Posted on 09/06/2024 5:28:55 AM PDT by Red Badger
A study led by The University of Texas at Austin has identified SC27, an antibody capable of neutralizing all known variants of the COVID-19 virus, opening prospects for universal vaccine development and improved treatments amid ongoing viral evolution.
Researchers have identified an antibody capable of neutralizing all known strains of SARS-CoV-2, the virus responsible for COVID-19, and several other SARS-like coronaviruses found in different animals.
As part of a new study on hybrid immunity to the virus, the large, multi-institution research team led by The University of Texas at Austin discovered and isolated a broadly neutralizing plasma antibody, called SC27, from a single patient. Using technology developed over several years of research into antibody response, the team led by UT engineers and scientists obtained the exact molecular sequence of the antibody, opening the possibility of manufacturing it on a larger scale for future treatments.
“The discovery of SC27, and other antibodies like it in the future, will help us better protect the population against current and future COVID variants,” said Jason Lavinder, a research assistant professor in the Cockrell School of Engineering’s McKetta Department of Chemical Engineering and one of the leaders of the new research, which was recently published in Cell Reports Medicine.
Evolution of COVID-19 and the Role of SC27
During the more than four years since the discovery of COVID-19, the virus that causes it has rapidly evolved. Each new variant has displayed different characteristics, many of which made them more resistant to vaccines and other treatments.
Protective antibodies bind to a part of the virus called the spike protein that acts as an anchor point for the virus to attach to and infect the cells in the body. By blocking the spike protein, the antibodies prevent this interaction and, therefore, also prevent infection.
SC27 recognized the different characteristics of the spike proteins in the many COVID variants. Fellow UT researchers, who were the first to decode the structure of the original spike protein and paved the way for vaccines and other treatments, verified SC27’s capabilities.
The technology used to isolate the antibody, termed Ig-Seq, gives researchers a closer look at the antibody response to infection and vaccination using a combination of single-cell DNA sequencing and proteomics.
Toward a Universal Vaccine “One goal of this research, and vaccinology in general, is to work toward a universal vaccine that can generate antibodies and create an immune response with broad protection to a rapidly mutating virus,” said Will Voss, a recent Ph.D. graduate in cell and molecular biology in UT’s College of Natural Sciences, who co-led the study.
In addition to the discovery of this antibody, the research found that hybrid immunity — a combination of both infection and vaccination — offers increased antibody-based protection against future exposure compared with infection or vaccination alone.
The work comes amid another summer COVID spike. This trend shows that while the worst of the pandemic may have passed, there’s still a need for innovative solutions to help people avoid and treat the virus.
Reference:
“Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination” by William N. Voss, Michael L. Mallory, Patrick O. Byrne, Jeffrey M. Marchioni, Sean A. Knudson, John M. Powers, Sarah R. Leist, Bernadeta Dadonaite, Douglas R. Townsend, Jessica Kain, Yimin Huang, Ed Satterwhite, Izabella N. Castillo, Melissa Mattocks, Chelsea Paresi, Jennifer E. Munt, Trevor Scobey, Allison Seeger, Lakshmanane Premkumar, Jesse D. Bloom, George Georgiou, Jason S. McLellan, Ralph S. Baric, Jason J. Lavinder and Gregory C. Ippolito, 1 August 2024, Cell Reports Medicine.
DOI: 10.1016/j.xcrm.2024.101668
The researchers have filed a patent application for SC27. Other members of the team from UT are Jason McLellan, Patrick O. Byrne, Sean A. Knudson, Douglas R. Townsend, Jessica Kain, and Yimin Huang of the Department of Molecular Biosciences; George Georgiou, Ed Satterwhite, and Allison Seeger of the McKetta Department of Chemical Engineering; Jeffrey M. Marchioni of the Department of Biomedical Engineering; and Chelsea Paresi of the Department of Chemistry. Team members from other institutions include Greg Ippolito of the Texas Biomedical Research Institute; Ralph S. Baric, Michael A. Mallory, John M. Powers, Sarah R. Leist, Jennifer E. Munt and Trevor Scobey of the University of North Carolina at Chapel Hill’s Department of Epidemiology; Izabella N. Castillo, Melissa Mattocks and Premkumar Lakshmanane of UNC’s Department of Microbiology and Immunology; and Bernadeta Dadonaite and Jesse D. Bloom of Fred Hutchinson Cancer Center. The research team received funding from the National Institutes of Health and the Bill & Melinda Gates Foundation.
\ Excepting from the title: "imprinted by infection or vaccination."
So "safe and effective" as was the marketing and politics of the "event" was neither fully safe nor fully effective.
From the Discussion section: "Clinical data suggest that any prior exposure to SARS-CoV-2, whether through infection or vaccination, significantly reduces the severity of subsequent infections."
Seems as if natural immunity from a healthy immune system is far safer and more effective. And the many boosters show themselves a marketing gimmick.
Even though the study was a very small sample, the rigor was clear.
The hot link is very much appreciated. And the actual, documented mortality rate worldwide over the entire course of the 'pandemic" stands at about 0.08 percent. Seems the pandemic was most visible in the media hype. And the politics.
Unfortunately there is no antibody that protects you from kneeling down to authoritarian rule and taking the clot shot.
In the scamdemic the so-called remedy was as bad if not worse than the kung flu.
who will get the patent royalities?
p
My antibodies are just fine, thank you.
That should shake out the dead bodies.
Good rule of thumb!
So the COVID thing really is over only not how they ever thought or imagined.
Just say nay!
Bkmk
Ping
This looks promising. Not signing up for a shot anytime soon.
