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New Study Further Confirms Ivermectin's Effective Prophylaxis for COVID-19
Covexit: Covid-19 News and Policy Analysis ^ | 01/13/2021

Posted on 02/07/2021 11:21:47 AM PST by SeekAndFind

Imagine a moment you want to become a trapezist. First thing you need is a safety belt. But it’s not enough. That’s why there is a safety net. Your risk still exists but becomes minimal. // voir version française ici.

Let’s do an analogy.  Your immunity is your safety belt.  But now let’s provide you not just one but three safety nets, stacked over each other, to protect you from C19.  Do you think you are still at high risk of severe disease or death?

The three safety nets are prophylaxis, early outpatient treatment, and hospital treatment.

This article focuses on prophylaxis, which is still little known, and little used, yet is now shown by several studies to be effective to largely prevent C19, including in its severe forms.


Results of a new study out of Argentina have been released and show a substantial prophylactic effect of ivermectin combined with Iota-Carrageenan, administered in 6 sprays per day.

The study was carried out by the ministry of public health of the Tucuman province, with as principal investigator Dr Rossana E Chala, MD, Ph.D., an employee of the ministry.

https://www.clinicaltrials.gov/ct2/show/NCT04701710

This is a randomized controlled trial with 234 health care workers participants, half of which received the treatment of Ivermectin orally 2 drops of 6 mg = 12 mg every 7 days, and Iota-Carrageenan 6 sprays per day for 4 weeks.

In the treatment group, only 4 out of of 117 participants (3.4%) tested positive during the study period, while in the non-treatment / control group, 25 out of 117 participants, or 21.4%, tested positive. This was found to be statistically significant with a p-Value of 0.0001.

The 4 participants in the treatment group who got C19 only developed a mild form of the disease. This contrasts with the placebo group, where out of the 25 participants who were found infected, six developed moderate symptoms and 3 developed severe symptoms.

Study results at a glance, by @Covid19Crusher

What is the reduction in the risk of developing C19 that is procured by the prophylaxis? It can be roughly estimated at (21.4%-3.4%) / 21.4% =  84%. 

What’s even more important is to analyze the risk reduction of developing a severe form of the disease, and while the study size is not sufficient to properly estimate it, it is 100% according to the presented data.

https://clinicaltrials.gov/ct2/show/results/NCT04425850

The study confirms non-randomized results obtained previously in Buenos Aires in a study by Prof. Hector Carvallo, who developed the concept of an ivermectin + carrageenan cocktail for the prophylaxis of C19.

Note that the relevance of using carrageenan is well established, even if it’s unclear how much it adds to the protective effect of Ivermectin.

https://pubmed.ncbi.nlm.nih.gov/25411637/

The results of this prophylaxis study are very important as they show how such innocuous and cheap treatment can considerably reduce the likelihood of developing C19, especially a severe form of the disease, which is exactly what needs to be avoided.

While a weekly dose of Ivermectin is a convenient frequency for taking the drug, one drawback with the protocol, however, is the 6 sprays per day that are foreseen. It’s unclear how adherence to these frequent sprays can be adhered to in practice.

Contrast with Bangladesh Study

How is this study comparing with others? A particularly interesting one was carried out by Tarek Alam et al. in Bangladesh.

The study involved 118 health care workers, with 60 in the control and 58 in the treatment group. The treatment consisted of a monthly dose of Ivermectin, of 12 mg, i.e. a dosage about 4 times lower than with the new Argentinian study.

The treatment was studied for 4 months. There was no usage made of iota-carrageenan. 

Note that with Ivermectin, it’s not only the dosage that counts, but also the frequency, as the agent has a particularly short half life, usually estimated at less than a day.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751445

In the control group of this Bangladesh study, a very large number of participants — 44 out of 60, or 73.3% – became symptomatic and confirmed positive via PCR testing. 

On the other hand, in the treatment group, there were only 4 out of 58 health care workers who got infected (6.9%) – a major difference that was found statistically significant.

The study does not comment on the severity of symptoms in the control group, yet indicates that all 4 infected in the treatment group “had mild symptoms with low grade fever, dry cough and  weakness.” 

What was the reduction in risk of developing C19? Even if the study size may be insufficient, it can be estimated, from the provided data, at (73.3% – 6.9%) / 73.3% = 90.6%. 

