Posted on 05/03/2020 7:23:38 AM PDT by SeekAndFind
COVID-19 damages the hemoglobin, impairing the ability of red blood cells to transport oxygen throughout the body, compromising the lungs and resulting in Acute Respiratory Distress Syndrome (ARDS), Italian pharmacology scholar Annalisa Chiusolo explained to The Jerusalem Post.
If her thesis is correct, it would resolve many outstanding questions about the novel coronavirus, such as the greater vulnerability of men – specifically male diabetics – to become seriously ill from the virus, as well as the lower rate at which pregnant women and children contract COVID-19.
Moreover, understanding this mechanism could lead the way to a quicker discovery of the most effective drugs to treat the virus.
Chiusolo is a graduate of the Faculty of Pharmacy of the University of Perugia, Italy, and works as a pharmacist in the European country. Her theory has been published by some of the country’s leading newspapers, including the Italian dailies Il Tempo and Il Giornale.
She told the Post that SARS-CoV-2, the formal name for the novel coronavirus, needs porphyrins for its survival – and probably for its replication – so it attacks hemoglobin, the protein that carries oxygen in the blood, which translates to less oxygen available for the body. The consequence of less oxygen is the accumulation of carbon dioxide.
“The lung cells become the site of the cytokine cascade, an enormous immune response, which is responsible for the acute lung inflammation that characterizes COVID-19 pneumonia,” she said. “The value of hemoglobin in the blood can be an important parameter to assess the SARS-CoV-2 infection: In men the normal value of hemoglobin (Hb) is higher than in women. This would explain the higher incidence of COVID-19 pneumonia in men compared to women, and the lower incidence and better prognosis in children and pregnant women, where Hb values are lower
(Excerpt) Read more at jpost.com ...
It's that simple.
That's why they're standing in the way of early treatment with low-cost therapeutics that have known side effects, if any.
#TheDemocratDealWithXi
Indonesia, with a population of 270 million - more than 2/3 the population of the US, has barely been touched.
That's because they weren't part of the Xi/Democrat plan.
EME doesnt get me anything but cocaine articles
use the ferritin word in her article
btw, this Dr took Trumps drug, HIV drug and Genentech drug. His ferritin level was 18000
https://www.salon.com/2020/04/05/what-it-feels-like-to-survive-covid-19s-dreaded-cytokine-storm/
Also, Medcram easily explains to the layman what this is..it’s vascular.
From the Chinese University paper (current version is 8): “This paper is only for academic discussion, the correctness of the theory needs to be confirmed by other experiments. According to the reader’s suggestion, the content of the drug-related efficacy analysis has been deleted. Due to the side effects of drugs, please consult a qualified doctor for detailed treatment information, and do not take the drug yourself.”
Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
https://www.youtube.com/watch?v=Aj2vB_VITXQ&t=9s
A plumonary DR on the front line at the Texags site said China and Seattle treated this wrong.....probably because it was early stages of figuring out this disease
Ventilators aren’t the answer. He tries to keep them off as long as possible.
I've seen this mentioned many places. A full 30 percent of hospitalizations are male diabetics.
I've paid close attention to this data point over the months because my husband fits that demographic.
wow you remembered that..
that was nice. thank you very much
watch the medcram video I posted. you will get it after you watch it.
FOr those that need CME hours, Medcram did a free webinar on this disease that will get you 1.5 credits. The Dr is on the front line treating patients.
RE: Howard Seth Gold at BIDMC is a Big Pharma quack, and is touting the liver-killing snake oil Remdesivir for its “sovereign cure”
I didn’t know that Remdesivir is a liver-killing drug. Are there any side effects mentioned by Gilead?
There are front line Drs who disagree with you.
Blood oxygen low but Lungs able to easily inflate. Not typically seen in ARDS
I have been watching what front line Drs talk about on the Texags site as they try to figure this disease out and the best way to treat it
since you have a biochemistry back ground let me use broad terms that may somehow link up.
