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Molecule with anti-aging effects on vascular system identified
Science Daily ^ | September 10, 2018 | Georgia State University

Posted on 09/12/2018 1:46:51 PM PDT by Twotone

A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

"As people become older, they are more susceptible to disease, like cancer, cardiovascular disease and Alzheimer's disease," said Dr. Ming-Hui Zou, senior author of the study, director of the Center for Molecular and Translational Medicine at Georgia State and a Georgia Research Alliance Eminent Scholar in Molecular Medicine. "Age is the most important so-called risk factor for human disease. How to actually delay aging is a major pathway to reducing the incident and severity of human disease.

"The most important part of aging is vascular aging. When people become older, the vessels that supply different organs are the most sensitive and more subject to aging damage, so studying vascular aging is very important. This study is focused on vascular aging, and in old age, what kind of changes happen and how to prevent vascular aging."

In this study, the research team explores the link between calorie restriction (eating less or fasting) and delaying aging, which is unknown and has been poorly studied. The findings are published in the journal Molecular Cell.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Food; Health/Medicine; Science
KEYWORDS: aging; ketone; lowcarb
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1 posted on 09/12/2018 1:46:51 PM PDT by Twotone
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To: Twotone

You go to a pizza party, everyone is eating. Some nibble.

The one guy in back..?

He’s SHOVELING it in. Then he slurps up some sauce. Then guzzles a pitcher of root beer.

THAT was me.

After an important transition period, now I can fast quite easily.

Terry Cruz —he’s the ripped, black, funny ex-NFL guy from White Chicks and Idiocracy:

That guy has done OMAD (One Meal A Day) for over 15 years.

You can do it, too.

Your transition might take a couple weeks but you’ll make it.


2 posted on 09/12/2018 1:51:38 PM PDT by gaijin
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To: Twotone

Considering I’ve been doing intermittent fasting for the last 4 weeks, I’d say that’s good news!!!

I’m fasting because Dr. Jason Fung in his youtube videos claims intermittent fasting cures diabetes. That low carb diets reduce blood glucose but never drop the insulin levels. Fasting drops the insulin levels. And he says that insulin sensitivity is regained long before you lose much weight.

So I’m skipping breakfast, having a 100 calorie cup of chocolate favored bone broth for lunch and eating a good supper with no snacks. Basically a 23 hour fast every work day.

Weight seems to be dropping. Feel good. But I am Hungry. Come on 7pm!!!


3 posted on 09/12/2018 1:52:53 PM PDT by DannyTN
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To: DannyTN

I eat at 5 pm —that’s it. And it’s not a yuge meal.

My first month or so was sorta hard. The first two weeks were very hard.

Now 5 will roll around and often I will FORGET..!

That’s inconceivable a year ago; I’d skip a meal or two and get headaches, get really cranky, etc.

I always thought this fasting business was for hippies and kooks:

I still hate the word, actually.

I was always a gym rat but now I have lost 60 pounds and am still dropping.


4 posted on 09/12/2018 1:57:53 PM PDT by gaijin
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To: DannyTN

Type 1 or Type 2?


5 posted on 09/12/2018 1:58:05 PM PDT by posterchild (anti-science: thinking a fetus is distinct from a tumor and sex is determined by chromosomes)
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To: DannyTN

Jason Fung is awesome.

Go subscribe to Keto Connect on YouTube, they’re very down to earth, and give great consumer tips about Keto dieting:

What to buy to stay slim at Costco, WalMart or Whole Foods, etc.


6 posted on 09/12/2018 2:00:30 PM PDT by gaijin
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To: posterchild

Type 2.

And Dr. Fung primarily is addressing Type 2. Though he does talk about type 1 sometimes. I remember him saying Type 1’s develop symptoms of Type 2 due to too much insulin. So I think fasting might help type 1’s that have type 2 symptoms, but don’t take my word for it.