Regarding the reduction in the risk of developing a severe form of the disease, it appears, like with the Argentinian study, and with the same caveats, to be 100%.

https://www.ejmed.org/index.php/ejmed/article/view/599/337

There are other studies about Ivermectin-based prophylaxis, as listed at https://c19ivermectin.com/#prep

All of this points at a genuine protective effect of ivermectin as a prophylactic agent for C19. As emphasized by Kory at al, and others, the drug has a strong safety record with rare side effects.

https://osf.io/wx3zn/

Ivermectin is a generic drug listed by the World Health Organization as an essential medicine. The drug is so safe that it has been used for mass treatment of onchocerciasis (river blindness) in Africa, including for children and for pregnant women.

While there is strong evidence of Ivermectin being a potent prophylactic, there remains some uncertainty about the best treatment dosage and frequency, and the added value of carrageenan.

While the Bangladesh study frequency of one intake per month of 12 mg of Ivermectin, alone, may be not enough, it may be possible that the Argentinian regimen, of 12 mg of Ivermectin per week may be too much. 

But some experts also suggest, informally, lower doses to be taken twice a week, to address the issue of the short half-life of Ivermectin.

Note that the colleague of Dr Kory, Professor Marik, who is the author of the iMask+ protocol, currently recommends 1 dose every other week, but that’s a revision from a previous recommendation of one dose per month.

https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-I-MASK-Protocol-v7-2020-12-27-ENGLISH.pdf

In Professor Marik’s protocol, the 12 mg dosage corresponds to an individual of 60 kg, at 0.2 mg per kg of bodyweight. 

There are of course issues with precise dosages, as the pills typically come in 3 or 6 mg.

More studies are needed to determine more precisely all the parameters, yet, as Ivermectin is such a safe and well-known agent, it is entirely possible for medical doctors to issue, today, prescriptions for prophylaxis, by relying on the best available literature.

With the clear effectiveness of Ivermectin as a prophylactic agent, the use of placebos in studies should be avoided, for ethical reasons that should be obvious to everyone. The emphasis should rather be put on different dosages, frequencies and combinations with carrageenan and possible other agents.

Three Safety Nets

Today, there are no good excuses left for not offering Ivermectin-based prophylaxis to high risk individuals, be them health care workers, bus or taxi drivers, meat packing workers, call center employees, high school teachers, university lecturers, overweight and other high risk adults or older people, especially in the extremely high risk nursing homes.

For high risk individuals, Ivermectin offers the opportunity of a first safety net, a bit like vaccination, yet much less expensive, with a much better known safety profile, and much easier to roll out on a large scale.

As discussed extensively in this blog, in the rare cases prophylaxis would not prevent the disease, an early outpatient treatment protocol, such as the one developed by Professor Thomas Borody, combining Ivermectin, Doxycycline and Zinc, can be started, within days of first symptoms. Early treatment is the second safety net.

Australian GPs Can Legally Prescribe Ivermectin Triple Therapy Protocol — Professor Thomas Borody

And then, in the unlikely case the disease has not yet been stopped, the third safety net, constituted by hospitalization, can then be activated. 

With effective prophylaxis (or vaccination), early treatment and hospital treatment, we have three safety nets to combat C19. 

If these safety nets are being properly taken advantage of, it seems highly unlikely anyone would fall through the three of them.

Hospitalization for C19 would then become highly uncommon, contrary to now, where it’s used in most countries as a first, yet high mortality and extremely costly, safety net.

The core problem in the fight against C19 in most countries is that they rely either exclusively, or mostly, on ineffective measures such as lockdowns, and on high mortality hospital treatment. These countries have so far denied the population, including high risk individuals, both prophylaxis and early outpatient treatment.

The infection reported today of 7 nursing home patients in Montreal, having already received a first shot of vaccination, is a reminder that we are still very far from vaccination to provide widespread protection and prevent mortality.

https://montrealgazette.com/news/local-news/maimonides-records-seven-covid-19-cases-after-first-dose-vaccinations

Implementing targeted risk-stratified prophylaxis and early treatment is probably what’s most urgent to fundamentally modify the trajectory of this pandemic, to prevent the disease to become acute, to reduce contagion, to reduce hospitalizations and to reduce mortality.

And along with the immunity to C19 that is steadily building in the population, in addition to vaccination, this would provide a much faster and much less deadly way out of the pandemic.


TOPICS: Health/Medicine; Science; Society
KEYWORDS: argentina; chinavirustreatment; covid19; ivermectin; prophylaxis
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1 posted on 02/07/2021 11:21:47 AM PST by SeekAndFind
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To: Mrs. Don-o; tellw; Huskrrrr; Jane Long; Freedom'sWorthIt; Freedom56v2; BDParrish; Phx_RC; cba123; ..

