Posted on 03/13/2025 3:09:00 PM PDT by ConservativeMind
New therapies for managing aging could emerge from research into a new gene, which scientists have identified as a key driver of degeneration.
Age-related diseases are strongly linked to inflammation which, when chronic, albeit low-grade, contributes to conditions such as cardiovascular disease, diabetes, neurodegeneration, and sarcopenia.
In a study, Dr. Ildus Akhmetov uncovered groundbreaking insights into the role of the Ectodysplasin A2 Receptor (EDA2R) in this process.
EDA2R, a member of the tumor necrosis factor receptor family, specifically binds to the EDA-A2 protein and is involved in apoptosis, or cell death, and inflammatory signaling.
The team identified a striking, tissue-independent correlation between EDA2R expression and age. Across diverse human organs and tissues, EDA2R consistently emerged as the top gene associated with aging.
These findings were further validated in rodent models, with particularly pronounced effects of accelerated aging. Elevated EDA2R expression was linked to transcriptional changes associated with inflammation and vascular dysfunction—hallmarks of aging.
However, Dr. Akhmetov's team revealed that EDA2R functions not only as a biomarker of chronic inflammation but also as a potential driver of the aging process itself.
In cellular models, EDA2R overexpression triggered inflammatory signaling and disrupted muscle health pathways, mimicking key features of aging-driven sarcopenia, the progressive loss of muscle mass and strength. Conversely, EDA2R inhibition mitigated these detrimental effects.
To extend their analysis, the team examined blood samples from 5,228 individuals, revealing a strong correlation between EDA2R expression and systemic inflammation, as indicated by elevated C-reactive protein levels.
And he said there was already evidence that reducing EDA2R levels could be beneficial.
"The literature and our preliminary data indicate that calorie restriction, physical activity, the dietary supplement ginkgo, and the widely prescribed glucose-regulating medication metformin can reduce EDA2R levels in animal models and human subjects.
"This suggests a promising strategy for mitigating aging-related inflammatory processes."
(Excerpt) Read more at medicalxpress.com ...
"The literature and our preliminary data indicate that calorie restriction, physical activity, the dietary supplement ginkgo, and the widely prescribed glucose-regulating medication metformin can reduce EDA2R levels in animal models and human subjects.“
So how about regulating your glucose load via diet?
Metformin, I have prescription bottles with that name on them. They are still full after all this time. Cut the carbs, magical things happen.
Exactly. Glucose is probably the highest contributor to systemic inflammation by far.
Good for you!
Metformin … another miracle drug.
So many benefits.
I wonder if any of the study subjects who took the combo (Ginko and metformin) were non-diabetics.
Would be good info to know, for those of us who are not.
(Apologies if the article explains this. Thx, as always, for posting/pinging.)
Epitalon, BPC-157, GHK, Thymosin B4(TB500), Ipamorelin, CJC-1295 and other peptides all have been shown to have rejuvenating affects.
Not cheap, and not recommended without guidance from a professional.
All pose very little risk, and lots of reward.
Cut the carbs, magical things happen.
Indeed!
Congrats. Keep up the great work.
Although, you may want to hold on to them. Metformin has other benefits, so I’ve read.
That doesn’t work in insulin response resistant people.
That’s exactly who should be dedicated to low-carbing it.
What? You never dealt with naturally thin and fortunate gene people and their bigotry toward anyone else? You should pay attention since they know all the answers.
I did a quick search on my variants for this gene. Too tired to look at all the variants but i do have red flags on that gene.
One is related to male pattern baldness. Yep, runs in my family.
I tried to see if you could order your own blood test for this to see your levels but didnt see anything.
Just shut up and eat your salad with vinegar and avacado oil, no one wants to hear about your diet.
I was on a low carb no sugar diet for awhile, didn't lose any weight. In fact, it was, The Worse 3 hours of my life!!!
Why are you still bombarding the forum?
Good info! Thanks for post
Recal my folks taking Ginkgo when I was a teenager
Thanks
BKMK
Because I still want to annoy you.
Cut the carbs and sugar. Avoiding soda pop will add a lot of years to your life.
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