THE THERAPEUTIC POTENTIAL OF IVERMECTIN FOR COVID-19: A REVIEW OF MECHANISMS AND EVIDENCE

MedRxIV ^ | 12/04/2020 | Stefanie Kalfas, Kumar Visvanathan, Kim Chan, John Drago

[SeekAndFind]

Abstract

Introduction: Ivermectin is a commonly used antihelminthic agent with over 35 years of established safety data in humans. Recent data demonstrates antiviral activity in vitro against SARS-CoV-2, in addition to a range of viruses. In vitro and animal models also provide evidence of immunomodulatory action.

These additional modes of action are supported by in silico modelling, which propose a number of viral and host targets that would mediate these effects.

Objectives: The aim of this study is to systematically review the published and preprint clinical literature and study results that assessed the potential role of ivermectin as a COVID-19 therapeutic and prophylactic agent.

Methods: We conducted a comprehensive review of PubMed, medRxiv, ClinicalTrials.gov, Global Coronavirus COVID-19 Clinical Trial Tracker, World Health Organization International Clinical Trials Registry Platform, EU Clinical Trials Register, ANZ clinical trials registry, and references from relevant articles.

Results: Search keywords- 'COVID-19 (and synonyms) AND ivermectin'- generated 86 articles on PubMed, 48 on medRvix and 37 on clinicaltrials.gov at the time of writing. Twelve of these were listed as completed clinical trials and of these, 8 were included as investigators had released results.

Positive mortality benefit, reduced time to clinical recovery, reduced incidence of disease progression and decreased duration of hospital admission were reported in patients across all stages of clinical severity.

Limitations: Due to the time-critical nature of the COVID-19 pandemic our review included preprint data, which must be interpreted with caution while it awaits peer review.

Competing Interest Statement: The authors have declared no competing interest.

Funding Statement: No external funding was received

Author Declarations:
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
No IRB/oversight body was required for this systematic review

All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes

Download This PDF File for the full study

[SeekAndFind]

Ping for your interest

[SeekAndFind]

My personal impression:

If the current limited data on ivermectin is confirmed, it is vastly superior to hydroxychloroquine against Covid-19.

[SeekAndFind]

For further evidence,

The analysis of the excellent results of two clinical trials of ivermectin +iota-carrageenan as prophylaxis in Argentina are now published. See the study here:

https://medicalpressopenaccess.com/upload/1605709669_1007.pdf

[sauropod]

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[AFB-XYZ]

What good will it do to have therapeutics, if mandatory vaccines are going to be required in order to have anything resembling a normal life?

That’s mainly a rhetorical question. However, the article earlier today, stating that the CDC will be issuing “vaccination confirmation cards” for those who get the vaccine, does trouble me.

[Bob434]

[[However, the article earlier today, stating that the CDC will be issuing “vaccination confirmation cards”]]

seriously? Do you remember title of the thread?

[Uncle Miltie]

Available at your feed store for horses without a prescription. Just sayin’.

[Polynikes]

“vaccination confirmation cards” for those who get the vaccine,”

Google Contract of Adhesion. If that is superseded then all bets are off.

[AFB-XYZ]

I’ll post the link if I can find it.

[AFB-XYZ]

Bob434 — found it. Here it is:

https://freerepublic.com/focus/f-bloggers/3912270/posts

[Doofer]

Available at your feed store for horses without a prescription. Just sayin’.

Bought some from Amazon a couple weeks ago.

[Bob434]

Thanks- Wow- this is unreal- Very Very close to end times restrictions- I posted in a different thread about the US turning into Nazi Germany- with snitches all around us- turning people in for not exactly complying with covid ‘restrictions’ which aren’t even law-

If these cards go through, it’s gonna be bad- a person will go into a store, not have ‘proof of inoculation’, so they won; be able to purchase anything, and the cops will be called- or the clerk won’t call while customer is in there- but the customer will buy, with credit card of course- which will be flagged, and then the cops alerted- and person gets tracked down later-

Oh Yippie- Where is the world i grew up in? Where we were sovereign citizens with freedoms and protections?

Again- this is eerily close to end times stuff-

[\/\/ayne]

Yes, but can Ivermection be obtained anymore?

[Bob434]

 Yoyo had the same thought abotu what is going on as me i guess in that thread you linked to-

here's the photo they posted in that thread:

[Jane Long]

Ivermectin is available at feed stores and online vet stores.

We keep it stocked in our barn.

[Truthoverpower]

Screw all the complicated expensive guvmint bullcrap

Colloidal silver. Kills em all Free

[Bob434]

supposedly the vetinarian kind can be risky- you’d need a prescription for the the human version, but what are we to tell the docs? “I want ivermectin to prevent Covid”? They usually need a reason to prescribe- not sure if our telling them research is showing promise will be a valid enough reason to get a prescription? I suppose if some folks are on good terms with their docs they could possibly get prescriptions for prevention, but will likely be hard for most everyone else- i would think

[\/\/ayne]

What I have seen is a cream or lotion.

[montag813]

That’s mainly a rhetorical question. However, the article earlier today, stating that the CDC will be issuing “vaccination confirmation cards” for those who get the vaccine, does trouble me.

Wouldn't it be easier to fake a positive COVID PCR test using some kind of documentation? Isn't that valid too so we can participate in Gattaca?