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Long-term use of certain acid reflux drugs linked to higher risk of dementia (PPIs)
Medical Xpress / American Academy of Neurology / Neurology ^ | Aug. 9, 2023 | Carin Northuis et al

Posted on 08/13/2023 8:52:23 PM PDT by ConservativeMind

People who take acid reflux medications called proton pump inhibitors for four-and-a-half years or more may have a higher risk of dementia compared to people who do not take these medications, according to research. This study does not prove that acid reflux drugs cause dementia; it only shows an association.

"Proton pump inhibitors are a useful tool to help control acid reflux, however long-term use has been linked in previous studies to a higher risk of stroke, bone fractures and chronic kidney disease," said study author Kamakshi Lakshminarayan, MBBS, Ph.D.

The study included 5,712 people, age 45 and older, who did not have dementia at the start of the study. They had an average age of 75.

Participants were then followed for a median duration of 5.5 years. During this time, 585 people, or 10%, developed dementia.

Of the 4,222 people who did not take the drugs, 415 people developed dementia, or 19 cases per 1,000 person-years. Person-years represent both the number of people in the study and the amount of time each person spends in the study. Of the 497 people who took the drugs for more than 4.4 years, 58 people developed dementia, or 24 cases per 1,000 person years.

After adjusting for factors such as age, sex and race, as well as health-related factors such as high blood pressure and diabetes, researchers found people who had been taking acid reflux drugs for more than 4.4 years had a 33% higher risk of developing dementia than people who never took the drugs.

Researchers did not find a higher risk of dementia for people who took the drugs for fewer than 4.4 years.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: absolutehorsepuckey; acid; antacid; dementia; eatcabbage; loseweight; medicalxpress; ppi; reflux
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To: jimtorr

I take an occasional Antacid tablet...says calcium carbonate is main ingredient.


21 posted on 08/13/2023 11:52:55 PM PDT by spokeshave (Proud Boys, Angry Dads. Grumpy Grandads & Curmudgeons)
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To: entropy12
Reading too many such articles will cause dementia and paranoia.

Thar's yr test.

If you can concentrate long enough to read that article...and can remember it to post here...and can manipulate your computer to get here you don't have any dementia.

22 posted on 08/13/2023 11:56:24 PM PDT by spokeshave (Proud Boys, Angry Dads. Grumpy Grandads & Curmudgeons)
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To: ConservativeMind

Everyone on antacids should want know if the real root of their problem is helicobacter pylori infection.


23 posted on 08/14/2023 12:08:46 AM PDT by inchworm (al )
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To: Sarah Barracuda

I thought it was Zantac gonna do me in?

Hope Cimetidine isn’t a PPI.

Oh well.


24 posted on 08/14/2023 12:08:56 AM PDT by Salamander (Please visit my profile page help save my beloved dog's life. https://www.givesendgo.com/G2FUF)
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To: entropy12

Voting Democrat would be a better sign of dementia & paranoia.


25 posted on 08/14/2023 12:56:55 AM PDT by bobcat62
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To: Drew68

Yeah, I think that the very high aspirin content of Alka-Seltzer would be problematic on a long-term basis. But I totally agree with you, that it’s a great antidote to a “heartburn” situation. I really like the taste especially when used with very cold water.
“Plop, plop, fizz, fizz, oh what a relief it is.”


26 posted on 08/14/2023 1:08:15 AM PDT by irishjuggler
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To: madison10

Same for me. I’ve been taking Omeprazole daily for about 5 years.


27 posted on 08/14/2023 1:11:54 AM PDT by FLT-bird
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To: ConservativeMind

If this country had any health care worth a damn:

1. Many cases of reflux are linked to hiatal hernia. Fix the hernia and the reflux goes away. But a bottle of pills is much cheaper.

2. Lose 20-or more pounds and the reflux often goes way or gets better. Treat obesity.

3. Don’t eat 1/2 a pizza before going to bed and you won’t wake up with what seems like beans in you mouth in the middle of the night. Target behaviors that make the condition worse.


