The American Journal Of Medicine Now Recommends Hydroxychloroquine For COVID-19

Principia Scientific International ^ | 01/26/2021

[SeekAndFind]

The American Journal of Medicine now (Jan. 2021) now recommends Hydroxychloroquine, Azithromycin, and Zinc for the treatment of Covid 19 outpatients.

The irony is this is the treatment that former US President, Donald Trump promoted last year. The timing, right after the election, is interesting.

Select extracts are below:

Abstract

Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death.

…

This article outlines key pathophysiological principles that relate to the patient with early infection treated at home. Therapeutic approaches based on these principles include 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy, and 5) administration of oxygen, monitoring, and telemedicine. Future randomized trials testing the principles and agents discussed will undoubtedly refine and clarify their individual roles; however, we emphasize the immediate need for management guidance in the setting of widespread hospital resource consumption, morbidity, and mortality.

….

Zinc Lozenges and Zinc Sulfate

Zinc is a known inhibitor of coronavirus replication. Clinical trials of zinc lozenges in the common cold have demonstrated modest reductions in the duration and or severity of symptoms.¹⁸ By extension, this readily available nontoxic therapy could be deployed at the first signs of COVID-19.¹⁹ Zinc lozenges can be administered 5 times a day for up to 5 days and extended if needed if symptoms persist. The amount of elemental zinc lozenges is <25% of that in a single 220-mg zinc sulfate daily tablet. This dose of zinc sulfate has been effectively used in combination with antimalarials in early treatment of high-risk outpatients with COVID-19.²⁰

Antimalarials

Hydroxychloroquine (HCQ) is an antimalarial/anti-inflammatory drug that impairs endosomal transfer of virions within human cells. HCQ is also a zinc ionophore that conveys zinc intracellularly to block the SARS-CoV-2 RNA-dependent RNA polymerase, which is the core enzyme of the virus replication.²¹ The currently completed retrospective studies and randomized trials have generally shown these findings: 1) when started late in the hospital course and for short durations of time, antimalarials appear to be ineffective, 2) when started earlier in the hospital course, for progressively longer durations and in outpatients, antimalarials may reduce the progression of disease, prevent hospitalization, and are associated with reduced mortality.22, 23, 24, 25 In a retrospective inpatient study of 2541 patients hospitalized with COVID-19, therapy associated with an adjusted reduction in mortality was HCQ alone (hazard ratio [HR] = 0.34, 95% confidence interval [CI] 0.25-0.46, P <0.001) and HCQ with azithromycin (HR = 0.29, 95% CI 0.22-0.40, P <0.001).²³ HCQ was approved by the US Food and Drug Administration in 1955, has been used by hundreds of millions of people worldwide since then, is sold over the counter in many countries, and has a well-characterized safety profile that should not raise undue alarm.^25,26 Although asymptomatic QT prolongation is a well-recognized and infrequent (<1%) complication of HCQ, it is possible that in the setting of acute illness symptomatic arrhythmias could develop. Data safety and monitoring boards have not declared safety concerns in any clinical trial published to date. Rare patients with a personal or family history of prolonged QT syndrome and those on additional QT prolonging, contraindicated drugs (eg, dofetilide, sotalol) should be treated with caution and a plan to monitor the QTc in the ambulatory setting. A typical HCQ regimen is 200 mg bid for 5 days and extended to 30 days for continued symptoms. A minimal sufficient dose of HCQ should be used, because in excessive doses the drug can interfere with early immune response to the virus.

Azithromycin

Azithromycin is a commonly used macrolide antibiotic that has antiviral properties mainly attributed to reduced endosomal transfer of virions as well as established anti-inflammatory effects.²⁷ It has been commonly used in COVID-19 studies initially based on French reports demonstrating markedly reduced durations of viral shedding, fewer hospitalizations, and reduced mortality combination with HCQ as compared to those untreated.^28,29 In the large inpatient study (n = 2451) discussed previously, those who received azithromycin alone had an adjusted HR for mortality of 1.05, 95% CI 0.68-1.62, and P = 0.83.²³ The combination of HCQ and azithromycin has been used as standard of care in other contexts as a standard of care in more than 300,000 older adults with multiple comorbidities.³⁰ This agent is well-tolerated and like HCQ can prolong the QTc in <1% of patients. The same safety precautions for HCQ listed previously could be extended to azithromycin with or without HCQ. Azithromycin provides additional coverage of bacterial upper respiratory pathogens that could potentially play a role in concurrent or secondary infection. Thus, this agent can serve as a safety net for patients with COVID-19 against clinical failure of the bacterial component of community-acquired pneumonia.^31,32 The same safety precautions for HCQ could be extended to azithromycin with or without HCQ. Because both HCQ and azithromycin have small but potentially additive risks of QTc prolongation, patients with known or suspected arrhythmias or taking contraindicated medications or should have more thorough workup (eg, review of baseline electrocardiogram, imaging studies, etc.) before receiving these 2 together. One of many dosing schemes is 250 mg po bid for 5 days and may extend to 30 days for persistent symptoms or evidence of bacterial superinfection.

Read the full study at www.sciencedirect.com

[Forward the Light Brigade]

So—They let people die to get rid of Trump? Looks that way. Evil, pure Evil. They will do anything to stop him—Even if they must nuke Florida to do it. The Hate is that deep.

[Sacajaweau]

Looks like Fauci didn’t know what the hell he was talking about when he called any HCQ results as invalid...While at the same time effectively saying a whole bunch of Doctors are stupid.

