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Leading Epidemiologist 'Absolutely Confident' Antiviral Drugs Will Stem COVID-19 Pandemic
WBUR ^ | March 27, 2020 | Jeremy Hobson

Posted on 03/29/2020 12:30:08 AM PDT by nickcarraway

Dr. Larry Brilliant has been on the frontlines in the fight against disease for decades.

The epidemiologist helped eradicate smallpox, and he's also been involved in the battle against polio and blindness. In a 2006 TED Talk, Brilliant described what the pandemic would look like — and he says the coronavirus pandemic has the potential to infect more people than he predicted.

“I think it has the potential for infecting more than a billion people,” he says. “I'm optimistic that for this particular virus, which has a relatively low death rate compared to smallpox and others, that the death rate would be less than that. But as far as its disruption, yes. It's every bit as disruptive as I feared.”

While a vaccine for COVID-19 could take more than a year to develop, Brilliant says he is optimistic that scientists will be able to reduce the virus’s toll with antiviral medications.

Get breaking news alerts and updates about the coronavirus outbreak across New England in your inbox. Sign up now.

“I'm absolutely confident that we will have an antiviral that works, but it'll take us a little while to know which ones work and which ones don't work,” he says. “I talk always about a vaccine, but it is possible and I'm optimistic that we will find an antiviral that not only is curative but is also preventative.”

Brilliant, who worked on the film “Contagion” as senior technical adviser, says the current pandemic won’t be as horrific as the one portrayed in the film.

“The fictional virus that we created in the movie ‘Contagion’ is far worse than [COVID-19],” he says. “We made that movie in order to kind of refute the sentiment in the country after the swine flu of 2008-2009, where people thought, 'Ho hum, if that's what a pandemic is, I'm not worried.' We wanted to kind of rejigger people's sentiments, so they understood what a real pandemic would look like.”

Interview Highlights On how antiviral drugs could cure and prevent COVID-19

“We have one now for HIV/AIDS, and we know that Tamiflu would stop an outbreak of certain influenzas. So we know that antivirals can be used as surrogate or pseudo vaccines. It'll be a lot easier to manufacture billions of doses of an antiviral. I'm hoping that we find an antiviral that is not only curative but is preventative. I'm confident of the former. In the next four months, I'm hopeful of the latter.”

On what the federal government should be doing right now

“We've had such a failure of leadership from the federal government. We should be demanding, I guess, that states and counties have plans for the next two years, their own plans. We should have a Manhattan Project for antiviral drugs, a moonshot for [a] vaccine and ventilators, and especially a real thoughtful plan on when we are going to clamp down with social isolation, quarantine. We don't have any of those things. And really, that's what we've always had in the past from the federal government. And I have to tell you, I miss it.

“I don't think it's going to go on with the intensity that it will go on in the next four months. But certainly, it's going to have a long tail. By the way, I just read that nine out of 10 Americans today are doing something to self isolate, to wash their hands. That's something we can be very proud of. And that's to flatten the curve. But when we flatten the curve, we don't reduce the number of cases of the epidemic in its lifetime. But by pacing it, we reduce the number of deaths because we can care for each case better, and we also reduce the number of deaths from heart attacks and trauma and all the other things that we usually take care of all the time. Yes, I think we need a plan for a couple of years. There'll be a very big difference in 12 to 18 months when we have a vaccine. Then it will be a question of vaccinating everybody as quickly as possible and then mopping up all the hotspots in the world with a measles, smallpox, polio type of almost eradication program.

“I urged President Trump to announce three moonshots: one to get antivirals quicker, two, to get respirators and ventilators made cheaper in the United States right now, and three, to work on test kits and to get so many test kits that they're so cheap, they're done at home like home pregnancy tests. If we do this with the power of the federal government, we create a buying consortium so that industry has a price signal that makes them put in the effort to do a Manhattan Project or a moonshot. These three, they would be able to really stem the tide of this epidemic.”

