These Scientists Want to Redefine Alzheimer's as a 'Double-Prion' Disease

gizmkodo ^ | Ed Cara

[BenLurkin]

Researchers this week say their work should upturn the conventional narrative of how Alzheimer’s disease happens. They argue the progression of Alzheimer’s is driven by a very specific form of two proteins that play a crucial role in the disease, and these forms should be considered prions—potentially infectious proteins that self-replicate by turning their brethren into a misfolded version of themselves.

To put it simply, people with Alzheimer’s disease have brains that are filled with rigid, clumped-together deposits of the proteins amyloid beta and tau, called plaques and tangles, respectively. It’s long been assumed that if we can stop these deposits, particularly plaques, from happening or break them up, we can delay or outright prevent Alzheimer’s. But this theory has taken a battering in recent years, as trial after trial of anti-amyloid drug has failed to slow down the disease in human patients.

The researchers behind this latest study, based primarily at the University of California, San Francisco (UCSF), are arguing that it’s not the final stages of amyloid beta and tau that are the problem; it’s the earlier, prion-like forms of both proteins that are the real culprits. Plaques and tangles, in this theory, are essentially just the “dead,” inactive remains of amyloid and tau prions.

…

…[T]heyfound clear evidence of amyloid and tau prions spreading throughout the brain, much like classic prions. Another clear link was seen between those with frontotemporal dementia—a disease associated with only tau, not amyloid—and tau prions. ... Those over 80 had the lowest prion levels of all, while the opposite was true in the youngest people who died with an inherited form of Alzheimer’s passed down in families. With tau in particular, the total amount of tau in the brain increased with age even as levels of prion tau declined.

[neverevergiveup]

Alzheimer’s is in large measure a vascular disease (my opinion). One effect of these vascular changes is an alteration in metabolite flux across micro vessels, altering cerebral nutrient delivery, causing mosaic changes in cerebral metabolism, and leading in part to a type of ‘cellular starvation’ of neurons.

[yefragetuwrabrumuy]

Some years ago dentists figured out a correlation between chronic gum disease and Alzheimer’s. Typically bacteria are filtered out by the blood-brain barrier, but there is a direct vascular route from the gums to the brain.

So the dentists figured out that the five types of spirochete bacteria were traveling to the brain, dying, and leaving plaque behind as their remains.

But the solution to this was simple: brush with powdered baking soda, which kills those bacteria in just five seconds; alternating every other day with an ordinary fluoride toothpaste.

Back when baking soda was a common tooth powder, Alzheimer’s was rare. When there was the great shift to toothpaste, plus a few decades, was when Alzheimer’s really took off.

[aimhigh]

Amyloid beta is a bodily response, not the cause. When researchers injected mice with MS with amyloid beta, the mice were cured within two weeks. Test repeated, with same results. Blaming amyloid beta is like blaming a scab for an infection in a skin cut.

[ifinnegan]

UCSF has all the prion-pushing grifters.

[fieldmarshaldj]

*ping of interest*

[dp0622]

It may have to do with skyrocketing ages in the 21st century.

[Trumpet 1]

Baking soda😇 Could be the cure. Thanks.

[SunkenCiv]

This makes some sense. Thanks fieldmarshaldj.

[tired&retired]

Almost enough to get me to stop eating meat.

[captain_dave]

The problem is carbohydrates and sugar. Meat and fat are what we’re supposed to eat.

[Paco]

That’s exactly what I was thinking! ;o)

[Hot Tabasco]

Back when baking soda was a common tooth powder, Alzheimer’s was rare.

I'm not sure it was rare but rather called "senility"......

[Vermont Lt]

Think of all of the cancers and heart issues that people survive these days. Those prevented people from getting dementia, because they died in their 70’s.

[Hot Tabasco]

So true....

[yefragetuwrabrumuy]

A Brief History Of Dementia

https://gerassolutions.com/brief-history-dementia/

However, the dental recognition of a correlation between chronic gum disease and Alzheimer’s, began as just that. People with Alzheimer’s having a history of chronic gum disease, but nothing about Alzheimer’s that would *cause* gum disease.

[Lizavetta]

What do you think about the Bredesen Protocol?