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Lyme Disease Vaccine Could Be Coming Soon (2025?)
Axios ^ | April 25, 2023 | Tina Reed

Posted on 04/25/2023 4:31:04 PM PDT by nickcarraway

More than two decades after a promising vaccine for Lyme disease was pulled from the market, more tools to protect against the tick-borne illness —including a new shot — are on the horizon.

Why it matters: There's worldwide concern about how climate change is helping drive the proliferation of ticks and transforming Lyme disease from a regional summertime nuisance into a year-round health threat that can damage the nervous system and require several weeks of intravenous antibiotic therapy.

"Untreated, Lyme disease can be very serious," Leana Wen, an emergency physician and a professor at George Washington University, told Axios Today. "Some people develop debilitating symptoms that really impact their lives."

The big picture: Even though several Lyme disease vaccines are available for dogs, humans haven't had an option since LYMERix — made by the former SmithKline Beecham — was pulled from the market in 2002 due to low consumer demand tied to reports of arthritis and other adverse events and anti-vaccine sentiment.

"The FDA found insufficient evidence to support a causal relationship between the reported adverse effects and the vaccine and continued to permit use of the vaccine," researchers wrote in Epidemiology & Infection in 2007 examining what happened. "However, the public's perception of potential risks, heavily influenced by the negative press coverage and limited awareness of the benefits of the vaccine, decreased consumer demand for the vaccine."

That left the public without alternatives except for antibiotics like doxycycline after a tick bite, while drugmakers begged off new shots, fearing market risk, Nadine Bowden of the National Institute of Allergies and Infectious Diseases (NIAID) told Axios. "Is it worth the investment and worth the risk?" she said.

That could all change in the next couple of years. Earlier this month, Moderna announced two novel mRNA vaccine candidates against Lyme disease in its pipeline.

Another vaccine candidate, VLA15, from Pfizer and its partner Valneva is already in late-stage clinical trials, and enrolling trial participants, including children as young as five. The companies hit a snag in February when they had to toss the results of about half of their clinical trial participants due to problems in how the study was run by a third-party operator.

The companies nonetheless say they still could apply for Food and Drug Administration authorization as early as 2025.

What to watch: Researchers are exploring a number of other ideas to prevent Lyme disease, including a human monoclonal antibody designed to be used as pre-exposure prophylaxis (PrEP) for Lyme disease.

Researchers also are studying whether to inoculate mice in areas with high tick populations, in the hope of passing the resulting immunity on to the ticks themselves.

Other scientists are trying to perfect more sensitive tests that go beyond targeting the virus itself to biomarkers the body releases when Lyme disease is present.

Ten teams advanced to the second round of the LymeX Diagnostics Prize, sponsored in partnership between HHS and the Steven & Alexandra Cohen Foundation, to accelerate effective diagnostic tools toward FDA review. The winners are expected to be announced in December. The bottom line: For now, the best way to protect yourself is to use insect repellent, wear clothing that covers your arms and legs when in tick-infested areas and check for ticks when you get back.

But after years of relying on such preventive steps, an age of advanced drugs and vaccines could be nigh.

Thinking about getting a Lyme disease vaccine if it becomes available? Tell us more by filling out this form. (Some responses may be featured in future Axios newsletters and on Axios.com.)


TOPICS: Business/Economy; Health/Medicine; Science
KEYWORDS: disease; donate; donatedonaldtrump; donatetrump; lyme; lymedisease; tightwad; vaccines
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To: DesertRhino

Those experimental covid vaccine did nothing bad to me.


21 posted on 04/25/2023 5:40:25 PM PDT by entropy12 (Food is most popular anxiety drug, exercise is the least popular.)
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To: BipolarBob

I had my covid vax at age 80.
75 years later I will not need any vaccines.


22 posted on 04/25/2023 5:42:12 PM PDT by entropy12 (Food is most popular anxiety drug, exercise is the least popular.)
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To: nickcarraway

Nope. Credibility gone.


23 posted on 04/25/2023 5:44:46 PM PDT by blackdog ((Z28.310) We're all Women now.)
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To: Vaquero

I’m pretty sure I ran across a number of research papers indicating that Ivermectin treats/cures Lyme Disease. Wish I’d saved them, because I can’t find them now.


24 posted on 04/25/2023 5:44:47 PM PDT by Non-Compliant_Deplorable
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To: vivenne
Lyme was developed by the US Govt and I believe was intentionally let loose im Lyme, Connecticut to infect our citizens.