On the argument that the cure could be worse than the disease because of the economic impact

“I understand where that comes from. I mean, it's so hard to think about the empty streets of San Francisco. You watch the stock market and people are unemployed. Three million people applying for [unemployment]. I understand where that comes from. Unfortunately, it isn't our choice. The virus leads us and ... much like a patient who's sick, taking our medicine now will prevent half of the deaths that we expect otherwise. I mean, if you look at what [University of Washington health statistician Chris Murray] said, 85,000 people dying in the next four months. And if you take a look at the models that are coming out of the Imperial College in England, it suggests that it could be as many as to [2 million], [2 and a half million] Americans who die during the course of this disease. If we practice strong isolation techniques, all the things we know we must do, we'll reduce the number of deaths by at least half. That's a huge number of people to trade off for a short burst of quarantine-like effects. The economy is terribly important, but people are first.”


TOPICS: Health/Medicine; Science
KEYWORDS: coronavirus; drugs; hydroxychloroquine; medication
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To: cuban leaf

Notice that number you’re talking about is for Sunday March 29th. We are only a few hours into that day, so that’s only a partial number. It would be great if that was all.


21 posted on 03/29/2020 2:57:18 AM PDT by nickcarraway
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To: BookmanTheJanitor

YOU MUST, MUST SEE THIS:

EXCELLENT NEWS: Hydroxychloroquine Treatment Effective on 699 Patients

https://www.youtube.com/watch?v=1TJdjhd_XG8&t=586s


22 posted on 03/29/2020 3:00:14 AM PDT by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
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To: nickcarraway

I’m not sure who he is, but he’s quoting reports that have been refuted - by the author. That’s a big deal because that report created quite a frenzy. (Imperial college)


23 posted on 03/29/2020 3:00:43 AM PDT by HollyB
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To: dp0622

Just another Trump hater who makes it to this board.>

A dirty bastard.

BUT YOU MUST SEE THIS ( The President fights back using Rudi Giuliani)

EXCELLENT NEWS: Hydroxychloroquine Treatment Effective on 699 Patients

https://www.youtube.com/watch?v=1TJdjhd_XG8&t=586s


24 posted on 03/29/2020 3:03:23 AM PDT by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
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To: Candor7

Rudy seems pretty sharp. Sharper than he has sounded in past years. I am glad. I wonder why the antibiotic helps also.

Maybe because some of the pneumonia that develops is bacterial?

I’d rather have Rudy at 40% then de Blasio at 110%. God I can’t stand him.

There will always be a place in my heart for New York City but when the city elects a man that is married to a lesbian it’s over.


25 posted on 03/29/2020 3:10:50 AM PDT by dp0622 (Radicals, racists dont point fingers at me I'm a small town white boy Just tryin to make ends meet)
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To: dp0622

a man that is married to a lesbian it’s over.>>>>>>

The only reason for that is that she gets a lot of help from her friends in relating to her husband.

I would never vote for the POS.


26 posted on 03/29/2020 3:36:02 AM PDT by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
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To: Jeff Chandler

I think that Dr. Ferguson of Imperial University has dialed back his forecasts by a factor of 20 to 25 times. In other words he is backing away from his original forecasts like a crab moving away from a predator. He is admitting that his original forecasts were more than 20 times too high, while attempting to make it look as if he didn’t screw up.


27 posted on 03/29/2020 3:45:39 AM PDT by TheConservativeBanker
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To: Candor7

https://www.youtube.com/watch?v=1TJdjhd_XG8&t=586s

— You should make a separate thread based on this video. A great interview with critical data about treatment for this virus. Everyone should watch this!


28 posted on 03/29/2020 6:37:17 AM PDT by Blennos
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To: Blennos

will do.


29 posted on 03/29/2020 6:38:35 AM PDT by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
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To: Morpheus2009

I think the gene pool is also stronger. A few thousand years of humanity fighting off stuff creates stronger stock.


