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Posted on 08/05/2025 1:18:15 PM PDT by nickcarraway
The pill showed "significant" reductions in airway obstruction after 26 weeks.
1st pill for obstructive sleep apnea could be around the cornerCurrently, many people diagnosed with OSA patients require a machine that covers their nose or both the nose and mouth during sleep and delivers air through a mask to help keep their airways open.
The first oral pill for obstructive sleep apnea (OSA) could be around the corner after pharmaceutical company Apnimed Inc. reported positive results from its stage III clinical trial.
Currently, many people diagnosed with OSA patients require a machine that covers their nose or both the nose and mouth during sleep and delivers air through a mask to help keep their airways open.
Apnimed's lead candidate AD109 showed "clinically meaningful and statistically significant reductions" in airway obstruction after 26 weeks, the company said in a press release.
AD109, a once-a-day pill, is a neuromuscular modulator that increases upper airway muscle tone, which is how contracted the muscles are in the upper airway.
OSA patients treated with the medication saw a nearly 50% reduction in the severity from baseline at week 26, compared to 6.8% of those in the placebo group.
The reduction was "significant" at the end of the study period, which concluded at 51 weeks. At the end of the trial, nearly 23% of participants saw "complete disease control."
The results were part of Apnimed's 12-month study looking at the safety and efficacy of AD109 in adults with mild, moderate and severe OSA.
AD109 was well-tolerated among participants with only mild or moderate adverse events. Which was consistent with prior studies, according to Apnimed. No serious adverse events were reported in the trial.
(Excerpt) Read more at abcnews.go.com ...
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It’s still a big mask. Never bothered.
“Lose your fat and you’ll lose your apnea, in most cases.
Or get a mattress that leans up slightly.”
————
If only it was that simple. First off, I have lost weight and had absolutely zero effect upon my sleep apnea. Second, I have tried the inclined mattress routine at all different kinds of angles, and unless I’m sitting up vertically, it’s not going to work.
“How does a pill affect only the muscle tone of the ‘upper airways’?”
From the underlying study:
AD109 increases upper airway muscular tone primarily through the action of atomoxetine.
Atomoxetine increases norepinephrine levels in the brain by inhibiting its reuptake.
Norepinephrine is a neurotransmitter that enhances the activity of motor neurons controlling upper airway muscles, particularly the genioglossus muscle in the tongue. This muscle is critical for maintaining airway patency during sleep. By boosting norepinephrine, atomoxetine stimulates these motor neurons, leading to increased muscle tone and reduced airway collapsibility, which is beneficial for conditions like obstructive sleep apnea (OSA).
Of course, just assume that there’s a very simple answer to a very complex condition that has multiple potential causes and contributing factors.
My sleep study probably saved my life.
I have snored all my life (even when skinny) and my sleep study registered 94 instances (stopped breathing) per hour, with half of those being central (neurological) events.
This can strain your heart and possibly cause a stroke. There are recent studies showing apnea can damage your brain.
Get the sleep study.
“I know that’s just a prelude to a predetermined diagnosis of “sleep apnea.””
Yep. Selling machines as fast as they can.
It’s like that 70’s Show episode where the modeling “agent” asked the girls to flip their hair then declared them “amazing models”, and for only a bunch of money she would represent them.
“Don’t lose weight, which is what most apnea/snoring comes from. Just take a pill”
I’m right at 9% body fat and have sleep apnea.
I get it from being shaped like the Hulk, which is how I’ve looked since I was about 14.
As noted above, sleep apnea is the bane of almost every every NFL or college football player, wrestler, boxer, and gymnast.
Why is the FDA fast tracking this med?
Lost over 60 pounds, got VERY fit. Made no difference.
I wonder if exercise or general fitness could increase upper airway muscle tone and get the same result.
Remind me again how long it took the C19 vaccine to hit the market.....
Were you told you had to use a CPAP machine to bed?
Best thing ever.
Don’t ignore sleep apnea.
You could be flirting with death every night.
Long term you could end up with congestive heart failure.
Yeah--my sleep study gave up and woke me up after 1.5 hours to put the mask on me.
Yes but yet everyone says they want to die in their sleep. Yet they get a contraption that forces you to ensure you won’t. Doesn’t make sense. So you die from some deadly cancer instead. Nobody said humans were smart.
Been using the full face mask for over 15 years. Annoying at first, but you get used to it. I’ll pass on your magic pills.
Central means that, basically, your brain “forgets” to breath.
Scary crap.
Same here. Had it since I was a kid. Doctors freak out when they see my breathing drop below 12 BPM on their tests. My wife says she doesn't worry as long as I snore every few minutes.
Interesting that the study characterizes Norepinephrine only in terms of the airways in the excerpt you posted. The first paragraph under Norphinephrine in wikipedia talks about it being a alertness and fight-or-flight neurotransmitter also increases heart rate and blood pressure. This seems like a terrible idea for sleep!
Per wiki:
“The general function of norepinephrine is to mobilize the brain and body for action. Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention; it also increases restlessness and anxiety. In the rest of the body, norepinephrine increases heart rate and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal muscle, reduces blood flow to the gastrointestinal system, and inhibits voiding of the bladder and gastrointestinal motility.”
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