7 posted on 09/12/2018 2:02:21 PM PDT by DannyTN
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To: Twotone

Good news to hear on a grumpy fast day in Judaism.


8 posted on 09/12/2018 2:03:33 PM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem)
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To: gaijin

I know a guy who did 1 meal a day. He is fat, and recently was diagnosed with type 2 diabetes.
He porked out at that dinner bell.


9 posted on 09/12/2018 2:04:41 PM PDT by vpintheak (Freedom is not equality; and equality is not freedom!)
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To: DannyTN

“Weight seems to be dropping. Feel good. But I am Hungry.”

OMAD works great. If you need something for hunger, try ketone salts. They are minerals complexed with the molecule the article referenced (Beta Hydroxy Butyrate).

They are affordable and easily available now. I use lower dosage than recommended on the label just to take the edge off of hunger. Naturally your system will generate BHB from the fat you are burning with a keto diet.

The supplement form (ketone salts) really helps with One Meal A Day, especially when you are first starting out.


10 posted on 09/12/2018 2:11:18 PM PDT by Zuse (I am disrupted! I am offended! I am insulted! I am outraged!)
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To: gaijin

I come from a family (at least on my mother’s side) where the women have a tendency to be overweight. But they also live well into their 80’s & 90’s while eating, smoking & drinking alcohol to their heart’s content. A lot of longevity comes down to genes. But if a fasting regimen can help prevent things like Alzheimer’s, I’d be inclined to give it a try, just as a preventative measure.


11 posted on 09/12/2018 2:14:14 PM PDT by Twotone
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To: DannyTN

I am using the Bodyfast app only phone (only for 5 days so far) which my old work mate says has given him his 1st 6 pack and ever.

Now he was special forces, did ultra marathons...and into fitness.

So if it is having effects like that on him I am going to give it a try for a few months.

Trying to drop 60 lbs.


12 posted on 09/12/2018 2:15:18 PM PDT by TheErnFormerlyKnownAsBig (We need a consent decree for the FBI like Obama was slapping on all those police agencies.)
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To: Twotone

I’m just having too many intimate dinners for two with just me showing up.


13 posted on 09/12/2018 2:15:59 PM PDT by umgud
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To: gaijin

This Bodyfast app I am trying is intermittent fasting.


14 posted on 09/12/2018 2:16:41 PM PDT by TheErnFormerlyKnownAsBig (We need a consent decree for the FBI like Obama was slapping on all those police agencies.)
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To: vpintheak

“He porked out at that dinner bell.”

Common problem with One Meal A Day.
Try taking some ketone salts before the meal to take the edge off of hunger.
Restrict the time of eating so the one meal does not continue all evening until bedtime.


15 posted on 09/12/2018 2:17:22 PM PDT by Zuse (I am disrupted! I am offended! I am insulted! I am outraged!)
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To: umgud

I have been telling folks I have bulimia...I have the binging part down but I have not yet figured put the purging part...


16 posted on 09/12/2018 2:19:53 PM PDT by TheErnFormerlyKnownAsBig (We need a consent decree for the FBI like Obama was slapping on all those police agencies.)
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To: Twotone

After battling my weight forever I found the simple but difficult thing I needed to do was lower my calorie intake much lower than the medicos would advise. They are convinced no one in my weight class should intake less than 1600 calories per day. Even went through a VA program (worthless) that told me the same thing. Eat a balanced 1600 cal diet and you will lose 1-2 lbs per week. Nonsense.

I lowered my cal intake to below 1200 and started losing weight. The reason it was difficult at first is my stomach had gotten stretched out and used to a certain portion size. By soldiering past the hunger cravings my stomach shrunk so that the smaller portions filled me up. I eat about half of what I did before. I met a heavy set lady at the gym pool a couple of months ago who told me she had lost 250 lbs by cutting her portion size in half. It had taken her 5 years to lose that much weight but by doing it slower; the body gets used to being at that weight and won’t try to gain it back.