A few years ago, I would have said, that would be the view of a lunatic. Today, I would say, nothing would surprise me.

25 posted on 04/25/2023 5:56:33 PM PDT by Mark17 (Retired USAF air traffic controller. Father of USAF pilot. USAF aviation runs in the family )
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To: All

(mRNA)

Well gee.

What a surprise.....😬😬😬


26 posted on 04/25/2023 6:04:33 PM PDT by SaveFerris (Luke 17:28 ... as it was in the days of Lot; they did eat, they drank, they bought, they sold ......)
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To: nickcarraway

It’s really sad we have no choice but to respond with skepticism about a vaccine for a disease that often has permanent debilitative effects. I was case number 72 back in the mid 80s (I grew up roughly 50 miles from Lyme Connecticut) . Luckily my doctor was up on the symptoms of the disease and immediately prescribed me tetracycline . Another week untreated and I may very well have died or become permanently paralyzed. Im hopeful for this vaccine and yet...I still wouldn’t take it — especially when the treatment if caught early is pretty darned effective .Im (assuming of course the disease hasn’t mutated since I was diagnosed.)


27 posted on 04/25/2023 6:15:29 PM PDT by Free Louie
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To: nickcarraway
That left the public without alternatives except for antibiotics like doxycycline after a tick bite, while drugmakers begged off new shots, fearing market risk, Nadine Bowden of the National Institute of Allergies and Infectious Diseases (NIAID) told Axios. "Is it worth the investment and worth the risk?" she said.

They sure didn't have those reservations about the Covid so-called vax which is nowhere near the risk to people that Lyme is.

For the record, tick season is here and after we've been out on the property, we do a tick check every night. We also treat our outdoor clothes with Sawyer's permethrin spray and DEET to repel them. Two years ago, it was a really bad year and we treated the lawn with insecticide pellets which really helped.

This year, we are trying more natural controls with beneficial insects and nematodes, from a place called Nature' Good Guys. Arbico Organics also carries stuff like that but they are more expensive.

28 posted on 04/25/2023 6:32:21 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith….)
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To: entropy12

Oh, well that settles it if nothing bad happened to you.


29 posted on 04/25/2023 6:39:54 PM PDT by DesertRhino (Dogs are called man's best friend. Moslems hate dogs. Add it up..)
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To: Vaquero

lyme disease can be treated with ivermectin


30 posted on 04/25/2023 7:03:59 PM PDT by SisterK (it's controlled demolition)
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To: Mark17; vivenne

So that was the thinking of conspiracy theorist 15-20 years ago… then someone dug up ‘samples’ of deer ticks kept in some biology lab that dated back to the 1940s. Supposedly these samples were infected with Lymes way before it was first discovered in humans. Of course the conspiracy could also be the planting of the pre human infected tick samples.

I keep my tin foil hat on anyway as it’s harder and harder to trust those ‘in charge’

Ps. Lyme Connecticut is just a few miles from Plum Island across LI Sound. Plum is where the US Government does nasty stuff with diseases to weaponize them.


31 posted on 04/26/2023 4:43:14 AM PDT by Vaquero (Don't pick a fight with an old guy. If he is too old to fight, he'll just kill you. )
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To: DesertRhino

I understand it irritates paranoid people to hear 265+ million jabbed and anecdotes about adverse effects do not add up to one million (0.3% if it adds up to a million).


32 posted on 04/26/2023 10:44:52 AM PDT by entropy12 (Food is most popular anxiety drug, exercise is the least popular.)
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To: SisterK

Ivermectin is in wide use as de-wormer for horses as well.


33 posted on 04/26/2023 10:45:56 AM PDT by entropy12 (Food is most popular anxiety drug, exercise is the least popular.)
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To: entropy12

yes
and goats, sheep, cattle, dogs...
and it was first used on people for third world diseases


34 posted on 04/26/2023 1:05:41 PM PDT by SisterK (it's controlled demolition)
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To: nickcarraway

Spiced with spiked proteins.


35 posted on 04/27/2023 11:46:35 AM PDT by Old Yeller
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To: nickcarraway

I sure would be nice if they came up with something effective. Right now all you can do is use spray and check for ticks each day.


36 posted on 04/27/2023 11:55:09 AM PDT by 1Old Pro
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