We in the US spend MOST of our money in health care on diseases which folks have brought on themselves through obesity, bad diets, bad eating habits, sexual behaviors, drug use, lack of movement, smoking, excessive drinking, ignoring what was a smaller condition until it became a huge problem.

Most of the reflux is behavior based. Almost all your HIV is behavior based, so is syphilis, clamidia, ghonnoria... much of you cardio vascular disease, diabetes, kidney, lung/COPD, are behavior based. The reason we’re not getting older isn’t how much we spend on health care, but rather how we choose to live our lives.

But, in the meantime, we get our solutions from geniuses like Chris Christie, a human tub of lard. He won’t address the std problem as he promotes the populist LGBTQIA agenda, wants more socialized health care, bla bla bla.


28 posted on 08/14/2023 1:28:27 AM PDT by Red6
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To: madison10

Ditto. One time release Omeprazole every morning. Makes life worth living.


29 posted on 08/14/2023 2:20:16 AM PDT by MayflowerMadam
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To: ConservativeMind

bttt


30 posted on 08/14/2023 4:33:01 AM PDT by Ann Archy (Abortion....... The HUMAN Sacrifice to the god of Convenience.)
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To: ConservativeMind

Bookmark


31 posted on 08/14/2023 5:16:24 AM PDT by DocRock
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To: Political Junkie Too

That was my go to recipe. It stops it right now.

But what really ended my heartburn was losing 50 pounds and no more alcohol. And I mean ended, as in no more heartburn, ever.


32 posted on 08/14/2023 5:53:02 AM PDT by GrannyAnn ( )
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To: ConservativeMind

“benefits outweigh risks.”

/s


33 posted on 08/14/2023 6:13:01 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: ConservativeMind

Most people need MORE acid...look into stomach acid test ... probably should be taking HCL W/Betaine


34 posted on 08/14/2023 6:37:14 AM PDT by goodnesswins ( We pretend to vote and they pretend to count the votes.)
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To: ConservativeMind

https://medlineplus.gov/ency/patientinstructions/000381.htm

Types of PPIs

Omeprazole (Prilosec), also available over-the-counter (without a prescription)
Esomeprazole (Nexium), also available over-the-counter (without a prescription)
Lansoprazole (Prevacid), also available over-the-counter (without a prescription)
Rabeprazole (AcipHex)
Pantoprazole (Protonix)
Dexlansoprazole (Dexilant)
Zegerid (omeprazole with sodium bicarbonate), also available over-the-counter (without a prescription)


35 posted on 08/14/2023 6:40:23 AM PDT by GOPJ (FoxNews Debate first time Trump ran: Democrat Chris Wallace with a blond bimbo. And this time?)
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To: goodnesswins

I read somewhere that low stomach acid can cause acid reflux. There’s a sphincter at the base of the esophagus that closes in response to the presence of stomach acid. But if the acid is weak, it gets only a weak signal to close and you wind up with acid getting by and causing burning. The solution was to drink a tablespoon of vinegar as counterintuitive as that sounds. I can’t remember where I read it, and I’ve never tried it, but I thought it was an interesting angle.


36 posted on 08/14/2023 7:10:35 AM PDT by Yardstick
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To: scouter

Unfortunately, famotidine didn’t work for me. Dexilant seems work best although several days a week nothing works. So it goes.


37 posted on 08/14/2023 7:34:08 AM PDT by thegagline (Sic semper tyrannis! Goldwater in 2024)
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To: bobcat62

That is a sure sign of early dementia.


38 posted on 08/14/2023 7:52:28 AM PDT by entropy12 (Career politicians like DeSantis build wealth. Trump sacrificed his wealth to serve people.)
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To: Drew68

Only 1 thing gives me heartburn, stomach pain and pain in bowel. It is coffee! Tea, cola, beer, no problem. I guess I am allergic to coffee.


39 posted on 08/14/2023 7:55:34 AM PDT by entropy12 (Career politicians like DeSantis build wealth. Trump sacrificed his wealth to serve people.)
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To: stylecouncilor

ping


40 posted on 08/14/2023 7:57:53 AM PDT by windcliff
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