reduction of 90% of clinical deterioration is equivalent to the efficacy seen following the use of COVID-19 vaccines and greater than that reported in any treatments used in hospitalised and severe COVID-19 patients.”
This is a particularly important result not only because this effectiveness is achieved with a single agent – budesonide – but also because it is achieved on an outpatient basis.
The rationale of this budesonide study is explained in the study’s description:
“Early data from multiple studies in China, where the virus originated, show that severe cases of CoVID-19 are not as prevalent in patients with chronic lung diseases as expected. This is similar to findings from Italy and the US. We think that the widespread use of inhaled corticosteroids may be reducing the risk of severe CoVID-19 infection in patients with chronic lung disease. Early experimental data also shows that inhaled corticosteroids are effective at slowing down the rate of coronavirus replication on lung cells.”
“Inhaled corticosteroids are widely used to manage common lung conditions, such as asthma and chronic obstructive lung disease. This type of medicine is among the top 3 most common medication prescribed around the world. These medicines are safe, the way inhaled steroids work is well understood, and the potential side effects are mild and reversible.”
“We propose to test the idea that, in participants early in the course of CoVID-19 illness, daily inhaled corticosteroids for a maximum of 28 days, will reduce the chances of severe respiratory illness needing hospitalisation. We will also study the effect of this inhaled therapy on physiology, symptoms and the amount of virus that is shed.”
For this study, the authors:
“conducted a randomised, open label trial of inhaled budesonide, compared to usual care, in adults within 7 days of the onset of mild Covid-19 symptoms. The primary end point was COVID-19-related urgent care visit, emergency department assessment or hospitalisation.”
The study only got 146 (out)patients to undergo randomization, yet
“The trial was stopped early after independent statistical review concluded that study outcome would not change with further participant enrolment.”
Note that budesonide has been used for over half a year, off-label, particularly in the US, as discussed by Dr Richard Bartlett and Dr Mobeen Syed in the video referenced below.
Budesonide is also part of the early treatment algorithm developed by Dr Peter McCullough and collaborators.
https://www.medrxiv.org/content/10.1101/2021.02.04.21251134v1
https://pubmed.ncbi.nlm.nih.gov/33387997/
Watch also this excellent HighWire program with Dr Bartlett.
Ping for your interest
Bravo to these guys for showing this.
Thank you!
CDC has been hiding how many effective treatments now? A DOZEN?
D
Zinc
Quercetin
ECGC
Ivermectin
C
Famotidine
Melatonin
Budesonide
Bs (several)
Hydroxychlorquine (less evidence, but still)
Others?
fluvoxamine
Metformin
Prednisone
Lactoferrin (maybe)
Colchicine
Bromhexine and nitazoxanide (not as well known in the US, but OTC in the EU and UK)
Doxazosin
so far
That’s what the Oxford RECOVERY trial chose to test. Probably nothing nefarious, it was a good bet, and it panned out. Turns out some other things might be better though.
Gawd this covid is so fracking curable it’s a joke!
This drug is not a cure for Covid-19. It looks like the drug reduces inflammation, which reduces symptoms. When the symptoms are reduced, the patient’s body has more energy to fight the virus.
I had wondered why people with asthma did not have extremely serious Covid-19 disease. It makes sense, that their anti-inflammatory inhalers were decreasing their symptoms.
Could you find exact dosage used in this study?
bkmk
AT this moment...Pulmicort is a SOC for Covid patients
bkmk
"Budesonide inhaled via dry powder inhaler, 400 micrograms per inhalation, 2 inhalations twice a day"--STerOids in COVID-19 Study(STOIC), catalogued at clinicaltrials.gov, study #NCT04416399.
I do not know much about inhalers, though, so I am assuming that the dosage is typically found in inhalers prescribed to asthmatics.
The irony here isn’t that steroids have been proving useful in the inflammatory state of the CCP virus. That much was sufficiently obvious that some family physicians were reaching for them very early on in the pandemic.
In the case of Budesonide, a doctor in Midland, Texas, was mocked, shamed, and cancelled back in April for daring to urge his colleagues to consider prescribing it early in the course of the disease, citing his own positive results in his practice.
Somehow, what had been standard in medicine for, well, forever (early treatment, reliance on clinical judgement, use of low-risk, known safe drugs) suddenly became recklessly irresponsible.
The only question left is this: cui bono?
I’ve used budesonide & formoterol since last spring. It replaced the Advair disc I had previously been using. I was short of breath and had a few other odd symptoms for a couple of months early last year. It felt different than asthma and lasted for most of January and February. In retrospect I’ve wondered if I had an early, mild case. But probably not, I had a low grade temperature and no cough.
Two puffs twice a day is the recommended dosage for my budesonide inhaler. I don’t use it that often, much to the chagrin of my doctors. I tend to be drug sensitive and I’ll use the minimum that gives me relief while sparing me side effects. This isn’t an antibiotic so I don’t see a problem if a lower dose works for me.
I seen this last night about this study
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