Coronavirus Live Weekend Thread.

2/22/20

[Vermont Lt]

A forever thread is getting long. Perhaps a weekly thread?

[Vermont Lt]

It usually starts around 4 pm based on the China numbers coming out from “overnight.” If you go up a few posts you will see the daily thread start.

[Em and Brets Mum]

Got it. Thank you.

[SE Mom]

There are many hospitals (like Hahnemann in Philly) across the country that have closed in recent years. I’m not sure on their present use- could any of them be stood up quickly..

[BobL]

“Nope. This will destroy health care. Completely. Doctors, nurses, hospitals all gone. It’s why they are building dozens of hospitals in China with no doctors and no registered nurses. Just feeder and bucket cleaners. I know a few people I would recommend for that job here in the states.”

It does make sense. Anyone who goes into the environment of a huge room of Coronavirus sufferers will get it, regardless of what they’re wearing...enough of the virus will find its way around it. They’re doomed. So why let anyone in who you need for more important work?

[PA Engineer]

You mean starve a fever, and feed a cold?

Neither. I think we need to allow our bodies to recycle cellular components via autophagy.

Autophagy does not begin until 12 hours after the last meal. The longer the fasted interval, the greater the acceleration of cell recycling. With restricted feeding in a 6 hour window, we enhance this natural process.

There never was scientific evidence supporting three meals a day plus snacking.

Reducing carbohydrate consumption forces the body to begin fat adaption. Removing fructose in particular from the diet also has profound impacts on different hepatic protein expressions.

Best.

[Black Agnes]

I’m wondering if the ketosis/flu thing has something to do with PPAR or MTOR pathways.

Or maybe something else. I wonder if the autophagy goings on help tag the virus as defective kind of like it (autophagy) seems to help with alzheimers and other possibly prionic diseases.

I’ve got a project for this week I guess.

[caww]

Well after a back injury last year I need to put weight on! I dropped from usual weight of 115 to 102 and at 5’2 foot I feel like skin and bones! So what’s the best way to put weight on!

[Black Agnes]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321027/

[Freedom56v2]

Hundreds in Michigan being monitored due to #coronavirus. On Sunday the Michigan Department of Health and Human Services reported that it is currently monitoring 325 people. All of the people being monitored have been to mainland China. No one is being quarantined. (WDIV-TV)

https://twitter.com/howroute/status/1231662347321774083

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Monitored...So if one actually tests positive in a few days the Michigan Dept of Health will have to go back and try to figure out every person the infected person had contact with? Wow so efficient.../S

[angry elephant]

Affecting Iranians in a really bad way too. Perhaps it was designed for them. They have had issues with Muslims lately.

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I seems to affect a lot of people with diabetes type 2. The Chinese have one-third of the world’s people with diabetes type 2. It is also rampant in the Arabic world. There is, as I have been told by Asians and Muslims, a lot of type 2 diabetes due to consumption of rice and pasta.

If not actually on a keto diet, perhaps one might just try to limit carbs to less than 60 per day. People do not need the carbs that 0ur forefather farmers and coal miners or whatever needed. Even in prepping for bad times maybe more preserved meats, vegetables and fruits would be wise versus lots of rice.

[PA Engineer]

I don't know.

We have looked extensively at PPAR in our work on neurodegeneration and studied the effectiveness of medium chain triglycerides (8&10) to bypass defects in the pathways of astrocytes to neurons.

My hypothesis for Alzheimers is insulin resistance (IR) as the fundamental cause for the (6X) proliferation of astrocytes to compensate for the loss of insulin like growth factor signaling.

I believe autophagy enhancement is the result of reversing insulin resistance in Alzheimers. We do get short term gains from Caprylic Acid (C8) Beta-oxidation in astrocytes as well as Capric Acid (C10) lactate pathway shuttle to neurons. This is why some patients improve on coconut oil, however without reversing IR these gains are temporary.

I think metabolic syndrome impedes the autophagy pathway in many systems, however it may be a particular concern with hepatic function during viral infection..

A couple of our new abstracts will be submitted by March 4th (if we travel to the meeting or not is up to the virus). We have circled back to the autophagy pathway to explain iron associated neurodegeneration. So many things can perturb that pathway and we have been lucky to have miRNA studies to demonstrate it. It is like dominoes. You tip one and many processes are effected (either up or down regulated).

I'd like to share a few things we are working on that are not virus related.

For Parkinsons and PKAN, I suspect LAMP5 disfunction plays a very significant role for the iron features we see in the Globus Pallidus (GP). What causes dysfunction of LAMP5 expression takes us back to CoA synthesis as one of the dominoes. LAMP5 is a single domino that ultimately effects lysosome iron recycling. In around about way this takes us back to pantothenic acid deficiency and/or PANK disruption during the entry to the sulfur cycle (CoA pathway). It also may involve cysteine and glutathione peroxidase in another area of the cycle.

We have been puzzled as to why iron deposition is localized to the GP and wether it is an epiphenomena, result of cell survival via ferroptosis or whatever. We are still drilling down and suspect it is a defect at the beginning of the autophagy pathway localized to the GP specifically.

Check out LAMP5 in Protein Atlas: LAMP5. Look at the protein expression location and also click on Brain Atlas tab. Under the Brain Atlas tab is a very good example of mouse models unable recapitulate human disease.

It all makes you go hmmm.

Best.

[bitt]

!!!!!!++

[PA Engineer]

Thank you.

[Black Agnes]

The issues with metabolic syndrome may be implicated in the mortality/morbidity with this one.

I sent you a link on autophagy involvement wrt viruses.

...’it depends’...

it may be a race...

[PA Engineer]

Just got the D3 study. Was that part of it?

[greeneyes]

*** I just did some searching to see if I could find any current info re:Texas. Nope, nothing ***
**********************************************************************************
The John Hopkins Map has 3 cases in Texas. 2@ Lackland from the Diamond Princess, and 1 in San Antonio.

[Black Agnes]

No, different search/link.

Just got to wondering.

We’re taking 10K D3 daily right now and plan on getting sun starting sometime in march when the sun angle gets right here again.

[PA Engineer]

Are you in PA? I don’t think we’ll ever see the sun here again.

[Black Agnes]

No.

But I’m not convinced we’ll ever see the sun again either.

Grand Solar Minimums suck.

[PA Engineer]

I’m working on my cosmic ray tan.