Team discovers surprise contributor to multiple sclerosis

medicalxpress.com ^ | October 7, 2019 | University of Virginia

[BenLurkin]

Cells that scientists have largely ignored when studying multiple sclerosis are actually key contributors to MS development, new research from the University of Virginia School of Medicine shows. The discovery suggests new avenues for devising treatments and is a vital step toward finding a cure.

Cells that scientists have largely ignored when studying multiple sclerosis are actually key contributors to MS development, new research from the University of Virginia School of Medicine shows. The discovery suggests new avenues for devising treatments and is a vital step toward finding a cure.

In MS, the body's immune system begins to attack the myelin, leading to a progressively disabling neurological condition that affects more than 2 million people worldwide. (MS is the most common neurological condition among the young, and is often diagnosed between ages 20 and 50.)

It has been thought that these progenitors do not efficiently give rise to myelin-producing cells in people with MS. Yet, UVA's Alban Gaultier, Ph.D., and his team made the surprising discovery that they are also actively participating in the immune system's harmful attacks on myelin.

[nagant]

>>Here is a potential cure:
Metformin ‘can reverse nerve damage caused by MS in rats in three months
https://www.dailymail.co.uk/health/article-7536823/Type-2-diabetes-drug-offer-hope-multiple-sclerosis-study-rats.html<<

Metformin is a drug which removes glucose from the blood, and places it into the urine. If Metformin is successful at reversing multiple sclerosis then how is it possible for fat to, in any way, be a cause of multiple sclerosis?

[meatloaf]

Gut dysbiosis, diet, environment, etc. probably provide multiple factors that instigate auto immune diseases. Science works by pigeonholing information. Chances are all autoimmune disease have a common source.

[Rockingham]

A substantial accumulation of epidemiological and other evidence suggests that varicella zoster, the chicken pox and shingles virus, is responsible for MS. My layman’s guess is that this is correct and that the case will be proved within five years.

[think4yrsf]

I hear the photo of the researches was taken by a Freeper

[nagant]

I believe you are correct. Disbiosis-created leaky gut doesn’t use the vagus nerve exclusively to spread autoimmune disease, it also uses the bloodstream.

However, there is one glaring exception, mitochondrial autoimmune disease. Mitochondria are the energy engines of cells. Cell mitochondria are evolved bacteria. Mitochondria have their own DNA. The DNA are arranged in a “D-loop”. Mitochondrial electron chains have four work complexes which normally coordinate like well-oiled little machines. However, ingestion of aspartate and glutamate causes mitochondrial complexes to go out of phase with each other. Besides overall shutdown of the electron chain, the chain starts throwing off randomly mutated proteins. The proteins displace genes in the d-loop.

Some of the d-loop proteins end up embedded in cell walls. The immune system recognizes affected cells as a bacterial infection, and starts killing cells. Most schizophrinia and autism have their roots in mitochondrial autoimmunity. Dr. Walace, an Australian doctor, is tops in this research field. You can search Youtube for breakdowns.