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p53 and metabolism
Nature Reviews Cancer ^ | October 2009 | Karen H. Vousden & Kevin M. Ryan

Posted on 10/17/2009 12:34:01 AM PDT by neverdem

Nature Reviews Cancer 9, 691-700 (October 2009) | doi:10.1038/nrc2715


Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression...

(Excerpt) Read more at ...

TOPICS: Health/Medicine; Science
KEYWORDS: cancer; metabolism; p53; science
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1 posted on 10/17/2009 12:34:02 AM PDT by neverdem
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To: neverdem
Thanks, bfl.

But now, bed (long overdue).


2 posted on 10/17/2009 12:38:21 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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