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A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged
elemental ^ | Sept 1, 2020 | Thomas Smith

Posted on 09/08/2020 1:26:22 PM PDT by metmom

A closer look at the Bradykinin hypothesis

arlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.

When Summit was done, researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a “eureka moment.” The computer had revealed a new theory about how Covid-19 impacts the body: the bradykinin hypothesis. The hypothesis provides a model that explains many aspects of Covid-19, including some of its most bizarre symptoms. It also suggests 10-plus potential treatments, many of which are already FDA approved. Jacobson’s group published their results in a paper in the journal eLife in early July.

(Excerpt) Read more at elemental.medium.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: bioweapon; bradykinin; bradykininhypothesis; bradykininstorms; coronavirus; covid; covid19; danieljacobson; helixmakemineadouble; oakridge; summit; supercomputer; tennessee
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To: metmom

Read the other articles.... It slams HCQ and claims that the Kung flu is 5 times more deadly than the flu.... and very deadly and contagious to children.... and so on and so forth.


21 posted on 09/08/2020 2:15:45 PM PDT by Lagmeister
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To: Spirochete

“Jacobson and his team also say that Vitamin D might be helpful in COVID-19 management since it’s involved in the RAS system ...”


22 posted on 09/08/2020 2:16:40 PM PDT by buridan
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To: metmom
Thanks for posting this metmom.

As a vitamin D cheerleader, I found this excerpt very interesting:

I've been taking 5000 iu of vit D every day for many years. Haven't been sick. Have taken no yearly flu shots. Dirt cheap at Wal*Mart or Amazon. Interesting...

Also see: Study shows vitamin D deficiency can increase risk of catching COVID-19
and
Can Vitamin D help combat the coronavirus?
both posted here on FR.

23 posted on 09/08/2020 2:18:40 PM PDT by upchuck (Why are maskers still cussing out non-maskers 6 months later? Shouldn't all non-maskers be dead now?)
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To: metmom
Covid-19 is like a burglar who slips in your unlocked second-floor window and starts to ransack your house.

I knew it, COVID19 is a Member of Congress!!
24 posted on 09/08/2020 2:19:49 PM PDT by eyeamok
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Comment #25 Removed by Moderator

To: aquila48

They are running stranger things now. In 2017 they beat the world champion Go master in S. Korea in a big Asian do...I was sad I did not hear about it. It was about ten years earlier than expected and not using brute force methods. Given the rules of go, the machines played millions of games by themselves and “became” good. Better than us. Go is easy...the win is obvious to us. Rules violations are obvious to us. When they are not, we trust a machine result. I like to think of HAL9000 at this point. What if we NEVER notice?

DK


26 posted on 09/08/2020 2:22:16 PM PDT by Dark Knight
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To: buridan

madness:

VIDEO: 5m13s: 8 Sept: Daily Telegraph Australia: The Australian’s Adam Creighton says there are many vested interests which are benefitting greatly from the COVID hysteria.
Sky News/Alan Jones Show: Guest: Adam Creighton
https://www.dailytelegraph.com.au/news/national/many-vested-interests-are-benefitting-from-the-covid-hysteria/video/745e9f0eb34ff3e7a413fff9ac6703c7


27 posted on 09/08/2020 2:23:36 PM PDT by MAGAthon
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To: Big Red Badger

HAL 9000*: “This mission is too important for me to allow you to jeopardize it.”

*Also, any Never-Trumper, RINO or Socialist Democrat.


28 posted on 09/08/2020 2:23:49 PM PDT by Diana in Wisconsin (I don't have 'hobbies.' I'm developing a robust post-Apocalyptic skill set.)
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To: eyeamok

>>I knew it, COVID19 is a Member of Congress!!<<

Nah. Congress walks straight up to you, looks you in the eye, reaches and grabs your wallet, and empties it.

With laughter.

In broad daylight.


29 posted on 09/08/2020 2:25:45 PM PDT by freedumb2003 ("Do not mistake activity for achievement." - John Wooden)
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To: Boogieman
“You can create a robot that can perform surgery but it will ALWAYS be the team of surgeons and programmers that are actually doing the surgery.”

