Posted on 08/10/2014 12:46:23 AM PDT by Smokin' Joe
I have spent a little time compiling links to threads about the Ebola outbreak in the interest of having all the links in one thread for future reference.
Please add links to new threads and articles of interest as the situation develops.
Thank You all for you participation.
https://microbewiki.kenyon.edu/index.php/Infection_Mechanism_of_Genus_Ebolavirus
@end of article
.....Meanwhile, the immune system is going haywire (Fig 21). Interferons are not being made because VP35 interferes with nearly every step in the process [2]. White blood cells are trapped inside the circulatory system because sGP limits their movement [49]. Macrophages and monocytes are releasing a cocktail of proinflammatory cytokines that destroy the vascular endothelium, but also activate the coagulation cascade. This puts your body in a paradoxical state in which you can die of hypovolemic shock from massive hemorrhage, or from catastrophic thrombosis, the formation of blood clots around the body [17].
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Cytokine storms
A JOLLA, CA—February 27, 2014—Scientists at The Scripps Research Institute (TSRI) have mapped key elements of a severe immune overreaction—a “cytokine storm”—that can both sicken and kill patients who are infected with certain strains of flu virus....
http://www.scripps.edu/news/press/2014/20140227oldstonerosen.html
as of yesterday, the sept 6th report showed 4293 cases and 2296 deaths.
checking just now, they've changed the date from sep 6th to sep 7th, the number of cases to 4366 and the total deaths to 2218
looks like 78 people came back to life!
well, here's the latest numbers and charts:
For that matter, if Ebola ever infects a promiscuous man (or woman) in the US, it will spread through the community within a month.
But, the thing to note is that far more casual contact than sexual relations will spread the disease. You don't even need to get kissed (although all that will do the job).
A black market for an Ebola treatment derived from the blood of survivors is emerging in the West African countries experiencing the worst outbreak of the virus on record, the World Health Organization said.
The United Nations health agency will work with governments to stamp out the illicit trade in convalescent serum,
WHO Director-General Margaret Chan told reporters today in Geneva, where the organization is based.
There is a danger that such serums could contain other infections and wouldn’t be administered properly, Chan said.
The WHO is encouraging the use of properly obtained serum to treat current patients and said last week it should be a priority ... (continues)
“Filoviruses”: a real pandemic threat? EMBO Molecular Medicine 3/26/2009High numbers of filovirus particles can be found in sweat glands and the human skin (Zaki et al, 1999), suggesting that transmission may occur through direct contact and that nursing patients and preparing bodies for burial without practicing the appropriate barrier precautions, represent an important factor contributing to the spread of the infection. However, it remains unclear how the virus enters the body upon direct contact. It has been shown that administration of filoviruses into the mouth, nose, or conjunctiva of non‐human primates resulted in infection (Jaax et al, 1996; Schou & Hansen, 2000). Therefore, it is conceivable that human infections occur through indirect contact of, for example, contaminated fingers with oral mucosa or conjunctiva. The REBOV outbreak and experimental infections carried out with ZEBOV have raised concerns that EBOV may be naturally transmitted by aerosol (Jahrling et al, 1990; Johnson et al, 1995). There is also circumstantial evidence that during the EBOV outbreak in DRC in 1995, some patients became infected through aerosol transmission (Roels et al, 1999). However, although aerosol transmission cannot be completely ruled out, the primary mode of transmission is through direct or indirect contact with an infected body and thus transmission of filoviruses is an inefficient process.
I can't find the article at the moment but dendritic cells are one of the first attacked by Ebola. Details on the location of dendritic cells:
Dendritic cells are found in tissue that has contact with the outside environment such as the over the skin (present as Langerhans cells) and in the linings of the nose, lungs, stomach and intestines. Immature forms are also found in the blood. Once activated, dendritic cells move to the lymph tissue to interact with to interact with T cells and B cells and help shape the adaptive immune response. During development, they develop branched projections called “dendrites”, which is why the cells are so named.
Intracellular Events and Cell Fate in Filovirus Infection (NIH Aug 2011)Filoviruses have a broad cell tropism in susceptible host species. Among the target cells supporting viral replication are monocytes, macrophages, dendritic cells (DCs), hepatocytes, adrenal cortical cells, fibroblasts and endothelial cells [43–57].
