Posted on 10/07/2021 9:35:40 AM PDT by Red Badger
Researchers from the University of Toledo have discovered a prospective new treatment for rheumatoid arthritis. The vaccine-based treatment strategy proved successful in preliminary animal studies and the researchers are looking to conduct more clinical trials in the future.
The research hinges around a protein called 14-3-3 zeta. Ritu Chakravarti, lead author on the new study, has been studying 14-3-3 zeta for several years due to its suspected role in a number of autoimmune conditions.
The initial hypothesis was this protein played a significant role in the onset of rheumatoid arthritis. If it was triggering the disease then knocking out the gene in arthritis mouse models should prevent the condition arising in the first place.
But to the researchers surprise, the exact opposite happened. When the mice were deprived of 14-3-3 zeta they demonstrated accelerated disease progression. More specifically, the researchers noted arthritis seemed to be induced in the animals alongside the loss of anti-14-3-3 zeta antibodies
So the research team then developed a novel protein-based vaccine to stimulate production of anti-14-3-3 zeta antibodies and it successfully prevented the development of disease in several animal models.
“Much to our happy surprise, the rheumatoid arthritis totally disappeared in animals that received a vaccine," says Chakravarti. "Sometimes there is no better way than serendipity. We happened to hit a wrong result, but it turned out to be the best result. Those kinds of scientific discoveries are very important in this field."
It is very early days for the research with safety and toxicity studies yet to be conducted. This means it is not clear whether this kind of prophylactic vaccine therapy is safe in humans, but Chakravarti is optimistic. She says these findings point to an entirely new pathway for future research into novel arthritis treatments.
"We have not made any really big discoveries toward treating or preventing rheumatoid arthritis in many years," says Chakravarti. "Our approach is completely different. This is a vaccine-based strategy based on a novel target that we hope can treat or prevent rheumatoid arthritis. The potential here is huge."
The new study was published in PNAS.
Fantastic if it pans out.
Thanks for the post.
Does it require booster shots? And can I spend Christmas with my family? Or is it an actual vaccine? You know: a real one.
Sadly, it’s likely ‘just now discovered’ because people are refusing to get the Covid fake vaccine and so they dragged out something with more appeal. :(
depriving the mice of 14-3-3 increased the arthritis. So the team stimulated antibodies against 14-3-3 and that cured them?
it seems like both are going in the same direction. They should have increased the 14-3-3 zeta not antibodies against it?
Good ,so in 10 t0 15 years they might have a real Vaccine for that.
Yeah. Sure. All of medical research revolves around a covid conspiracy.
The idiocy around here nowadays is epic.
Its a little confusing but the original article explains it like this. When they knocked out the gene for the protein first it triggered inflammatory arthritis and also reduced the corresponding antibodies for the protein.
When they next tried to reverse the arthritis they had induced with the vaccine to generate the missing antibodies it didn’t reverse the arthritis.
When they vaccinated the mice first before knocking out the gene that made the protein it did prevent arthritis. The lesson is they must use the vaccine preemptively before symptoms develop in the joints for it to prevent the onset of arthritis. It doesn’t cure arthritis, it just prevents it from occurring if the protein production is disrupted.
“So the research team then developed a novel protein-based vaccine to stimulate production of anti-14-3-3 zeta antibodies and it successfully prevented the development of disease in several animal models.”
Sounds like an mRNA vaccine, like the one being used for covid.
“immune suppression and extracellular remodeling”
sounds like fun
Sounds like something that happens in prisons...................
Boron is used with great success for arthritis by many people.
https://nexusnewsfeed.com/article/consciousness/the-borax-conspiracy-how-the-arthritis-cure-has-been-stopped
It’s called rheuma-vectin.
Pain reliever companies will try to squash this quick.
I'm not about to try any new vaccine, as all the vaccine makers have been lying.
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