I always look to thalessemia since i have it when new information comes out and see how it ties into malaria..since malaria drugs seem to work with WUhan flu..and thalessemia may have evolved due to malaria
Listen to the biochemistry terms at around the 25 minute mark of the medcram video
https://www.youtube.com/watch?v=Aj2vB_VITXQ&t=9s
You will find MANY articles linking those keywords with thalessemia...like
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC498206/
Increased erythrocyte superoxide dismutase activities in beta 0-thalassaemia/haemoglobin E and in haemoglobin H diseases.
There is a reason malaria drugs MAY provide benefit if given in early stages. People need to figure out why since malaria is due to a parasite.
ONe article I read today said that certain drugs based on artemisinin to combat malaria were not as effective with thalessemia beta patients because of some kind of barrier, etc.
There is a key somewhere with malaria and blood and Covid 19. Someone will eventually figure it out.
...The report published in the New England Journal of Medicine tracked 53 people in the U.S., Europe and Canada who needed respiratory support, with about half receiving mechanical ventilation and four on a heart-lung bypass machine. Eight additional patients were left out of the analysis: one due to a dosing error and seven because no information was available on how they fared.
All received remdesivir for up to 10 days on a compassionate use basis, a program that allows people to use unapproved medicines when no other treatment options are available. Over 18 days, 68 percent of the patients improved, with 17 of the 30 patients on mechanical ventilation being able to get off the breathing device. Almost half of the patients studied were ultimately discharged, while 13 percent died. Mortality was highest among those who were on a ventilator, with 18 percent of them dying....
ANNNNDDDDDD, buried at the bottom of this article:
About one in four patients on the medicine experienced severe side effects, including multiple-organ dysfunction syndrome, septic shock, acute kidney injury and low blood pressure. Another 23 percent showed signs of liver damage on laboratory tests. Four patients had to stop receiving infusions of the drug entirely.
The greatest risk posed to the coronavirus patients treated with remdesivir was liver damage.
Lab work showed enzyme build up in 7.3 percent of the patients. the risk of liver damage became great enough that three percent were removed from the trial.
Your husband is lucky that you have your finger on the pulse...
So now if you think of Italy...besides health care and amount of chinese..why did they have such a problem
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119900/
THe people there that have thalessemia will be mostly the kind that doe not require blood transfusions. btw, Iran has this issue too
Now, when you read this horror article you see many of the buzzwords used in that Medcram video. Keep in mind the lung doctor whose ferritin level was 18000 when it said normal was 400.
Novel Approach to Reactive Oxygen Species in Nontransfusion-Dependent Thalassemia
(After reading this I need to reassess my blood pressure medicine and other things...a lot GPs dont know jack about thalessemia.)
So if you did a similar search with Diabetes ...would you find the same biochemistry $$$$show. Perhaps those with Diabetes should research it.
So knowing thalessemia is possibly related to malaria evolution... scientists need to be looking at how people with thalessemia deal with this..and how effective malaria drugs are with it.
That horror article I linked are the kinds of issues people with Covid-19 are dealing with.
It was developed in the 1940s and they're pretending there are NEW problems they're discovering?
So, if there are serious side effects, stop the HCQ. Then use... What?
Their rebuttal is, and has been from the beginning, that there is only anecdotal evidence in regards to hydroxychloroquine and “studies” (see research grants) need to be done - there may be an answer in a few years. Meanwhile, mostly failed early evidence on new (read EXPENSIVE) treatments are getting very positive press.
Any positive news is trashed by the left if it makes POTUS Trump look good. Any vaccine or remedy has to be leftist approved. Sick world we live in.
“Tonic Water” - you need 3 liters every single day to get a moderate dose. Enjoy!
And if “Orange Man Bad” should fail for any reason, there’s always the time-tested fallback “Racist!!” Just like Whitmer rolled out today in Michigan.
RE: So, if there are serious side effects, stop the HCQ. Then use... What?
The other FDA sanctioned drug — Remdesivir, which has to be given intravenously is the other option. NOT CHEAP. I’m sure there are other side effects with Remdesivir as well.
Heck, what drug doesn’t have side effects given certain patient conditions and the dosage administered?
Arrythmia is ALREADY a well known side effects for patients with certain conditions. Even Dr. Zelenko and other who use Hydroxychloroquine know this and have said so. It’s not some “new” discovery.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.