Italian scientist says she discovered main mechanism behind COVID-19: Annalisa Chiusolo shows how controversial drug Hydroxychloroquine could make people immune to virus

Jerusalem Post ^ | 05/03/2020 | By MAAYAN JAFFE-HOFFMAN

[SeekAndFind]

COVID-19 damages the hemoglobin, impairing the ability of red blood cells to transport oxygen throughout the body, compromising the lungs and resulting in Acute Respiratory Distress Syndrome (ARDS), Italian pharmacology scholar Annalisa Chiusolo explained to The Jerusalem Post.

If her thesis is correct, it would resolve many outstanding questions about the novel coronavirus, such as the greater vulnerability of men – specifically male diabetics – to become seriously ill from the virus, as well as the lower rate at which pregnant women and children contract COVID-19.

Moreover, understanding this mechanism could lead the way to a quicker discovery of the most effective drugs to treat the virus.

Chiusolo is a graduate of the Faculty of Pharmacy of the University of Perugia, Italy, and works as a pharmacist in the European country. Her theory has been published by some of the country’s leading newspapers, including the Italian dailies Il Tempo and Il Giornale.

She told the Post that SARS-CoV-2, the formal name for the novel coronavirus, needs porphyrins for its survival – and probably for its replication – so it attacks hemoglobin, the protein that carries oxygen in the blood, which translates to less oxygen available for the body. The consequence of less oxygen is the accumulation of carbon dioxide.

“The lung cells become the site of the cytokine cascade, an enormous immune response, which is responsible for the acute lung inflammation that characterizes COVID-19 pneumonia,” she said. “The value of hemoglobin in the blood can be an important parameter to assess the SARS-CoV-2 infection: In men the normal value of hemoglobin (Hb) is higher than in women. This would explain the higher incidence of COVID-19 pneumonia in men compared to women, and the lower incidence and better prognosis in children and pregnant women, where Hb values are lower

[xkaydet65]

Easy rebuttal DP...Orange man bad.

[RummyChick]

Well since she is from Italy maybe we can finally get someone to look at how hemoglobin disorders that are thought to have evolved from malaria deal with Covid 19..such as Thalessemia -seen in Italians..and Sickle cell seen in Africans

[newzjunkey]

That means there might be results in November. That’s just in time for the presumed next wave of the virus

[RummyChick]

when you put

ecgonine methyl ester

into a search engine a lot of Cocaine articles pop up

[null and void]

It took over 100 year to figure out how aspirin works...

Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

The false positive rate was 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

If a quarantine saves just one child's or one old fart’s life, it's worth it.

[aquila48]

Bookmark

[RummyChick]

I have seen some people talk about taking artemisinin because it has been known to help with malaria

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048293/

HOWEVER, if you are in the group that have hemoglobin disorders...here is an interesting blurb (usIng one of the buzzwords by the Italian Dr in a search) . this might apply to people with sickle cell trait, too

https://www.memoireonline.com/09/07/603/m_interaction-quinolines-artemisinin-antimalarials-drugs-with-ferriprotoporphyrin6.html

There is currently no evidence for clinically relevant artemisinin resistance (Meshnick, 2002), but Kamchonwongpaison and co-workers have reported that P. falciparum parasites in - thalassemic red cells are more resistant to artemisinin and artesunate than parasites in genetically normal cell (Kamchonwongpaison et al., 1994). Because P. falciparum infected thalassemic red cells have a decreased capacity to accumulate drug. In fact, the thalassemics are a group of genetic diseases with defects in globin chain synthesis in -thalassemic, there is decrease in -globin chain whereas in -thalassemia, there is a decrease in -globin synthesis. This result suggests that special precaution should be made for using artemisinin compounds in the treatment of malaria in any area where abnormal globin-gene frequency is high since this will facilitate the development of artemisinin resistance. Paradoxically, thalassemia appears to confer resistance to malaria infection in vitro and in vivo (Weatherall, 1987; Yuthavong and Wilairat, 1993).

[dp0622]

great. now i’m back to square one :)

[17th Miss Regt]

Oh, don’t forget to mention to dp0622 - “You’re a racist!”