Antibodies are not MRNA spike proteins. Every human on earth makes antibodies everyday all the time to a number of pathogens. They hit the genetic lottery and found a human who’s body made an antibody that can attach itself to any SARS like spike protein that’s is a huge discovery. That one person could save millions now. It’s not hard once you sequence the antibodies RNA to clone it. You clone the antibodies not make MRNA out of it. This exactly what Eli Lilly did in the heart of the pandemic they cloned human antibodies and distributed them for IV use in the first 5 days of illness. Countless lives were saved mine was one of them. I own 50,000 in Eli Lilly stock as pay back for them saving my life. I was at 65% blood oxy and 104F fever by day five of covid for me. I was technically outside the window for the emergency use licence my GP gave it to me anyways as compassionate use since I was already on the way to a ventilator and 100% O2 at 4L per min. 8 hours after the antibodies infusion my fever was down too 102 and my blood oxy up to 70, 24 hours later I was under 100F and mod 70s by day four after I was mid 80s and on my way out of the hospital nothing short of amazing. I never took any of the vaccines since I sequestered for the first 10 months doing remote drilling via 4/5G or solo field geology work far from people. It wouldn’t be till Sept 21 when I would finally need covid head to head. There is no need to poo poo cloned antibodies they are identical to what the original human body made in the first place. Of course you can take the RNA sequence of this antibody and then make a MRNA sequence as a injectable spike protein which would then teach the host mitochondrial DNA how to make the antibodies skipping the cloning in vats process but that gets people all wound up about MRNA when there is no need for that when you can make the antibodies directly by cloning them. This is what saved the Don’s life he also got monoclonal antibodies that were cloned from a human I think he got the Eli Lilly version too.
Monoclonal antibodies are not a shot they are a IV infusion and they are only given AFTER someone is sick and their own immunities have failed.
Yes you can also take the RNA sequence of this antibody and then make a MRNA sequence out of it for injection into a host’s mitochondrial cells. Those cells will then crank out the antibodies RNA code like a copy machine.
The two are not anywhere near the same thing. It pays to know and understand the difference. One is cloned antibodies from a human being vat grown and infused via an IV drip. The other is just the RNA sequence made into MRNA for injection into host cells for replication of that RNA.
Your experience was about the same as one of my friends who contracted Covid in December 2020. His blood O2 dropped to the same dangerous level and they did ventilate him. He eventually developed AKI, acute kidney injury, and every time that they tried dailysis his blood pressure soared and they had to halt. He lasted maybe a week once the AKI started.
I occasionally get a ‘chimeric murine humanized mAB’ designed to suppress part of the immune system. I don’t know if mRNA could generate that mAB but it would sure beat sitting for hours attached to an IV drip line.
No. "Safe and effective" means that the drug manufacturers demonstrated that the drug meets FDA safety requirements during clinical trials and that the drug meets or exceeds the efficacy goals as defined prior to initiation of clinical trials. The efficacy goals would have been stated to indicate that serious illness was prevented in some percentage of the vaccine recipients.
If drug developers cannot demonstrate both safety and efficacy, drug development halts. The FDA will not approve any drug that fails to meet minimal safety or efficacy standards.
Seems as if natural immunity from a healthy immune system is far safer and more effective. And the many boosters show themselves a marketing gimmick.
"Natural immunity" is an antivax term that is not used by real scientists. It is designed to make those seeing or hearing it that somehow, disease-induced immunity is safe and natural while vaccine-induced immunity is unsafe and unnatural. In reality, the function of the immune system is completely natural no matter whether an active pathogen or an inactive antigen (a protein that stimulates immune activity) stimulates immune activity. It is difficult to even imagine what an "unnatural" immune response would be since, scientifically, it cannot exist. And as for the notion that it is safer to catch the disease than it is to get vaccinated, the data says otherwise. As of September 9, 2023, over 1.1 million people in the US had died of Covid. The number of deaths that occurred around the time of vaccination (but are not necessarily caused by it) is still in the low double digits. So the notion that getting vaccinated is more dangerous than catching a deadly disease is exaggerated by a few hundred thousand fold.
As for the necessity of taking periodic boosters, this is typical for almost all vaccines. This is because the immune system does not remember pathogens forever. The fact that people who have had Covid catch it repeatedly demonstrates that disease-induced immunity is no more durable than vaccine-induced immunity.
And the actual, documented mortality rate worldwide over the entire course of the 'pandemic" stands at about 0.08 percent.
Stating the death rate as a function of the entire population instead of those who actually catch the disease is another way professional antivaxxers gaslight people. The death rate at the population level is meaningless when determining how deadly a disease is. The real death rate of Covid is around 1% for someone who has no preexisting immunity from vaccination or disease. To illustrate, in 2021, five people in the US died from rabies. Comparing the number of deaths to the population comes out to a 0.0000015% death rate from rabies. So, as a function of population, rabies is about 53 thousand times less likely to kill than Covid. But you would be a fool to refuse rabies treatments if you have been bitten by a laboratory-confirmed rabid animal, because the real death rate of symptomatic rabies is 100% (once symptoms appear). I am not counting the handful of cases in which the rabies patient survived thanks to radical medical interventions.
People are still dying from Covid and it is still in the top ten causes of death. It isn't over (thanks to the extreme efforts of professional antivaxxers to spread misinformation and interfere with pandemic control measures), it just is no longer a daily news item.
In other words, you happily take the Covid shots since the mRNA vaccine platform has been in development since the 1990s, or for about 30 years!
Professional antivaxxers? Meaningless?
mortality rateYour seeming accusation that I am a "professional antivaxxer" is uninformed at the minimum.
If you don't like the official definition of mortality rate, cite a source for your 'other' definition or source attesting to your assertion that a mortality rate is "meaningless."
Instead of a 99.8% recovery rate for the majority of people by default without any medicine. You can now take a future pill and be 100% cured.
This does not cure the new bio weapons the democrats and communists are working on.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.