Next thing you know you're writing checks to Iron Balls McGinty for one dollar and nine cents.
Posted on 01/08/2026 1:51:21 PM PST by nickcarraway
People who stop taking weight-loss injections such as Wegovy and Mounjaro regain pounds much faster than those who halt exercising and dieting, a new medical study shows.
Research published in The British Medical Journal this month suggests that people lose around a fifth of their body weight when taking the jabs. But once they quit them, they regain 0.8 kg per month on average, meaning they return to their pre-treatment weight in around a year-and-a-half, according to the findings.
The study was based on the analysis of more than 9,000 adults worldwide taking weight management medications (WMMs).
Novo Nordisk, the parent company of Wegovy, told Newsweek that this study "highlights the chronic nature of obesity and suggest that ongoing treatment is necessary."
Eli Lilly and Company, the parent company of Mounjaro, told Newsweek: "When treatment is stopped, weight can return, which reflects the biology of the condition rather than a lack of effort."
Newsweek reached out to the Centers for Disease Control and Prevention (CDC) via email for comment.
The findings come as usage of weight-loss jabs surges in the United States — a Rand Corporation survey from last August found that nearly 12 percent of Americans had used glucagon-like peptide (GLP-1) drugs, including Wegovy and Mounjaro, for weight loss.
The findings also suggest that users need to take the drugs long-term for continued effect, which could have a large financial impact on them.
What To Know
The study, published in The BMJ on January 7, summarized evidence from 37 trials involving 9,341 participants, most of whom received newer "incretin mimetic" drugs such as semaglutide (Wegovy) or tirzepatide (Mounjaro).
The key findings included:
After stopping WMMs, adults regained an average of 0.4 kg (0.9 lb) per month; for newer drugs,
(Excerpt) Read more at newsweek.com ...
“The long term impacts are well studied.”
not really ... at least once a week in it’s daily email to its subscribers, medscape.com includes a recent study that explores a new, common, and sometimes serious side-effect that occurs with these drugs ...
My doctor said she wished it could be put in the water.
No. They don’t.
It might be true that there are “new” studies. But this drug has been around as a treatment for diabetes since 2005. They were first discovered and tested in the 1990s.
If there were long term negative impacts, it would have come to light long ago.
There are a lot of people sucking these things down who have ALL SORTs of problems that are not associated with diabetes. My guess is the new studies are including a lot of people who are “fat shot tourists.”
I have come to understand that my doctor is kind of rare. He was the same one that drove the bus to identify my wife’s diagnosis for pancreatic cancer. Without him, tests would have been delayed and things could have gone poorly.
When I go to see him, the visits often go long because we are having much more involved conversations than most have with their PCPs.
I hope he never retires.
I am fasting today. I have been fasting two days a week for about 13 months. From Sunday night after dinner until Tuesday morning. Then again from Wednesday night after dinner until Friday morning. I started at 213 pounds. I have been as low as 178. My cholesterol dropped from 265 to 205.
Generally, I have plateaued at 180 though. Like during the Christmas/New Years I went back up as high as 189. This morning I was 183. So my weight fluctuates in a 10 pound range depending on how much I stuff in my pie hole.
Haven't been there in years (other than the airport).
I assume you're talking about the Loop?
Good Lord! So now the weight loss self injections (which is fuking insane) are the new Covid jabs… “jab yourself people! You’ll be skinny in no time!”
“Side effects??? Well we don’t quite know about those yet but you’ll be ok. Pinky promise 🤞”
Every time I hear that phrase, I want to punch the person that says it in the mouth.
Everybody can diet, but not everyone can exercise whether it’s from disease or accident. And diet can only be restricted so far when you have poorly understood metabolic dysfunctions that cause weight gain on 600 calories.
You try living like that the rest of your life, mf.
I have a fantastic NP that has steered me right for almost 20 years.
She is as good, if not better as any MD I have ever run into.
Why ask? It's probably the most exercise they get all day.
Yeah, inside...went to Malnati’s and Pequod’s and it was not a calorie deficit...
The way I see it, it’s the drug’s job to get my weight and A1C within proper goals but then it’s MY job to keep it there. These drugs are meant to shrink your stomach so you are less hungry. If you lack discipline, you’ll just Oprah the rest of your life which is bad for your heart. Also, I don’t expect to live forever. If my Lord wants me Home sooner, who am I to argue?
Southern sweet tea has about twice as much sugar as an equal amount of coke. As much as two cups in in 8 cups of tea.
You have a very good 1950s understanding of the problem.
Thats not how it works and discipline has nothing to do with it.
I’ve seen a handful of people in the circles that I run in that have started taking these drugs, and they have seriously lost some weight, like I was questioning if they had a health condition like cancer or something. I wouldn’t doubt the efficacy of them, but it just seems like the full price of using it, I don’t think it’s fully understood yet.
That's not even close to how these drugs work. Why comment when you don't have even the most basic understanding of the medicine's action?
Why would you rely on a drug for weight loss, and think you can then stop it and remain thin?
You can only be thin without the drug if you adjust your diet and exercise.
There is a thyroid cancer risk and others depending on circumstances.
One is blindness.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.