Posted on 04/30/2020 3:05:32 PM PDT by RaceBannon
Corona Virus Daily Thread #49 COVID-19 4/30/2020
After reading some scientific articles of which I do not understand...it seems Medcram and Texags Dr are on the right track of this being a vascular issue.
My brother read this molecular article on cancer and said so....is low LDH good or bad when it comes to Cancer and Covid.
I said, hell if I know...Science is hard. ...lol
btw, this Dr is getting them late in the development of the disease. i think he is a lung dr. :
Marcus AureliusIn reply to Aggie95 • 6:30pAG
Yes. I would be more comfortable with more widespread re-opening knowing there was at least one effective drug. As far as mortality effects. Unfortunately has not been proven yet. But those studies are pending. Tocilizumab will prove to reduce mortality I am certain. Hopeful HCQ / ARB trials will prove some benefits.
Exclusive — Amazon Warehouse Whistleblower Fired by Bezos: Management ‘Told Me not to Tell the Employees’ of a Coronavirus outbreak
Marcus Aurelius said:
Not understood completely. But 2 modes of transmission. Aerosolization of respiratory droplets and touching surfaces with viral particles then touching your face. I’ve read articles touting both methods as being superior in transmission. IMO sustained intimate contact over 20 minutes with an infected individual is highest risk. Getting infected from a keypad while paying for your groceries much less likely. If everyone wears masks transmission rates drop 90%.
Marcus AureliusIn reply to normaleagle05 • 4:43p, 4/30/20AG
I read about it earlier in the month. I can’t find the link now sorry. That is based off the NIH Japan study of asymptomatic transmission. The large reduction in transmission by using surgical or cloth masks is theorized in asymptomatic patients. Studies have been done in smaller groups of symptomatic patients with coronavirus and influenza and have shown a much lower although improved reduction in transmission. This is why the CDC changed their recommendation recently for all to wear surgical or cloth masks in public indoor places when feasible. One would hope/assume that symptomatic people are not out in public, even with masks on.
https://www.nature.com/articles/s41591-020-0843-2
No material on this site is intended to be a substitute for professional
Respirators certainly dont seem to be effective, therefore the problem is not just lung related.
Remember this guy?
amzn dropped almost 8 percent today after earnings
i cant stand bezos but amazon does give me good customer service and promptly refunds money if there is an issue and lets you keep the product...of course I am talking low dollar items..less than 10 bucks
Amazon is very convenient.
I just can’t stand bezos either. wonky eyed mfer.
I’ll spend a buck or two extra if I can get something somewhere else unless I need a bunch of something.
Dr Louis P Coates
21 hrs ·
Coronavirus Update 5/01/2020 - BTHO COVID-19
So today at the time of this writing there are 30,825 new cases today with 2,201 deaths. Cases are relatively steady today but are still relatively flat. But deaths are declining. Today the mortality rate is down from 8.43% to 7.14%. We also have 15,226 so dropped some luckily but it is still high so the fatality numbers will likely stay high a while longer.
So this also rose the overall mortality rate to 5.83%. A bad day all around on the death front.
We also have now had 152,325 people recovered from this virus and should now be considered immune from this horrific disease.
Locally, in Texas we are still plateaued and we are starting on the downside of the curb. We had 1289 new cases and 51 new deaths with a steady mortality rate of 2.8%.
The antibody testing is starting to be added to the numbers. So we have 14,516 up from 13,728 active cases in Texas. In addition we have 13,353 recovered today.
Today in Dallas county 179 new cases and 5 new deaths. Harris county with 195 new cases and 5 new deaths. Collin county with 18 new cases and no new deaths. Denton county with 10 new cases and no new deaths. Tarrant county with 158 new cases and 10 new deaths. Brazos county with 5 new cases and no new deaths. Travis county with 115 new cases and 5 new deaths.
For the newbies we are predicting an overall fatality rate somewhere in the 0.3 to 0.7 range when we finally correct the denominator. The real question is just how much of the population is already infected 2%, 5%, 10% etc.
Since I confused everyone let’s try again in a more simplistic manner
Ok Let’s see if I can explain the angiotensin pathway a little easier to understand. So let’s look at the pathway diagram again and let’s assume you have 3 roads in which you can use to drive to work. So the first road is an old beat up asphalt road with huge potholes (think free radicals) 6 inches deep in it. That road is called AT1R. When you drive on it you can feel it beating up your car.
The next road is a smooth 3 line street and is in good condition. You drive to and from work with no problems. This road is called AT2R. The final road is a new smooth freeway called Angiotensin 1-7.
So depending on which road you choose you will have more wear and tear on your daily car lets say a lexus (middle age adult). Think of the car like the endothelium. The more you drive on AT1R the more damage is getting done to the tires, the breaks, the suspension etc. If you take this road too often or you are unlucky at hit a pothole just right you could do some damage to the car even on one trip. If you take the AT2R it is stop and go a lot on the way. So better but still wearing down the tires and breaks a little. Finally, Ang 1-7 does very little damage at all to the car and it can last a long time.
