Posted on 08/05/2025 1:18:15 PM PDT by nickcarraway
The pill showed "significant" reductions in airway obstruction after 26 weeks.
1st pill for obstructive sleep apnea could be around the cornerCurrently, many people diagnosed with OSA patients require a machine that covers their nose or both the nose and mouth during sleep and delivers air through a mask to help keep their airways open.
The first oral pill for obstructive sleep apnea (OSA) could be around the corner after pharmaceutical company Apnimed Inc. reported positive results from its stage III clinical trial.
Currently, many people diagnosed with OSA patients require a machine that covers their nose or both the nose and mouth during sleep and delivers air through a mask to help keep their airways open.
Apnimed's lead candidate AD109 showed "clinically meaningful and statistically significant reductions" in airway obstruction after 26 weeks, the company said in a press release.
AD109, a once-a-day pill, is a neuromuscular modulator that increases upper airway muscle tone, which is how contracted the muscles are in the upper airway.
OSA patients treated with the medication saw a nearly 50% reduction in the severity from baseline at week 26, compared to 6.8% of those in the placebo group.
The reduction was "significant" at the end of the study period, which concluded at 51 weeks. At the end of the trial, nearly 23% of participants saw "complete disease control."
The results were part of Apnimed's 12-month study looking at the safety and efficacy of AD109 in adults with mild, moderate and severe OSA.
AD109 was well-tolerated among participants with only mild or moderate adverse events. Which was consistent with prior studies, according to Apnimed. No serious adverse events were reported in the trial.
(Excerpt) Read more at abcnews.go.com ...
There are a few FReepers who just have to bring out the “Don’t be such a fat pig” response any chance they get.
As I said at #41,
There are a few FReepers who just have to bring out the “Don’t be such a fat pig” response any chance they get.
Yeah, I wondered about that.
One of the drugs offered for sleep apnea is Modafinil, which I am mainly familiar with from the military, but I’ve also been prescribed it. Makes you “awake” but not like amphetamines. (You don’t get “high”.)
Doc gave it to me to deal with sleep apnea daytime sleepiness on a “occasional” use basis — after a bad night. Using it too often leads to being “strung out”.
I’d always get a great night sleep that night.
Well, I just looked. It inhibits norepinephrine reuptake.
I do too. The doctor told me that I developed the CSA because of many years of using CPAP for obstructive.
Had the study and surprise surprise, they said I had certainly sleep apnea with over 40 episodes per hour or something (per minutes maybe? Can’t remember now) any way, I got an app for sound recording,on phone, where it only records if there is sound. Listened to a few. Nights worth of sleeping, and did t hear any 40 no-breathing events. It was all steady by breathing.
Try a sound app see if u can hear anything out of ordinary mzybe?
Bkmk
“My sleep study probably saved my life.”
One hour into my sleep study, the RN woke me and said I had sleep apnea. She put me on a CPAP and I slept for six hours without waking. The best night of sleep I had in several years.
The only problem with using a CPAP or BiPap, is that I can no longer blame sleep apnea for falling asleep in committee meetings.
Been using a CPAP with nose pillow mask for over 15 years, and I’m used to it. I have year-round sinusitis that restricts my breathing, especially at night - the CPAP helps keep my sinuses clear as well as my throat. So I won’t be trying any pill.
On the other hand, the NoMask system linked in Post 34 sounds intriguing. A little pricey though. Would be nice to try it before I buy it.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.