Alzheimer’s is in large measure a vascular disease (my opinion). One effect of these vascular changes is an alteration in metabolite flux across micro vessels, altering cerebral nutrient delivery, causing mosaic changes in cerebral metabolism, and leading in part to a type of ‘cellular starvation’ of neurons.
Some years ago dentists figured out a correlation between chronic gum disease and Alzheimer’s. Typically bacteria are filtered out by the blood-brain barrier, but there is a direct vascular route from the gums to the brain.
So the dentists figured out that the five types of spirochete bacteria were traveling to the brain, dying, and leaving plaque behind as their remains.
But the solution to this was simple: brush with powdered baking soda, which kills those bacteria in just five seconds; alternating every other day with an ordinary fluoride toothpaste.
Back when baking soda was a common tooth powder, Alzheimer’s was rare. When there was the great shift to toothpaste, plus a few decades, was when Alzheimer’s really took off.
Amyloid beta is a bodily response, not the cause. When researchers injected mice with MS with amyloid beta, the mice were cured within two weeks. Test repeated, with same results. Blaming amyloid beta is like blaming a scab for an infection in a skin cut.
UCSF has all the prion-pushing grifters.
*ping of interest*
Almost enough to get me to stop eating meat.