The earliest events during infection are likely to center around cells of the mononuclear phagocyte system, including monocytes, macrophages, and DCs. These cells not only orchestrate innate and adaptive immune responses [58,59], but also serve as early targets of viral infection [47–49,55,56, 60–66]. It is thought that the early infection of these cells is responsible for the rapid and widespread dissemination of the virus throughout an infected host [67].
I wasn’t looking for that at all. It hit me like a ton of bricks. I saw pneumoviridae and went, “WHAT???”
One would think your idea had been performed a long time ago but like every other group of humans, scientists fall all too easily into groupthink (see the history of gastric ulcers for an example.) Perhaps it struck me so hard because I’m not surrounded by virology all day and of course I could be completely wrong, but sometimes it takes an outsider to put two and two together.
Bless you for your reply. I realized only later that I needed to use diiferent search terms ( and a virology dictionary ).
That ZEbola is one devious as well as lethal rascal.
More grateful thanks. You’ve given me enough to put me on another track.
Agreed. Given that it attacks dendritic cells immediately I am more skeptical than ever regarding the “hard to catch” meme. The dendritic infection also explains the Ebola rash that is rarely mentioned as an early symptom.
Thanks again.
Anything for a fellow Chesterton fan.
You are reading way too much into the phrase "is approximated only by" and mentally substituting "came from" for which there is no evidence.
Notice the "early symptoms" of Ebola. Cough.
Practically all systemic disease involves tussis at some point. Not surprising since the respiratory system is so sensitive and fragile. Not indicative in itself of bio-engineering efforts.
If someone engineered this as an airborne virus they did a damn poor job of it!
If I implied that I think the proteins are identical or the EBOV “came from” the pneumovirus, that was not intended. I said approximated because that’s what I meant, approximated.
That this type of protein is found ONLY in EBOV and pneumoviridae may mean nothing. Then again it may mean a lot. It has me thinking.
I don’t know why you’re going on about bioengineering. I have never said, suggested or thought that this is bioengineered. It’s a wild virus, plain and simple.
It’s also true that because both EBOV and pneumoviridae are both negative sense RNA viruses, recombination and other forms of genetic sharing would be very easy between them. Who knows, perhaps one picked up the gene from the other. That would require a lot of study to determine.
I take it you haven’t been following the WHO/CDC/etc as they insist that there is no respiratory effect from Ebola. As we know, many non-WHO sources are insisting that cough is in fact an early symptom and given that dendritic cells are one of EBOV’s first and favored cells, it’s perfectly reasonable to conclude that infectious droplets expelled via cough are a transmission vector. Even the WHO quietly admitted it when they mandated their community workers to keep a minimum distance of 3 feet between them and everyone else. But we still have plenty of authorities insisting that the only way one can contract Ebola is by handling vomit or blood barehanded.
Anyway, I hope others read exactly what I write and don’t assume I mean anything other than the words I use. I am careful to say precisely what I mean.
“Not indicative in itself of bio-engineering efforts. “
Please indicate which portion of her post stated such a thing.
Thanks in advance!
My Chesterton tag line is so apropos that I don’t envision the need for a change in this millenium.
;>)
This source provided me with a concise and relatively understandable ( as lay man) source of info.
The most surprising thing about ZEbola is the speed with which it turns the immune systems first responders to its advantage, co-opting them as it were.
From the cited link:
https://microbewiki.kenyon.edu/index.php/Infection_Mechanism_of_Genus_Ebolavirus
@end of article
.....Meanwhile, the immune system is going haywire (Fig 21). Interferons are not being made because VP35 interferes with nearly every step in the process [2]. White blood cells are trapped inside the circulatory system because sGP limits their movement [49]. Macrophages and monocytes are releasing a cocktail of proinflammatory cytokines that destroy the vascular endothelium, but also activate the coagulation cascade. This puts your body in a paradoxical state in which you can die of hypovolemic shock from massive hemorrhage, or from catastrophic thrombosis, the formation of blood clots around the body [17]
That certainly recalls the relatively recently postulated role of cytokine storms in the Spanish Flu’s high fatality rate among the young and healthy.
http://www.mcclatchydc.com/2014/09/12/239696_obama-to-head-to-cdc-for-ebola.html?&rh=1
“Obama to head to CDC for Ebola briefing”
https://asunews.asu.edu/20140911-ebola-transmission-rate-research
“Ebola paper demonstrates disease transmission rate”
“Ebola surging beyond control, WHO’s Margaret Chan warns”
http://www.cnn.com/2014/09/12/health/ebola-airborne/
“Ebola in the air? A nightmare that could happen”
Let’s hope not.
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