Do NOT all9w those two jobs to cross over.


30 posted on 09/08/2020 2:28:26 PM PDT by KarlInOhio (In 2016 Obama ended America's 220 year tradition of peaceful transfer of power after an election.)
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To: metmom

“ACE inhibitors — a class of drugs used to treat high blood pressure — have a similar effect on the RAS system as Covid-19, increasing bradykinin levels. In fact, Jacobson and his team note in their paper that “the virus… acts pharmacologically as an ACE inhibitor” — almost directly mirroring the actions of these drugs.”

So does taking ACE inhibitors help fight covid or not? Seems like they should since that’s what the virus first latches on to, but the article is not vet vlear about it.


31 posted on 09/08/2020 2:28:59 PM PDT by aquila48 (Do not let them make you care! Guilting you is how they control you.)
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To: metmom

Fascinating article.


32 posted on 09/08/2020 2:30:25 PM PDT by Lazamataz ("Black Lives Matter" becomes "Terse TV Blackmail"..... #AnagramsNeverLie)
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To: metmom

“Jacobson’s team says in their paper that “the pathology of Covid-19 is likely the result of Bradykinin Storms rather than cytokine storms”

“As bradykinin builds up in the body, it dramatically increases vascular permeability. In short, it makes your blood vessels leaky. This aligns with recent clinical data, which increasingly views Covid-19 primarily as a vascular disease, rather than a respiratory one. But Covid-19 still has a massive effect on the lungs. As blood vessels start to leak due to a bradykinin storm, the researchers say, the lungs can fill with fluid. Immune cells also leak out into the lungs, Jacobson’s team found, causing inflammation.”


33 posted on 09/08/2020 2:30:48 PM PDT by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: Bobalu

RE: No computer can beat a chess master.

IBM’s Deep Blue defeated then, world chess champion, Gary Kasparov in 1997.


34 posted on 09/08/2020 2:33:53 PM PDT by SeekAndFind
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To: metmom

“Interestingly, Jacobson’s team also suggests vitamin D as a potentially useful Covid-19 drug. The vitamin is involved in the RAS system and could prove helpful by reducing levels of another compound, known as REN. Again, this could stop potentially deadly bradykinin storms from forming. The researchers note that vitamin D has already been shown to help those with Covid-19.”

Vitamin D. Cheap insurance.


35 posted on 09/08/2020 2:38:32 PM PDT by Flick Lives (My work's illegal, but at least it's honest. - Capt. Malcolm Reynolds)
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To: Chauncey Gardiner

Apparently I missed that. What’s her name? Do you have a link?


36 posted on 09/08/2020 2:41:01 PM PDT by Veto! (Political Correctness Offends Me)
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To: SeekAndFind

“Defeated GM”
You missed the point which was made by Kasparov at the time.
He congratulated the team’s victory


37 posted on 09/08/2020 2:47:50 PM PDT by BDParrish (God called, He said He'd take you back!)
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To: metmom

New theory: 1. The virus enters through the nose.

You can easily prevent that. Just hold pure copper on the inside of your nose for five seconds. Viruses die. Sounds cockamamie, but it’s true.

A neighbor of mine made me a loop of heavy copper wire. Bought heavy wire at a hardware store and twisted the end into a loop. Cost him $5 max. You can buy similar but smaller products at AMZ for a bit more.


38 posted on 09/08/2020 2:50:35 PM PDT by Veto! (Political Correctness Offends Me)
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To: aquila48; Mom MD

I would not know.

Maybe a medical person would.


39 posted on 09/08/2020 2:56:12 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith.....)
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To: Bobalu

Exactly so.

No computer can beat a chess master.

But a team of chess players who program a computer to play chess can beat a chess master.

The team beat the master...the computer is no smarter than a stone.

AI is a myth, simulated AI is real.

...

AI these days is programmed to self learn, and after a couple of hours of playing against itself, it can beat the best human chess player every time.


40 posted on 09/08/2020 3:00:05 PM PDT by Moonman62 (http://www.freerepublic.com/~moonman62/)
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