Now let’s say you get an elevated pickup truck with big tires and 4 wheel drive. (This is children and young adults). They choose any road and not have any trouble at all. They can just take whichever road they want without worrying about any risks.
Now let’s say you bought a new Ferrari sitting 4 inches off the ground. (This is the eldery, diabetics, heart disease, & obese patients) You take this car on the AT!R and it will likely destroy the first trip even if you try to be very careful. So this is a crude example of why the diabetics, obese and heart patients are getting so sick. They are in a delicate car and the other two roads are essentially getting closed down by the virus.
Now let’s go back to the ARB’s. They are essentially putting up a roadblock where the green X is forcing all of the traffic back onto the good roads thus preventing the damage to the vehicle.
ACE inhibitors block the road earlier at the (blue) ACE and push all the traffic to Ang (1-7) the freeway. So both of these drugs could potentially help.
Now N-acetylcysteine (NAC) is an antioxidant so while it does no block any of the roads it still helps. It works by essentially fixing some of the holes in the road to help prevent damage to vehicles. Since it is an antioxidant it removes these free radicals which is damaging the endothelium.
Hopefully this is easier to understand!!!
Here is a repost of the supplements we have discussed.
Zinc any amount is probably good but take what you can tolerate without making you feel bad up to 40mg. You do not want to be Zinc deficient as it is how many drugs like HCQ work.
Quercetin from 250mg up to 1g twice per day Remember this is a Zinc ionophore.
Green Tea either drink some or 1 pill per day alternate zinc ionophore
N-acetylcysteine (NAC) - 600mg twice per day shown to decrease severity of influenza, improve lung functions and help with mental disorders.
Melatonin 1mg to 10mg at night. Take what you can tolerate and what helps you sleep without making you feel drugged or tired in the morning.
Vitamin C 250mg to 500mg twice per day. Effects debatable in oral form but IV did help in China. But is proven to strengthen immune system
Vitamin D3 Take this for sure if you are deficient and I now recommend taking it as long as your values are not too high.
Sleep greater than 8 hours per night
As always the information and understanding of COVID-19 is changing rapidly. This information is for education purposes only and you should never make changes to your health without consulting your personal physician. Make a virtual appointment with your physician and discuss your health and the best possible treatment plan for you. It is also important to reiterate that there are no clinically evidence-based integrative prevention or treatment strategies for COVID-19 infection.
Let’s all keep praying for all that are ill with this virus in the world.
Gig’em!
Sounds like some of the FBs around here
https://www.nejm.org/doi/full/10.1056/NEJMoa2008975?query=featured_coronavirus
Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
https://www.nejm.org/doi/full/10.1056/NEJMoa2006923?query=featured_home
Yes, plus they were trimmer and healthier before that.
Interesting that the UK wanted to go that route until it was too politically unpopular—and they had to change course.
I am very disappointed that we haven’t dug in on options to help grandparents living with school children, etc., to give protective options there. I am not quite sure how they would do that. Maybe those kids don’t go back to school yet? And for young adult workers with, say, older, compromised family members? To me this is the issue we don’t have handled. But get that under control and we can open up more sooner.
Also, I really think we need to crank up HCQ production and availability, despite Fauci’s protestastions, too. Those on the front lines ought to have it as an option early or even prophylactically.
All that started the same time the billionaires decided the peasants had to work.
That’s when the flu bros showed up and the astro turfing began.
I would put the dodgy antibody tests in there too (you’ve all had it, get back to work!)
The timing is suspicious indeed. I find it interesting that the narrative started out as being we were part of some conspiracy to hurt Trump by following cv news, but when he started supporting shutdowns, they turned on him in a heartbeat.
From The Guardian...
“Scientists working for the US military have designed a new Covid-19 test that could potentially identify carriers before they become infectious and spread the disease, the Guardian has learned. “
That’d be great.
From The Guardian...
“Scientists working for the US military have designed a new Covid-19 test that could potentially identify carriers before they become infectious and spread the disease, the Guardian has learned. “
That’d be great.
from a layman’s perspective
If high Ldh is a biomarker for many kinds of cancer and inflammatory issues
with many articles using the same buzzwords that Medcram is using in talking about COVID and the vascular issue
shouldn’t someone be looking at whether massive doses of Vitamin C..which is known to reduce LDH...might be a benefit directly linking to LDH/ COVID...or for that matter..Cancer.
my ldh is so low 70 that I had to think back to the last time I took liposomal C. I have not been retested but pretty sure enough time had gone by that the liposomal C did not effect it. I usually cut off all supplements at least two weeks before a blood test.
Just a thought for future studies
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