[chopperk]

Dr. Fauci and Associates need their cajones removed for downplaying HCQ, Zinc Sulfate and Azithromycin last March when President Trump proposed its effectiveness. It could have saved millions of lives. These bastards should be put on trial and convicted for the deaths they caused.

[chopperk]

Get rid of Fauci; he is responsible for millions of deaths due to Covid 19.

[SeekAndFind]

RE: Get rid of Fauci; he is responsible for millions of deaths due to Covid 19.

You can’t. He is Joe Biden’s pet right now.

[Sacajaweau]

HCQ was stupid cheap. Fauci couldn't kiss the Pharm industry with a nickel dime treatment.

The other thing he tried to pull off was that you don't want to cause a shortage for the people who already take this drug for other things. There were millions of doses available and easily produced.

Then there were the masks....Only N95 was good enough said Doctor Fauci...but worried about supply for health care workers so no masks for you. Really?? Then why do they NOW say regular surgical masks are sufficient. Well, they were until last week when Fauci decided we should be wearing two masks.

[mcshot]

Yup, that be the one. She’s especially proud that the dazed, fraudulent one is following her EO lead.

[Sacajaweau]

https://www.republicworld.com/world-news/us-news/covid-19-fauci-reveals-why-us-govt-did-not-advise-people-to-wear-mask.html

[xp38]

When President Trump caught the China Virus he was in and out of hospital quickly and he said his treatment or cure was miraculous. IIRC he didn’t say it was HCQ but was his treatment revealed after?

[bray]

How many Americans died over the DNC hatred of Trump? People should go to jail over this malicious attack.

[Balding_Eagle]

Hehe, it’s been too long since I talked about it!

[BwanaNdege]

While I am grateful for the medical care I have received from the VA, I am VERY disappointed in my Primary Care doctor.

I just sent him this article, asking for a prescription of HCQ AT MY EXPENSE, for prophylaxis and for immediate availability should I develop COVID-19 symptoms while out of the country.

His nurse replied, “Dr. Xxxx declined to write the prescription for Hydroxychloroquine. He suggests you obtain through a locally licensed provider.”

He has been a good doctor for me for many years. However, this is a totally spineless reply. Is this VA policy?

[maddogtiger]

This country is evil. The left (AMA etc) allowed thousands of their fellow citizens to die by suppressing HCQ use. I will never forget this.

[Chgogal]

Funny how this happened.

[Seeing More Clearly Now]

“Fauci means sickle in Italian(Sicilian) Huh?????”

“Fauci” in the Latin precursor of the Italian means “jaws.”

Both the Latin and the Italian derivative meaning do indeed describe the man who was at the center of the funding of virologists’ lab development of this hellish virus and then in 2020, mirabile dictu, the official rules of how hundreds of millions were to deal with it and how not to deal with it.

Who could make up such a scenario and be believed?

[ProtectOurFreedom]

"hacks me off" is gross understatement, RC. It is absolutely infuriating.

Your TexAgs link is also infuriating. Marcus wrote...

"My hospital is questioning monoclonal ab use with dex. So we have to choose and I am reluctant to stop dex."

...and...

"It just feels like for the sick ones who hit the ICU, nothing touches them."

["monoclonal ab" = monoclonal antibodies and "dex" = Dexamethasone, i.e., steroid.]

Over and over again, the key to successful treatment seems to be early and fast treatment at first symptoms at home. Fatality rates really go up once you are in ICU. But even hospitals are questioning the good doctor's request for MAB + Dex. It's infuriating that the hospital administrators (or is it the insurers?) get to second guess the front-line doctor's knowledge and recommendations.

How in the world do you get a doctor who will recommend aggressive outpatient therapy at first symptoms? I asked my doc this and got the brush-off.

[politicianslie]

How in the world do you get a doctor who will recommend aggressive outpatient therapy at first symptoms? I asked my doc this and got the brush-off.

The two doctors here are now prescribing over the phone, and they are NOT alone. There is an over the counter preventative dose listed too.

Dr Tyson and Dr Fareed have treated THOUSANDS with 100% success rate with only a few short hospitalizations

This twitter post is from a couple of months ago. I think he has now treated about 4000 C-19 patients successfully. Compare that to the ER where they test you, send you home to await results WITH NO TREATMENT and then they wonder why people get deathly ill.

Yes the medical professionals are dumb enough to listen to an idiot like Fauci who is responsible for killing tens of thousands of people. I used Dr Fareed when I lost my smell and taste. Like Zelenski said, most patients show significant improvement within 12 hours of starting the Zelenko Protocol.

[ProtectOurFreedom]

Thanks for that link to the Dr Tyson / Dr Fareed protocol. It's interesting that they call for BOTH HCQ and Ivermectin on Day 1. I've been wondering if they might be complementary.

Day 1

HCQ 2 tabs twice a day

Zinc sulfate tab twice a day

(Azithromycin tab one per day or doxycycline cap twice a day)

Ivermectin 12 mg on day 1 only

Aspirin 325 mg

---

I have Ivermectin tablets on hand, but no HCQ on hand. I used a doctor I found at Push Health to prescribe the Ivermectin.

[ProtectOurFreedom]

I found this info about Dr. Fareed at HealthGrades.com:

Dr. George Fareed, MD
Family Medicine, Age 76

Dr. George Fareed, MD is a Family Medicine Specialist in Brawley, CA and has over 51 years of experience in the medical field. He graduated from Harvard Medical School medical school in 1970. He is affiliated with medical facilities El Centro Regional Medical Center and Pioneers Memorial Healthcare District. He has indicated that he accepts telehealth appointments. Be sure to call ahead with Dr. Fareed to book an appointment.

751 W Legion Road
Suite 103a
Brawley, CA 92227

Telehealth services available