Posted on 02/20/2018 11:06:47 AM PST by Red Badger
Credit: University of Notre Dame
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o stop the spread of cancer, cancer cells must die. Unfortunately, many types of cancer cells seem to use innate mechanisms that block cancer cell death, therefore allowing the cancer to metastasize. While seeking to further understand cancer cell death, researchers at the University of Notre Dame discovered that the activation of a specific enzyme may help suppress the spread of tumors.
The findings, published in Nature Cell Biology, demonstrate that the enzyme RIPK1 decreases the number of mitochondria in a cell. This loss of mitochondria leads to oxidative stress that can potentially kill cancer cells, though researchers speculate the cancer cells could find ways to shut down this effect.
During the study, the Notre Dame team discovered that when the enzyme RIPK1 is activated in a cell, it can cause the number of mitochondria—considered the "power plants" of the cell—to decrease as the cell consumes its own components for energy, a process called mitophagy. This was surprising, given RIPK1 was well-known to regulate necrosis, a completely distinct cell death mechanism.
"We really thought this was going to be a story about necrosis, but we weren't able to see evidence of it, and knew there had to be something we're missing," said Zachary Schafer, Coleman Foundation Associate Professor of Cancer Biology in the Department of Biological Sciences and senior author on the study. "Looking at mitochondrial numbers fundamentally changed our thinking, and got us focused on a different way that RIPK1 may cause cells to die."
Schafer focuses on metastasis, the process by which cancer cells leave the primary tumor and disseminate to other parts of the body. Cell death, a barrier to metastasis, can be induced when epithelial cells, those lining the surfaces of body cavities, detach from the meshwork of scaffolding-like proteins called the extracellular matrix (ECM). As a tumor progresses, it can become resistant to this type of cell death.
"While our findings are in their infancy, we hope we can take advantage of the liability associated with RIPK1's function in order to design a strategy aimed at eliminating ECM-detached cancer cells, which would ultimately improve patient survival," said Mark Hawk, a graduate student at Notre Dame and lead author of the study. Hawk added that more studies are needed to delineate which cancer types are most susceptible to this approach.
Explore further: New paper offers insights into how cancer cells avoid cell death
More information: Mark A. Hawk et al. RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells, Nature Cell Biology (2018). DOI: 10.1038/s41556-018-0034-2
Journal reference: Nature Cell Biology
Provided by: University of Notre Dame
Interesting. Thanks for posting.
There is also substantial research about how calcium overload or underload may kill cancer; and how calcium metabolism is a main culprit in cancer . So some guy has offered why not just take dietary calcium (and some other supplements) that may trigger cancer cell death instead of waiting forever for some drug breakthrough? He would like to know if it works by taking store bought supplements The guy isn’t making any money off this, just summarizing research and providing information to the public.
Do a Google Search for
HOW TO PRODUCE AN INTRACELLULAR CALCIUM DELUGE TO INDUCE CANCER CELL DEATH
Would that not also overload the normal cells as well?
Overload on potassium will stop your heart. I don’t know what calcium overload will do...............
Give you great teeth?
A lot of women in the south could have used this during pregnancy.
Hypercalcemia will induce calcification of soft tissues like the aorta, kidney, and the gut wall. This too will cause death, but you don’t live long enough for cancer to kill you.
The loss of mitochondria lead to more than oxidative stress. Rapidly dividing cancer cells, are simply out of control, and require tremendous energy from the energy power plants, mitochondria. If cancer cells are starved of energy from mitochondria it spells doom, or dormancy for many cancer types.
mitochondria is what Jedi doctors use.
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