Basically I did one of those stomach shrinking surgeries without the surgery and expense or liquid diet.

Now I’m losing about 3/4 - 1 lb a day. If that stops and I’m on the same intake cals then I’ll know my body has lowered its metabolism to prevent me from losing more weight. I’ll know to not get frustrated and just allow my body to adjust. I could add exercise to kick start the weight loss again but I’m not there yet so I’ll just have to wait and see.

After months of struggling, eating well (right things), and going to the gym but only losing 4-5 lbs I kind of gave up. Then an illness kick started me into lowering my cal intake and the lbs started melting off. That was 25 lbs ago. I don’t recommend getting sick to lose weight of course but the lesson is the same and I don’t even go to the gym. Just walk the dogs a few times a week. Some days I have to force myself to eat because I don’t get hungry like I used to before the calorie restricted diet. I keep track of my cals with a free online program called https://www.loseit.com/. Some days I don’t even make it to 900 cals. I think when I reach my target weight I’ll start going to gym a couple times a week. I really do like swimming.

I know some folks do well eating once a day but not all. Better for many to eat 2-3 smaller meals than one large one. I do however splurge at a restaurant once in a while and have 800-1000 cals in one sitting. On those days I don’t have much more than some yogurt or a handful of nuts so my cal count stays low. Once you get used to judging how many cals a meal is; you might be surprised at how much you used to eat. Buffet’s are completely out. Waste of money when you can’t eat more than half a plate at one sitting.

One added benefit besides not lugging around the extra weight is my food bill has been cut in half. Yes!


17 posted on 09/12/2018 2:28:34 PM PDT by Boomer
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To: TheErnFormerlyKnownAsBig

I know you’re joking but throwing up after meals will destroy the esophagus and your teeth. It’s the powerful stomach acids. It also prevents getting any nutrients the body needs to live.

That reminds me. I should supplement with some high quality multi-vitamins.


18 posted on 09/12/2018 2:31:02 PM PDT by Boomer
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To: DannyTN
I’m fasting because Dr. Jason Fung in his youtube videos claims intermittent fasting cures diabetes. That low carb diets reduce blood glucose but never drop the insulin levels. Fasting drops the insulin levels.

Dr Joseph Kraft did a lot of work on insulin. Basically we all have a baseline level. When we eat, it goes up to try to convert food to blood glucose. When we eat sugary food (a.k.a. carbs) insulin goes up more. When we eat low carb, it still spike but not as high. Then it tapers back down to our normal level. For some people that normal level is way high. For others it's normal but it takes a lot longer to come back to it. Dr Kraft laid all that out.

Long and short of it is that low carb does spike insulin less than carby food. Fasting is even better. And if you can keep your insulin levels lower for a while, that normal "baseline level" you walk around with starts to get lower too. That's when you are really flying high. Fasting is the best way to that.

I got all my levels completely under control using intermittent fasting. I became a zealot to the cause. I still am. Yet I've fallen off the wagon. I am trying to get myself back on now. Since falling off, the weight is coming back and I assume the internal damage is also. Articles like this remind me how what I was doing wasn't just about losing weight, it was about reducing risk of cancer, diabetes, and a slew of other conditions. Time to get real again!

19 posted on 09/12/2018 2:37:16 PM PDT by pepsi_junkie (Often wrong, but never in doubt!)
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To: gaijin
Agreed. I've been doing cyclical fasting for a couple of years. The principal is stimulation of autophagy. The three meals a day was never based in science. It was marketing.

For those that worry about coffee, don't. It is actually inductive of the autophagy process:

Coffee induces autophagy in vivo

Further, for those that like cream in their coffee there are MCT oil powders available. Medium chain triglycerides metabolized complete different than long chain. No insulin response and immediate production of ketones.
20 posted on 09/12/2018 2:38:46 PM PDT by PA Engineer (Liberate America from the Occupation Media.)
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