30 posted on 03/29/2020 6:58:11 AM PDT by cuban leaf (The political war playing out in every country now: Globalists vs Nationalists)
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To: JayGalt

2,229 now in the USA


I just refreshed and it bumped up to 2231. But it still shows 8, daily, for the entire country.


31 posted on 03/29/2020 7:00:07 AM PDT by cuban leaf (The political war playing out in every country now: Globalists vs Nationalists)
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To: nickcarraway

I was wondering about that by my understanding is that they update daily. Could be, though. I need to see what happens tomorrow morning.

It’s frustrating that some of their pages are still up but the numbers are from February.


32 posted on 03/29/2020 7:01:29 AM PDT by cuban leaf (The political war playing out in every country now: Globalists vs Nationalists)
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To: cuban leaf

Are you looming at the bottom at the summation of the new deaths in the individual states today? That is 10 now, and was 525 yesterday correct?
I have seen states not updating at the same time every day. If the 10 holds it would be great news.


33 posted on 03/29/2020 7:27:10 AM PDT by JayGalt (You can't teach a donkey how to tap dance. Nemo me impune lacessit!)
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To: JayGalt

I’ve been following the site for a while and not seen this. They may have changed their stat collection paradigm. We’ll see.


34 posted on 03/29/2020 7:28:48 AM PDT by cuban leaf (The political war playing out in every country now: Globalists vs Nationalists)
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To: cuban leaf

Makes we wonder If The cdc or somebody stopped reporting. Look for free information to stop flowing.


35 posted on 03/29/2020 7:37:57 AM PDT by GulfMan
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To: GulfMan

I’ve gotten to the point that I don’t believe anything they are telling us.


36 posted on 03/29/2020 7:45:35 AM PDT by cuban leaf (The political war playing out in every country now: Globalists vs Nationalists)
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To: TheConservativeBanker
This was a Deep State conspiracy using a mild Chinese bioweapon / bioeweapon "in-progress" that got out too soon; in panic to get rid of President Trump.

Next stage was going to be a Bill-Gates-sponsored mandatory vaccination. Tin foil optional on whether that vaccination had either something nasty in it or something to sterilize the masses.

But they screwed up. They tangled with Donald Trump, whom God has appointed to be President.

...besides, Bill Gates couldn't even protect his own operating system from viruses. Why would anyone trust one of his vaccines?

37 posted on 03/29/2020 7:51:15 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: Jeff Chandler

People neglect the part of that quote where it states “if we do nothing.”

We are doing a shit-ton more than nothing.


38 posted on 03/29/2020 7:53:08 AM PDT by Vermont Lt (.)
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To: nickcarraway

Couple observations:

1) three moonshots

“get antivirals quicker”

- hydroxychloroquine is being ramped up & shipments are arriving

“get respirators and ventilators made cheaper in the United States right now, “

- numerous companies starting production, including auto & 3-d

“work on test kits and to get so many test kits that they’re so cheap, they’re done at home”

- 5 minute test kits are being produced

2) prediction

Quotes old British prediction about cases and deaths in the US”.

This has been since walked back, to far far fewer of each.


39 posted on 03/29/2020 8:27:01 AM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000)
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To: nickcarraway

I have a prediction as far as any future vaccine: it will be costly, and COVID-19 will suddenly be discovered “unstable” in order to create the ongoing revenue stream that they love so much. There was a time not all that long ago when I would have sneered at people ranting about “big pharma” because they were obviously leftists and anti-business to the core. However, since the advent of Obamacare and the pharmaceutical industry jumping in bed with the permanent governing class, the shoe is completely on the other foot. Suspicion is warranted. A quick, simple and cheap treatment for COVID-19 can’t be allowed in the minds of these people. It’s a threat to their little fiefdoms and it’s a threat to a tremendous amount of money coming in annually, to the tune of billions.


40 posted on 03/29/2020 8:41:46 AM PDT by RegulatorCountry
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