Posted on 03/06/2020 8:22:22 PM PST by ConservativeMind
Scientists have just shown that a metabolic pathway plays a determining role in Alzheimer's disease's memory problems. This work, published on 3 March 2020 in Cell Metabolism, also shows that supplying a specific amino acid as a nutritional supplement in a mouse model of Alzheimer's restores spatial memory affected early. This is a promising path for reducing memory loss related to that disease.
The brain uses a large part of the energy available to our body. To work properly, neurons and the surrounding cells, particularly astrocytes, must cooperate. The early phase of Alzheimer's disease is characterized by a reduction in this energy metabolism, but until now we did not know whether this deficit contributed directly to the cognitive symptoms of Alzheimer's disease.
A collaborative study has shown in a mouse model of Alzheimer's disease that a decrease in the use of glucose by astrocytes reduces L-serine production. This amino acid is mainly produced by these brain cells and its biosynthesis path is altered in patients. L-serine is the precursor of D-serine, known to stimulate NMDA receptors, essential for brain function and to the establishment of memory. So by producing less L-serine, astrocytes cause reduced activity in these receptors, which alters neuronal plasticity and the associated memorization capacities. Scientists have also demonstrated that memorization functions in mice were restored by supplying nutritional L-serine.
With the identification of the role of L-serine in memory disorders and the experimental efficacy of nutritional supplementation, new strategies appear that may complement medical treatment, to combat early symptoms of Alzheimer's disease and other diseases that display metabolic deficits, like Parkinson's and Huntington's. Since L-serine is available as a nutritional supplement, this compound should be rigorously tested in humans, through controlled clinical trials.
(Excerpt) Read more at sciencedaily.com ...
It seems worth a try with a loved one.
Geez, I sure hope I remember this article.
Interesting.
I wonder if they’ve studied whether a higher protein diet makes a difference, rather than a supplement.
Traditional Food Items in Ogimi, Okinawa: l-Serine Content and the Potential for Neuroprotection:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343079/#!po=1.08696
Ping!
bookmark
I took some darn good memory caps I will recommend. They really work, but I can’t remember what they’re called anymore.. will share more when it hits me...
Myelin degradation is related to Multiple Sclerosis.
Sounds like limiting sugar would also help, and I think I’ve read that elsewhere, too.
I posted a link to the primary journal article in the other thread.
It’s late and I’m a morning person so I will read the details in the morning.
Preliminary review of the actual research results yielded conflicting results with the magazine article.
how much memory is it restoring? 1%? 10%? 50%?
I’m finding out that nutritional supplements often can perform great things in a person medically with no down-side of side effects, as always happens with pharmaceutical products. I just read in a book by Thomas E. Levy (Magnesium Reversing Disease) that there are indications that olive oil might enable humans to produce their own Vitamin C in their own bodies. I have seen elsewhere that olive leaf extract can combat cancer.
bump
At this point, I think they can get mice to live to 400 years, cure just about anything that’s wrong with them and make them super smart.
That’s great but what about us?
I’m kidding but I feel like I’ve been reading about mouse studies since the 70s.
And I know the little advances made from these tests are great.
But the headlines is always mice takes one pill and gets rid of all his cancer!!
I don’t know if cancer will ever be a one treatment disease.
Thank you for posting. Very interesting
Well, I can remember that I was sppsd to remember something, but cannot remember what I remember i was sppsd to remember. Yet I remember things that I do not want to remember, and remember trying to forget.
In any case, L-Serine can be pretty expensive, though as usual, prices can greatly vary btwn sellers. And the lowest price (not necessarily per mg) I see is Swanson AjiPure L-Serine Vegetable Capsules , 500 mg, 60 Ct for $7.49. Is 500 mg the rec. dosage?
Thanks. Grace and peace thru Jesus the Lord.
I think I remember they were called IIRC.
Me too
Thanks very much for posting!!
For sure.
Some people refer to dementia as Type 3 diabetes, I believe the author of “Grain Brain” is one.
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