Targeted vitamin D supplementation strategies show promise in boosting cardiometabolic health

Medical Xpress / Engineering Journal / Engineering ^ | Sept. 10, 2024 | Peng An et al

[ConservativeMind]

A systematic review and meta-analysis conducted by scientists has uncovered promising insights into how vitamin D supplementation can significantly impact cardiometabolic health.

The study has implications for tailored therapeutic strategies targeting cardiovascular diseases and related risks.

The comprehensive review analyzed 99 randomized controlled trials (RCTs) involving a total of 17,656 participants. The analysis revealed that vitamin D supplementation, with a median dose of 3,320 International Units (IU) per day, was associated with favorable effects on various cardiometabolic risk factors, including reductions in systolic and diastolic blood pressure, total cholesterol, fasting blood glucose, hemoglobin A1C, and fasting blood insulin.

Significantly, the researchers discovered that the benefits of vitamin D supplementation were most pronounced in specific groups: non-Western populations, individuals with baseline 25-hydroxyvitamin D levels below 15.0 ng·mL−1, those with a body mass index (BMI) below 30 kg·m−2, and older individuals aged 50 years or above.

This research underscores the need for personalized vitamin D intervention strategies, taking into account individual characteristics such as ethnocultural background, age, BMI, and baseline vitamin D levels. The findings highlight the potential of longer intervention durations (three months or more) and higher doses to optimize cardiometabolic health outcomes in specific populations.

These findings could lead to significant advancements in preventive medicine and nutritional sciences, potentially leading to the development of more effective public health strategies. By tailoring vitamin D supplementation based on individual characteristics, health care providers may improve intervention efficacy and reduce the prevalence of cardiometabolic diseases.

The authors suggest that future research should focus on elucidating the mechanisms behind these observed effects and the potential benefits of vitamin D supplementation on chronic diseases such as cardiovascular diseases. Additionally, studies exploring the long-term effects and potential risks associated with high-dose supplementation are warranted.

[ConservativeMind]

This is a metastudy that tells much the same as prior studies, but doctors can now point to this and say, “The metastudy finally proves it.”

Regardless, they do sum up populations getting the 3,320 IU a day of vitamin D most helped:

“Significantly, the researchers discovered that the benefits of vitamin D supplementation were most pronounced in specific groups: non-Western populations, individuals with baseline 25-hydroxyvitamin D levels below 15.0 ng·mL−1, those with a body mass index (BMI) below 30 kg·m−2, and older individuals aged 50 years or above.”

[ConservativeMind]

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[Uncle Miltie]

My 2 pills per day yield a blood measure of “63” whatevers per whatever, which I understand to be slightly on the higher than average side of the good range.

[Leaning Right]

Interesting post (as usual), CM.

The study says a vitamin D dosage of 3,320 IU a day is quite beneficial.

The Mayo Clinic agrees that the proper vitamin D dosage can do many good things. They say up that to 2,000 IU a day is “generally safe” and 60,000 IU is toxic.

Hmm. I guess 3,320 IU is fine.

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-how-much-vitamin-d-do-i-need/

https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-d-toxicity/faq-20058108

[minnesota_bound]

This guy says you need more vitamin D if you have these issues.
I went from 10,000IU to 20,000 recently after seeing this.

Dr Eric Berg
11 Bizarre Symptoms of Vitamin D Deficiency (You NEED to Know)
https://www.youtube.com/watch?v=AXq2ZdXXFCU

I also recently started to take B1 as a orange flavor gummy.

Vitamin B1 (Thiamine) Deficiency Signs, Symptoms, and Treatment Benefits
https://www.youtube.com/watch?v=vppzm2NsIYo

[sauropod]

Bkmk

[Rockingham]

My surmise is that the somewhat equivocal results as to the benefits of Vitamin D supplementation for the cardiovascular system is the importance of magnesium status. The two nutrients are closely related in energy metabolism, but magnesium is hard to measure because it mostly resides inside the cells, with blood levels often a poor indicator.

Moreover, magnesium deficiency is common, with magnesium tending to be inadequate in processed foods, poorly absorbed, and easily eliminated by common diuretics and proton pump antacids. The best corrective supplements are in amino acid chelated form, with magnesium L-threonate the best in transiting the blood-brain barrier.

Notably, inadequate magnesium tends to promote calcium retention and calcification in the cardiovascular system. Residents in areas with magnesium rich hard water tend to have better cardiovascular health. I suspect that magnesium rich domestic and bottled water may be one of the reasons for the so-called French paradox of a rich diet but relatively good cardiovascular health.

The bottom line: if you are taking vitamin D for cardiovascular health, add in magnesium as magnesium glycinate or magnesium L-threonate.

[Red Badger]

That’s me all over!...................

[Seaplaner]

Good call, my FRiend.

Another consideration is adding vitamin K2-MK7 to the supplement list.

[goodnesswins]

Bfl

[Rockingham]

And nattokinase to help reduce arterial fibrosis.

[WhattheDickens?]

Ping! Vitamin D and magnesium

[jmmec2014]

Be careful, Dr. Berg is not a medical doctor (also deeply intwined with Scientology if that is of concern to you).

[minnesota_bound]

Thanks. I just did a search and you are right. Anyone who is involved with Scientology is a a nut.

Search: Dr. Eric Berg and Scientology

This is his son’s video...

What it’s like to work for Dr. Eric Berg (SPOILER…ITS LIKE A CULT) - Ex Scientologist and the son of health guru Eric Berg speaks out about his strong connections to Scientology.
https://www.reddit.com/r/scientology/comments/10it7an/what_its_like_to_work_for_dr_eric_berg_spoilerits/

[dennisw]

Good video by Berg and thanks! Just ordered, 10000 iu D3
https://www.amazon.com/gp/product/B0BN6WYGZR/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1

I have some 10000 iu D3 in my fridge but I think they are getting old

[dennisw]

Berg is a chiropractor, and I overlook his Scientology connection. I never see him giving crap advice.