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Posted on 08/05/2025 1:18:15 PM PDT by nickcarraway
The pill showed "significant" reductions in airway obstruction after 26 weeks.
1st pill for obstructive sleep apnea could be around the cornerCurrently, many people diagnosed with OSA patients require a machine that covers their nose or both the nose and mouth during sleep and delivers air through a mask to help keep their airways open.
The first oral pill for obstructive sleep apnea (OSA) could be around the corner after pharmaceutical company Apnimed Inc. reported positive results from its stage III clinical trial.
Currently, many people diagnosed with OSA patients require a machine that covers their nose or both the nose and mouth during sleep and delivers air through a mask to help keep their airways open.
Apnimed's lead candidate AD109 showed "clinically meaningful and statistically significant reductions" in airway obstruction after 26 weeks, the company said in a press release.
AD109, a once-a-day pill, is a neuromuscular modulator that increases upper airway muscle tone, which is how contracted the muscles are in the upper airway.
OSA patients treated with the medication saw a nearly 50% reduction in the severity from baseline at week 26, compared to 6.8% of those in the placebo group.
The reduction was "significant" at the end of the study period, which concluded at 51 weeks. At the end of the trial, nearly 23% of participants saw "complete disease control."
The results were part of Apnimed's 12-month study looking at the safety and efficacy of AD109 in adults with mild, moderate and severe OSA.
AD109 was well-tolerated among participants with only mild or moderate adverse events. Which was consistent with prior studies, according to Apnimed. No serious adverse events were reported in the trial.
(Excerpt) Read more at abcnews.go.com ...
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Lose your fat and you’ll lose your apnea, in most cases.
Or get a mattress that leans up slightly.
cyanide?.....................
No thanks. I’ve discovered over the years and thru many friends and relatives that there is no magic pill.
I’ve had it since I weighed 135 pounds and wrestled in the 141 pound class back in the 90s.
It’s not always weight.
“Lose your fat and you’ll lose your apnea, in most cases.
Or get a mattress that leans up slightly.”
I’m extremely lean and do the bed tilt thing. Doesn’t do a thing.
Reluctantly wear the fighter mask.
Men with thick necks and a mesomorphic build just get it. My doctor works with NFL players. Basically all of them have sleep apnea. Boxers, too.
I’ll absolutely be first in line for this. Can’t use the mask during allergy season.
See my post above.
Step on the gas!
OK, now develop a pill for my pecs, delta, triceps, biceps, quads, and glutes.
Did you ever try EPAP?
Don't lose weight, which is what most apnea/snoring comes from. Just take a pill.
Unfortunately, I have obstructive and central apnea.
Central means that, basically, your brain “forgets” to breath.
Scary crap.
I’ve seen all kinds of “miracle” pillows that are supposed to solve the problem.
I’ve ignored the diagnosis. I refuse to sleep with a machine. So did my registered nurse friend.
No magic pill sounds about right to me too.
How does a pill affect only the muscle tone of the ‘upper airways’?
I’m guessing there would be a LOT of side effects.
Also, why does it take a full 26 weeks (half of a year) to get 50% efficacy? Why so slow acting at such a low rate?
We did a lot of neck bridges back in the day and my doctor said I just have the anatomy for apnea. So you’re right.
After 6 months? Hardly worth looking at.
I have a co-worker that uses the apnea mask. He says it wakes him up about three times a night.
My doctor has been pushing me to get a sleep study done, but I know that’s just a prelude to a predetermined diagnosis of “sleep apnea.”
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