Diabetes breakthrough: Gel-like sieve in blood vessels a new target for repairing damaged hearts (Glycocalyx repair helped in just three hours)

Medical Xpress / University of Bristol / Diabetologia ^ | Feb. 25, 2022 | Yan Qiu et al

[ConservativeMind]

Drugs that repair damage to a gel-like layer in the tiny blood vessels of the heart could present a much-needed treatment for heart failure in people with diabetes, according to research.

The gel-like layer—called the glycocalyx—lines the inside of blood vessels and acts like a sieve to regulate how nutrients move from the blood to the heart and other tissues in the body.

Professor Simon Satchell looked at mice with type 1 and type 2 diabetes and discovered that the glycocalyx in the small blood vessels of the heart became damaged.

They found that this damage was associated with increased fluid movement into the walls of the heart, leading to swelling and increased stiffness of the heart muscle. This prevented the heart from properly relaxing between beats, meaning the heart could not pump blood around the body effectively.

To see if repairing the glycocalyx improved the function of the heart, diabetic mice were given a substance known to restore the glycocalyx, called angiopoietin 1. At three hours after treatment the researchers found that glycocalyx coverage and thickness had increased in the blood vessels. When they looked at the ultrasound scans of the heart, their ability to relax between beats also improved.

The team plan to identify key changes in the glycocalyx of diabetic patients. Further research is needed to determine whether protecting the glycocalyx from breaking down can lessen heart problems seen in these people.

These findings have far-reaching implications in protecting against other types of organ failure, since the glycocalyx is present in all blood vessels.

Professor James Leiper said that "this is the first evidence that damage to the glycocalyx in the small vessels of the heart might be involved in diabetic heart failure."

[ConservativeMind]

There is actually a supplement that specifically addresses patching up the glycocalyx, called “Arterosil-HP.” I found it two years ago from a study that called out its use of a seaweed component as particularly helpful (I may have posted it on Free Republic).

The substance used in this study was “angiopoietin 1.”

[ConservativeMind]

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Now keeping a new list for conditions expected to concern at least 1% of the population. Ask to be on the “Common Issues” list.

Please email or private message me if you want on or off of a list and of which list you desire.

[nopardons]

BTTT

[thinden]

bttt

[ConservativeMind]

Rhamnan sulfate may be that seaweed component.

[spirited irish]

Thank-you!

[Guenevere]

G

[LS]

Thanks for posting these. I find them very helpful, and no other site bothers with them.

[Pete from Shawnee Mission]

C.M., Thank you!

Link to additional information on this subject

https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/glycocalyx

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Not just vascular repair but also pulmonary blood vessels.

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Membranes in Pulmonary Vascular Disease

Wells B. LaRivière, Eric P. Schmidt, in Current Topics in Membranes, 2018

“Emerging evidence indicates that processes of glycocalyx reconstitution are necessary for endothelial repair and, as such, are promising therapeutic targets to accelerate lung injury recovery. This review discusses what has been learned about the homeostatic and pathophysiologic role of the pulmonary endothelial glycocalyx during lung health and injury, with the goal to identify promising new areas for future mechanistic investigation.”

and:

Endothelium

M.S. Goligorsky, K. Hirschi, in Advances in Pharmacology, 2016
8 Perturbations of Endothelial Surface Glycocalyx

(Arterosil-HP is a bit pricey!)

[Pete from Shawnee Mission]

CM; The post sent me on a bit of a chase this morning!

Marine Medicinal Foods

(HSV-1 = herpes simplex.)

Se-Kwon Kim, ... Dai-Hung Ngo, in Advances in Food and Nutrition Research, 2011

” Subsequently, a polysaccharide from M. nitidum, rhamnan sulfate, was found to be effective against HSV-2 via blockade of virus adsorption and penetration steps onto host cell surface (Lee et al., 2010). Thus, it was indicated that some sulfated polysaccharides from green macroalgae not only inhibited the early stages of HSV replication, such as virus binding to and penetration into host cells, but also interfered with late steps of virus replication. Likewise, sulfated polysaccharide fraction isolated from the hot water extract of the green alga Caulerpa racemosa was regarded as a selective inhibitor of reference strains and TK− acyclovir-resistant strains of HSV-1 and HSV-2 in Vero cells, with EC50 values in the range of 2.2–4.2 μg/ml (Ghosh et al., 2004).”

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Time to start adding Nori to your diet?

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3.2 “Aonori” or green laver (Monostroma spp. and Enteromorpha spp.)

These two green seaweed genera are cultivated in Japan. Monostroma latissimum occurs naturally in the bays and gulfs of southern areas of Japan. It is a flat, leafy plant and only one cell thick. It contains 20% protein on average and has a useful vitamin and mineral content. The seaweed is washed well postharvest. It is then either processed into sheets and dried, as described for Porphyra, or dried and then boiled with sugar, soy sauce, and other ingredients to make “nori-jam.”

Nori;

Perhaps good for the endothelium, but lots of sodium so maybe not so much for blood pressure?

[jacquej]

Thank you for these posts, CM. I appreciate them. I would like to be on both lists. I may not post comments, but faithfully read them, and tuck the information away.

It is more helpful than you know. Helps to make me a bit wiser, which is a good thing.

[ConservativeMind]

I am glad to post them.

I've been reading study write ups for a long time, but seldom posted them, instead, keeping them on my phone or laptop to provide references to people, one at a time. In hearing about the health conditions of so many here on Free Republic, and with the urging my wife, friends, and family have given me to get a website going to offer such work, I compromised and have wanted to see if I could maintain the effort, here.

Determining which studies are “actionable,” digging up additional insights not given in the write up or study it's based upon, trimming it down to 300 words or less while maintaining readability, etc., does take time. Additionally, if you don't get the write up read or accessed within ten days, it's deleted from the inline history in these study write up engines, so you don't know they exist any longer without an explicit search and you can't do it by “day.” Medical Xpress even prevents access based on how many requests you've made in a certain number of seconds from your IP address (which may be a VPN used by others). In sum, there's hassle involved.

Thank you for your encouragement and I likewise want to encourage you with your worthy efforts. You are an encouragement to us, all.

[grey_whiskers]

Thanks Conservative mind!
*PING* to little jeremiah!

[DannyTN]

The Glycocalyx: Gatekeeper to Good Health?

• 3 major ways your glycocalyx keeps you healthy
• Why a high-carb diet damages the glycocalyx
• How to eat for your glycocalyx

Certain supplements may also help maintain a healthy glycocalyx. These include:

• Hyaluronic acid [42]
• N-acetyl cysteine (NAC) [43]
• Chondroitin sulfate [44]
• Nitric oxide boosters [45]
• Activated protein C [46]
• Hydrocortisone [47]
• Progesterone [48]

[LS]

Yours are the only items I ever see in all this.

It’s too bad the China Virus so disgraced medicine and medical professionals, because I think many are doing good work and genuinely helping people. But now we have to distrust them all.