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How catnip makes the chemical that causes cats to go crazy
phys.org ^ | December 10, 2018, | John Innes Centre

Posted on 12/11/2018 6:31:31 AM PST by BenLurkin

The substance that triggers this state of feline ecstasy is called nepetalactone, a type of chemical called a terpene. This simple, small molecule is part of an unusual chain of events, not previously seen by chemists.

The researchers believe that understanding the production of these nepetalactones could help them recreate the way that plants synthesise other chemicals like vinblastine, which is used for chemotherapy. This could lead to the ability to create these useful medicines more efficiently and quickly than we are currently able to harvest them from nature.

Usually in plants, for example peppermint, terpenes are formed by a single enzyme. In their paper published online this week in Nature Chemical Biology, the researchers report that in catnip terpenes are formed in a two-step process; an enzyme activates a precursor compound which is then grabbed by a second enzyme to produce the substance of interest.

This two-step process has previously never been observed, and the researchers also expect something similar is occurring in the synthesis of anti-cancer drugs vincristine and vinblastine from Madagascan periwinkle, Catharanthus roseus, and elsewhere in olive and snapdragon.

In the publication, the team describe the process by which catmint produces nepetalactone in microscopic glands on the underside of its leaves. The study also identifies three new enzymes with unusual activity.

(Excerpt) Read more at phys.org ...


TOPICS: Pets/Animals
KEYWORDS: catnip; kittyping
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1 posted on 12/11/2018 6:31:31 AM PST by BenLurkin
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To: BenLurkin

Ah hah! A terpene is the cause of feline turpitude!


2 posted on 12/11/2018 6:33:42 AM PST by mewzilla (Is Central America emptying its prisons?)
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To: mewzilla

Will it work in womannip?


3 posted on 12/11/2018 6:36:30 AM PST by Bonemaker (invictus maneoOn Monday, an EU court ruled that Britain could reverse its withdrawal unilaterally be)
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To: mewzilla

This is great news!.........If the process can be duplicated in a lab, then scaled up to factory levels, mass producing cancer healing drugs!......................


4 posted on 12/11/2018 6:38:36 AM PST by Red Badger (We are headed for a Civil War. It won't be nice like the last one....................)
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To: BenLurkin

My Kitty is crazy enough

Doesn’t need any help


5 posted on 12/11/2018 6:44:16 AM PST by njslim
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To: BenLurkin

Hope my tomcat doesn’t see this.

Knowing him, he’ll put up a catnip lab in my house.


6 posted on 12/11/2018 6:44:58 AM PST by Catmom (We're all gonna get the punishment only some of us deserve.r)
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To: Bonemaker

:: Will it work in womannip? ::

And will it work in man-nip to cause “tergitude”?


7 posted on 12/11/2018 6:45:17 AM PST by Cletus.D.Yokel (Catastrophic, Anthropogenic Climate Alterations: The acronym explains the science.)
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To: BenLurkin

bookmark


8 posted on 12/11/2018 6:50:57 AM PST by GOP Poet
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To: Bonemaker

Cannabis is loaded with terpenes. They sell soil additives to increase them.


9 posted on 12/11/2018 7:02:30 AM PST by gundog ( Hail to the Chief, bitches!)
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To: Catmom

I have to protect my catnp in a cage. Their used to be a lunatic tomcat around that would roll on the plants until they were a smooth spot in the dirt.


10 posted on 12/11/2018 7:09:11 AM PST by gundog ( Hail to the Chief, bitches!)
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To: BenLurkin

I recently gave one of cats catnip for the first time,, he hasnt been the same since..
tore it up ..


11 posted on 12/11/2018 7:13:51 AM PST by ßuddaßudd ((>> M A G A << "What the hell kind of country is this if I can only hate a man if he's white?")
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To: BenLurkin

Can they modify it to make regular mint intoxicating to humans?


12 posted on 12/11/2018 7:15:41 AM PST by trebb (Those who don't donate anything tend to be empty gasbags...no-value-added types)
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To: gundog

Ours hardly give it notice. They do like to sit out in the herb garden though.


13 posted on 12/11/2018 7:16:33 AM PST by Sequoyah101 (It feels like we have exchaged our dreams for survival. We just ha va few days that don't suck.)
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To: Bonemaker

“Will it work in womannip?”

It’s called chocolate.


14 posted on 12/11/2018 7:19:23 AM PST by READINABLUESTATE
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To: ßuddaßudd

More proof we need drug laws. Cats were once productive members of society, now all they want to do is lay about gettin stoned on the nip!


15 posted on 12/11/2018 7:19:44 AM PST by rawcatslyentist ("All that is necessary for evil to triumph is for good men to do nothing")
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To: READINABLUESTATE

Or, in my case, my hubby.


16 posted on 12/11/2018 7:21:04 AM PST by mewzilla (Is Central America emptying its prisons?)
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To: Sequoyah101

Most of the cats I’ve dealt with were indifferent to it. That particular tom was a real menace. The hummingbirds like it, though.

The plants are good and skunky in the sun.


17 posted on 12/11/2018 7:21:51 AM PST by gundog ( Hail to the Chief, bitches!)
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To: BenLurkin

I have read that feeding catnip to a dog is a good tranquilizer for them. Wonder if this is the ingredient that provides that service.


18 posted on 12/11/2018 7:22:03 AM PST by FrogMom (Time marches on...)
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To: rawcatslyentist
Trust me, lolling nip heads is better than the alternative...

Catnapped

19 posted on 12/11/2018 7:23:09 AM PST by mewzilla (Is Central America emptying its prisons?)
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To: gundog

Not all cats react to catnip. Seems odd if it’s a chemical reaction. You’d think that they’d all respond, though perhaps to different degrees.


20 posted on 12/11/2018 7:30:01 AM PST by SoCal Pubbie
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