Posted on 04/21/2020 4:53:48 AM PDT by RaceBannon
new thread, starting 4/21/2020
DATA, DATA and more DATA
A 25 March paper in JAMA Cardiology documented heart damage in nearly 20% of patients... In another Wuhan study, 44% of 36 patients admitted to the ICU had arrhythmias...
The disruption seems to extend to the blood itself. Among 184 COVID-19 patients in a Dutch ICU, 38% had blood that clotted abnormally, and almost one-third already had clots, according to a 10 April paper in Thrombosis Research...
Mangalmurti says she has been “shocked by the fact that we don’t have a huge number of asthmatics” or patients with other respiratory diseases in HUP’s ICU. “It’s very striking to us that risk factors seem to be vascular: diabetes, obesity, age, hypertension.”...
...Viral particles were identified in electron micrographs of kidneys... But kidney injury may also be collateral damage. Ventilators boost the risk of kidney damage, as do antiviral compounds including remdesivir...
..Frontera has seen patients with the brain inflammation encephalitis, with seizures, and with a “sympathetic storm,” a hyperreaction of the sympathetic nervous system that causes seizurelike symptoms and is most common after a traumatic brain injury. Some people with COVID-19 briefly lose consciousness. Others have strokes. Many report losing their sense of smell. And Frontera and others wonder whether in some cases, infection depresses the brain stem reflex that senses oxygen starvation...
ACE2 receptors are present in the neural cortex and brain stem, says Robert Stevens, an intensive care physician at Johns Hopkins Medicine. But it’s not known under what circumstances the virus penetrates.... On 3 April, a case study in the International Journal of Infectious Diseases, from a team in Japan, reported traces of new coronavirus in the cerebrospinal fluid of a COVID-19 patient who developed meningitis and encephalitis...
longer read
More:
Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study
…”Using a loess regression analysis, we found that in the mild group, the viral load in respiratory samples was greater during the initial stages of the disease, reached a peak in the second week from disease onset, and was followed by lower loads (fig 3). In the severe group, however, the viral load in respiratory samples continued to be high during the third and fourth weeks after disease onset (fig 3). The viral load of stool samples was highest during the third and fourth weeks after disease onset (fig 3).”
21 April
https://www.bmj.com/content/369/bmj.m1443
Study Raises Questions About False Negatives From Quick COVID-19 Test
The ID NOW has generated widespread excitement because it can produce results in less than 15 minutes.
...Abbott said any problems with the test could stem from samples being stored in a special solution known as viral transport media before being tested, instead of being inserted directly into the ID NOW testing machine. As a result, the company recently instructed all users to only test samples put directly into the machines.
Based on his study, Procop said his hospital has stopped using the test to screen patients being admitted for care. The hospital also stopped using another test, called the DiaSorin Simplexa, because it only detected 89.3% …
...the test developed by the Centers for Disease Control and Prevention, which detected 100% of positive samples. Another test, made by Roche, detected 96.5% of positive samples. The fifth test in the study, made by Cepheid, detected 98.2% of infected samples, Procop said. The Cepheid test produces results in less than an hour.
WLRN - Miami
https://www.wlrn.org/post/study-raises-questions-about-false-negatives-quick-covid-19-test
MedCram Lecture
Dr. Roger Seheult
April 21, 2020
Coronavirus Pandemic Update 59: Dr. Seheult’s Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
We recorded this video in response to your comments asking what Dr. Seheult’s daily regimen is - to optimize his immune system and minimize COVID-19 risk. In the absence of good clinical data that is specific to SARS-CoV-2, Dr. Seheult discusses supplements, sleep, and his daily disinfection routine when removing PPE, getting in his car, and returning home from the hospital. We look forward to more randomized, blinded, placebo-control studies in the future that will build upon the current body of evidence as it relates to immunity and specifically coronaviruses such as SARS-CoV-2.
https://www.youtube.com/watch?v=NM2A2xNLWR4
MedCram Lecture
Dr. Roger Seheult
April 20
Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion)
Two recent antibody testing studies in the United States may give insight into how widespread COVID-19 actually is - which may also mean the fatality rate is lower than initially thought - but there may be problems with the accuracy of using this data in a prediction model. Dr. Seheult also illustrates the key differences between different types of hypoxemia (low blood oxygen): V/Q mismatch, shunting, and diffusion abnormalities. COVID-19 infection may involve all three of these to varying degrees and MIGET (multiple inert gas elimination technique) studies may unlock some of the mystery.
https://www.youtube.com/watch?v=nO4xgcIaPeA
You want to get the liquid
“Cramer says, ‘We’ve got to try something’ as Georgia, other states begin to reopen’
I wonder if there is graph like that for the USA. That really puts a dent in the Flu argument.
I just got thinking maybe the USA should be divided into regions. The peak is different depending on where you live. I think California might take off in number of new cases.
California started with the weaker strain, could the deadlier strain (New York) just now arrived in California?
This all depends on if a person is not resisted to the other strain if they had one strain already or the antibodies effect don’t last that long.
“California reports highest one-day rise in coronavirus cases”
California just might explode with new cases...
Wow, and to make matters worse, the people moving the bodies don’t have the appropriate PPE
And yesterday was our highest total daily death at 2,804. It appears there’s always a dip on Monday (probably because of Sunday), but they’ll write a news story every time
This is interesting. Our GA Governor had a presser yesterday (or maybe the day before) where he was saying we had to open back up because people were dying of heart attacks caused by stress.
My first thought was, could these be heart attacks caused by CV? I hope they are testing. We have a lot of 50-somethings dropping of heart attacks and seizures in my county, this is NOT normal. We had 25 new cases of CV yesterday (our biggest jump).
https://www.thenewatlantis.com/publications/not-like-the-flu-not-like-car-crashes-not-like
Fungi...that sounds like secondary infections caused by *another* particular virus...
Fungal infections are common enough and one of the causes of the general category of symptoms labeled as pneumonia.
Fungal infections are opportunistic infections.
People with weakened immune function, in particular, succumb to those.
So a virus that takes out your immune system puts you at risk for fungal infections.
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