Ping for your interest


2 posted on 02/07/2021 11:22:26 AM PST by SeekAndFind
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To: SeekAndFind

Better than the vaccine scheme.


3 posted on 02/07/2021 11:29:32 AM PST by Gahanna Bob
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To: SeekAndFind

I have been giving this to my dogs for heartworm prevention for nearly a half century.

Of course, they are chewables, taste like meat, and are a doggie dosage.

But it’s the same stuff.


4 posted on 02/07/2021 11:31:05 AM PST by left that other site (If you do not stand firm in your faith, you will not stand at all. (Isaiah 7:9))
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To: SeekAndFind

I have not researched this specific claim but I will tell you that Betadine has a spray with this ingredient but it isnt sold in the US

You can find it on Amazon for a big price. Dont know if they ship to US.

here is info on it

http://sg.betadine.com/en/sg/cold-and-flu/betadine-cold-defence-nasal-spray


5 posted on 02/07/2021 11:39:05 AM PST by RummyChick (To President Trump: https://freerepublic.com/focus/f-chat/3923111/posts)
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To: SeekAndFind

bkmk


6 posted on 02/07/2021 11:45:00 AM PST by sauropod (#ImpeachMcConnell. #Resist. #NotMyPresident.)
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To: RummyChick

I bet you can do almost as well by irrigating your nasal passages with a solution of hydrogen peroxide

No notes in these studies about the participants taking daily VitD3, Vit C, zinc and quercetin


7 posted on 02/07/2021 11:47:33 AM PST by silverleaf (In a time of universal deceit, telling the truth is a revolutionary act.)
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To: silverleaf

maybe but I dont trust that it wouldnt damage my nose

I use PVP iodine with saline

or i dilute it a little with saline and swab my nose

I have a Dr appointment with an ENT soon and going to ask if it will damage my nose


8 posted on 02/07/2021 11:51:31 AM PST by RummyChick (To President Trump: https://freerepublic.com/focus/f-chat/3923111/posts)
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To: left that other site
You could give it to them cheaper this way.

https://www.tractorsupply.com/tsc/product/durvet-ivermectin-paste-187-608-g

The plunger is graduated in fifty-pound increments.


9 posted on 02/07/2021 12:02:55 PM PST by E. Pluribus Unum (You are in far greater danger from authoritarian government than you are from a seasonal virus.)
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To: E. Pluribus Unum

There’s a tractor supply right near me.

Thanks for the tip.


10 posted on 02/07/2021 12:04:21 PM PST by left that other site (If you do not stand firm in your faith, you will not stand at all. (Isaiah 7:9))
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To: E. Pluribus Unum

Yes, my tractor supply said the reason they keep this cheap stuff locked up is because it is high theft due to people using it on dogs.


11 posted on 02/07/2021 12:06:39 PM PST by RummyChick (To President Trump: https://freerepublic.com/focus/f-chat/3923111/posts)
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To: left that other site

We need a good bacon ivermectin!


12 posted on 02/07/2021 12:07:41 PM PST by aMorePerfectUnion (I'd rather be anecdotally alive than scientifically dead... )
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To: aMorePerfectUnion
We need a good bacon ivermectin!

In Gummy Form. :-)
13 posted on 02/07/2021 12:08:41 PM PST by left that other site (If you do not stand firm in your faith, you will not stand at all. (Isaiah 7:9))
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To: RummyChick

Why don’t they just buy it?

You don’t have to prove you have a horse to buy it.


14 posted on 02/07/2021 12:08:47 PM PST by E. Pluribus Unum (You are in far greater danger from authoritarian government than you are from a seasonal virus.)
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To: SeekAndFind

BFLR


15 posted on 02/07/2021 12:10:20 PM PST by musicman (The future is just a collection of successive nows.)
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To: SeekAndFind

A six spray a day prophylactic?

What’s the point. Team it up on a study with something we already know works, use a mess of it, and then sell a mess of it?


16 posted on 02/07/2021 12:11:18 PM PST by 9YearLurker
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To: SeekAndFind

PING


17 posted on 02/07/2021 12:29:20 PM PST by Rumplemeyer (The GOP should stand its ground - and fix Bayonets)
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To: 9YearLurker

where did you get ‘six sprays a day’?


18 posted on 02/07/2021 12:30:23 PM PST by Bob434
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To: 9YearLurker

nm, i missed that part of the article- i see it now-


19 posted on 02/07/2021 12:31:04 PM PST by Bob434
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To: SeekAndFind

Bookmark


20 posted on 02/07/2021 12:36:56 PM PST by airborne (I don't always scream at the TV but when I do it's hockey season!)
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