[kiryandil]

“The accumulating evidence is that there is limited data to suggest efficacy and there’s growing evidence that suggests toxicity,” Dr. Howard Gold, infectious disease doctor at BIDMC, said of the drug hydroxychloroquine in an interview published by the Boston Herald.

Sounds like this quack Gold is in Big Pharma's pocket - or he's in their wallet.

[dp0622]

It’s easy arguing on the left.

It boils down to one man.

Saves a lot of debate time.

[LibertarianLiz]

Wow, even the Jerusalem Post is calling this drug “controversial”. Sigh.

[RummyChick]

Not exactly.

I FINALLY found something that might apply to COVID 19, Italians, and Trump's miracle drug..thanks to this article So you should keep this link if your family members who have thalessemia get Wuhan Flu.

https://www.semanticscholar.org/paper/Pharmacologic-interception-of-heme%3A-a-potential-for-Scott-Yang/82b2af48b3a4c9a1ff0312227d2ba72456609c41

Pharmacologic interception of heme: a potential therapeutic strategy for the treatment of β thalassemia?

btw, Medcram uses a lot of the buzzwords in the above article as it relates to Covid 19 and the oxidative stress issue.

If I get the symptoms of Wuhan flu (my neighbor has it) I am going to hit a DR up immediately for Trump's drug with this article and other info I have and let them figure out the relevance of this article as I am not a biochemist! They might tell me this article explains why I shouldnt take Trumps drug

have to go do more research as this is an old study

[yldstrk]

Of course in the USA the only legitimate thing is something expensive and new that the elites can profit from.

[Aevery_Freeman]

Yep. Remdesivir by Gilead is expensive a.k.a. profitable.

Gates wants us all "chipped".

They don't even bother being covert anymore.

[RummyChick]

btw, one of the lung doctors who almost had to be put on a ventilator had astronomical ferritin levels.

IIRC, he used Trump’s drug and some other things. The article was from Slate.

[logi_cal869]

“The lung cells become the site of the cytokine cascade, an enormous immune response, which is responsible for the acute lung inflammation that characterizes COVID-19 pneumonia,”

---

Someday these dumbasses suffering from myopia will see the forest through the trees and realize that ground zero for the battle against SARS-CoV-2 is the lungs.

Hemoglobin effects & consequent organ damage are results of a major blood infection akin to sepsis. Early treatment in vulnerable patients would inhibit such complications, perhaps prevent them altogether (as in the cases of me & my wife).

SMH

[Valpal1]

Everyone on this thread glosses over the article quoting a different doctor counter that this action should result in anemia which is easily tested for and it’s not showing up.

That’s the problem with this theory and it doesn’t explain the micro blood clots in organs.

There is more going on.

[kiryandil]

Yep, a little investigation shows that it's almost certain that Howard Seth Gold at BIDMC is a Big Pharma quack, and is touting the liver-killing snake oil Remdesivir for its "sovereign cure" for light wallets in the "healthcare" industry:

BIDMC [Beth Israel Deaconess Medical Center] enrolling patients in clinical trials evaluating existing drug as treatment for severe COVID-19
April 10, 2020
https://www.newswise.com/coronavirus/bidmc-enrolling-patients-in-clinical-trials-evaluating-existing-drug-as-treatment-for-severe-covid-19/?article_id=729763

Sarilumab [developed by Regeneron and Sanofi]
Other projects include research into a potential vaccine for the prevention of COVID-19, clinical trials to evaluate the antiviral medication remdesivir, and efforts to source and produce critical medical supplies and equipment...

“The accumulating evidence is that there is limited data to suggest efficacy and there’s growing evidence that suggests toxicity,” Dr. Howard Gold, infectious disease doctor and Remdesivir shill at BIDMC, said of the drug hydroxychloroquine in an interview published by the Boston Herald, just before the article pivoted to shilling for liver-killing Remdesivir...

[corkoman]

I searched for ecgonine methyl ester AND malaria and got nothing.

This "linking" HCQ mechanism with hemoglobin is kinda thin. Real thin. Ill go deeper into biochemistry journals