Alzheimer's disease - a neurospirochetosis.

The Journal of NeuroInflamation ^ | August 4, 2011 | By Judith Miklossy, MD

[Swordmaker]

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

Judith Miklossy
Correspondence: Judith Miklossy judithmiklossy@bluewin.ch

Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90

Published: 4 August 2011
Abstract (provisional)

It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls. Periodontal pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum, T. medium, T. socranskii) and Borrelia burgdorferi were detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in AD. The pathological and biological hallmarks of AD were reproduced in vitro. The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Persisting inflammation and amyloid deposition initiated and sustained by chronic spirochetal infection form together with the various hypotheses suggested to play a role in the pathogenesis of AD a comprehensive entity. As suggested by Hill, once the probability of a causal relationship is established prompt action is needed. Support and attention should be given to this field of AD research. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

[nutmeg]

Very interesting. How effective is the anti-bacterial mouthwash Cepacol?

[Tammy8]

This really disturbs me, I do some of my cleaning with a Clorox/water solution and have always relied on only the brand Clorox with the blue lid to be actual bleach.

No idea why they would make this change. It makes no sense. I don’t use bleach for my laundry but I would bet I buy more of it than most people for home use.

[Swordmaker]

This really disturbs me, I do some of my cleaning with a Clorox/water solution and have always relied on only the brand Clorox with the blue lid to be actual bleach.

No idea why they would make this change. It makes no sense. I don’t use bleach for my laundry but I would bet I buy more of it than most people for home use.

We did a work up of the amounts of the adulterants added to the varieties of Clorox in their newly concentrated formulas. Where before we recommended a twenty to one mix, it should now be a twenty-four to one to get the same concentration that makes the Dakin's Solution. At 24:1, the other adulterants are well below any danger levels especially as you are not going to drink the stuff.

The least adulterated is the Bacteriological Clorox, designed for disinfecting. That's what we use.

[Swordmaker]

Very interesting. How effective is the anti-bacterial mouthwash Cepacol?

Not very. . . Kill time is about 10-15 seconds. spirochetes will form a protective invulnerable ball in five to seven seconds. The kill time of diluted Clorox is two seconds, too fast for the spirochetes to close up.

[nutmeg]

Kill time is about 10-15 seconds. spirochetes will form a protective invulnerable ball in five to seven seconds. The kill time of diluted Clorox is two seconds, too fast for the spirochetes to close up.

Wow... scary. Not the answer I hoped for, but thank you just the same. Sorry it took me so long to reply to your post. We were away for a week's vacation, with very spotty internet coverage.

[grey_whiskers]

Hi Swordmaker,

I ran across this, long forgotten by me, after a reference to it on another thread.

Do you have any updates on Clorox and/or Damon’s solution?
Is it still the Germicidal, is the solution still 24:1 water to Clorox?

Also is %3 hydrogen peroxide effective for killing spirochetes?

Seriously considering a water pik now.
Must learn to prevent the mess all over the bathroom when I use it.

Thanks!

[Big Red Badger]

20 to one Clorox mixed Daily
for 30 seconds.

[AdmSmith]

Not only to get rid of spirochetes:

Baking soda dentifrice and periodontal health. A review of the literature: Amarpreet Sabharwal, BDS, MS; Frank A. Scannapieco, DMD, PhD

Biofilm associated with healthy gingiva is composed of a limited number of commensal microflora dominated by streptococci and actinomyces. In the absence of oral hygiene, the biofilm becomes more diverse in composition, including an increase in the proportion of gram-negative species and spirochetes, which release various biologically active products, including lipopolysaccharide (endotoxin), chemotactic peptides, protein toxins, and organic acids. These molecules diffuse into the gingival epithelium to initiate the host response that eventually results in gingivitis and in some circumstances, inflammatory periodontal diseases.

There are multiple clinical studies that have measured the effect of baking soda dentifrices in the control of plaque and gingival inflammation. Some studies have not shown baking soda to be comparatively more efficacious in reduction of plaque and gingival inflammation when compared with dentifrices that contain triclosan or herbal ingredients. Conversely, several studies have demonstrated that baking soda dentifrices are superior to control dentifrices in the control of plaque and gingivitis. Overall, there is moderate evidence in favor of clinical efficacy of baking soda dentifrices in controlling plaque and gingivitis.

In a meta-analysis, it was reported that baking soda dentifrices were superior in plaque control of less accessible areas of the dentition.

https://jada.ada.org/article/S0002-8177(17)30823-1/pdf