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Dr Louis P Coates
21 hrs ·
Coronavirus Update 5/01/2020 - BTHO COVID-19

So today at the time of this writing there are 30,825 new cases today with 2,201 deaths. Cases are relatively steady today but are still relatively flat. But deaths are declining. Today the mortality rate is down from 8.43% to 7.14%. We also have 15,226 so dropped some luckily but it is still high so the fatality numbers will likely stay high a while longer.

So this also rose the overall mortality rate to 5.83%. A bad day all around on the death front.

We also have now had 152,325 people recovered from this virus and should now be considered immune from this horrific disease.

Locally, in Texas we are still plateaued and we are starting on the downside of the curb. We had 1289 new cases and 51 new deaths with a steady mortality rate of 2.8%.

The antibody testing is starting to be added to the numbers. So we have 14,516 up from 13,728 active cases in Texas. In addition we have 13,353 recovered today.

Today in Dallas county 179 new cases and 5 new deaths. Harris county with 195 new cases and 5 new deaths. Collin county with 18 new cases and no new deaths. Denton county with 10 new cases and no new deaths. Tarrant county with 158 new cases and 10 new deaths. Brazos county with 5 new cases and no new deaths. Travis county with 115 new cases and 5 new deaths.

For the newbies we are predicting an overall fatality rate somewhere in the 0.3 to 0.7 range when we finally correct the denominator. The real question is just how much of the population is already infected 2%, 5%, 10% etc.
Since I confused everyone let’s try again in a more simplistic manner

Ok Let’s see if I can explain the angiotensin pathway a little easier to understand. So let’s look at the pathway diagram again and let’s assume you have 3 roads in which you can use to drive to work. So the first road is an old beat up asphalt road with huge potholes (think free radicals) 6 inches deep in it. That road is called AT1R. When you drive on it you can feel it beating up your car.

The next road is a smooth 3 line street and is in good condition. You drive to and from work with no problems. This road is called AT2R. The final road is a new smooth freeway called Angiotensin 1-7.

So depending on which road you choose you will have more wear and tear on your daily car lets say a lexus (middle age adult). Think of the car like the endothelium. The more you drive on AT1R the more damage is getting done to the tires, the breaks, the suspension etc. If you take this road too often or you are unlucky at hit a pothole just right you could do some damage to the car even on one trip. If you take the AT2R it is stop and go a lot on the way. So better but still wearing down the tires and breaks a little. Finally, Ang 1-7 does very little damage at all to the car and it can last a long time.

Now let’s say you get an elevated pickup truck with big tires and 4 wheel drive. (This is children and young adults). They choose any road and not have any trouble at all. They can just take whichever road they want without worrying about any risks.

Now let’s say you bought a new Ferrari sitting 4 inches off the ground. (This is the eldery, diabetics, heart disease, & obese patients) You take this car on the AT!R and it will likely destroy the first trip even if you try to be very careful. So this is a crude example of why the diabetics, obese and heart patients are getting so sick. They are in a delicate car and the other two roads are essentially getting closed down by the virus.

Now let’s go back to the ARB’s. They are essentially putting up a roadblock where the green X is forcing all of the traffic back onto the good roads thus preventing the damage to the vehicle.

ACE inhibitors block the road earlier at the (blue) ACE and push all the traffic to Ang (1-7) the freeway. So both of these drugs could potentially help.

Now N-acetylcysteine (NAC) is an antioxidant so while it does no block any of the roads it still helps. It works by essentially fixing some of the holes in the road to help prevent damage to vehicles. Since it is an antioxidant it removes these free radicals which is damaging the endothelium.

Hopefully this is easier to understand!!!

Here is a repost of the supplements we have discussed.

Zinc any amount is probably good but take what you can tolerate without making you feel bad up to 40mg. You do not want to be Zinc deficient as it is how many drugs like HCQ work.
Quercetin from 250mg up to 1g twice per day Remember this is a Zinc ionophore.
Green Tea either drink some or 1 pill per day alternate zinc ionophore
N-acetylcysteine (NAC) - 600mg twice per day shown to decrease severity of influenza, improve lung functions and help with mental disorders.
Melatonin 1mg to 10mg at night. Take what you can tolerate and what helps you sleep without making you feel drugged or tired in the morning.
Vitamin C 250mg to 500mg twice per day. Effects debatable in oral form but IV did help in China. But is proven to strengthen immune system
Vitamin D3 Take this for sure if you are deficient and I now recommend taking it as long as your values are not too high.
Sleep greater than 8 hours per night

As always the information and understanding of COVID-19 is changing rapidly. This information is for education purposes only and you should never make changes to your health without consulting your personal physician. Make a virtual appointment with your physician and discuss your health and the best possible treatment plan for you. It is also important to reiterate that there are no clinically evidence-based integrative prevention or treatment strategies for COVID-19 infection.

Let’s all keep praying for all that are ill with this virus in the world.

Gig’em!